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Review Article  |   Volume 2, Issue 2

Hepatic Cancer Stem Cells and Signaling Pathways

Mohammad Khalid Zakaria, Ashraf Ali, Kaneez Fatima, Mohd Suhail, Shilu Mathew, Saleh Alkarim, Esam Azhar and Ishtiaq Qadri
Abstract

Loss of hepatocytes due to infection, inflammation or partial hepectomy simulates a response which helps in the liver restoration. This maintains homeostasis and keeps a check on the usual wear and tear in the liver. Cancer stem cells (CSCs) were demonstrated to be associated with myeloid leukemia. However, with recent advancements in the approaches and techniques, CSCs are also present within a wide variety of solid tumors and malignancies of epithelial origin.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/2/2/1017

Research Article  |   Volume 2, Issue 2

The Shortage of Essential Cancer Drugs and Generics in the United States of America. Global Brain Storming Directions for the World.

Ahmed Elzawawy
Abstract

The shortage of the older essential cancer drugs that are off patent, mostly generics and injectable, has its threatening impact on health of cancer patients, clinical trials and the burden of costs spending on the health system in the United Sates. The problem is multifactorial and mostly economical and due to lack of incentives for production.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/2/2/1016

Research Article  |   Volume 2, Issue 2

Web-Based Quality of Life Questionnaire Followed by Paper-Based Questionnaire for the Non-Responders: Daily Practice in Patients with Prostate Cancer

Tillier CN, van Stam MA, de Blok W, van Muilekom HVM, Bloos-van der Hulst J and van der Poel HG
Abstract

Patient-related outcome measures (PROMS) play an increasingly important role in the planning and evaluation of medical care. A high response rate is crucial to get a good view of the patient population. Quality of life questionnaires in oncology are important in order to evaluate the impact of the disease or the treatment of cancer patients and guide treatment decisions.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/2/2/1015

Original Article  |   Volume 2, Issue 2

Nitric Oxide Attenuates Hypoxia-Induced 5-FU Resistance of Oral Squamous Cell Carcinoma Cells

Eri Sasabe, Ayumi Tomomura, Mayuko Hamada, Naoya Kitamura, Tomohiro Yamada and Tetsuya Yamamoto
Abstract

Hypoxic environments in tumors induce expression of hypoxiainducible factor (HIF). HIF contributes to the development of the malignant progression through the induction of various target genes. We previously reported that treatment with chemotherapeutic drugs and γ-rays enhances expression and nuclear translocation of HIF-1α under normoxic conditions; susceptibility of oral squamous cell carcinoma (OSCC) cells to the drugs and γ-rays is negatively correlated with expression of HIF-1α protein.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/2/2/1014