Targeting of Myeloid Derived Suppressor Cells Using Anti-inflammatory and Pro-inflammatory Agents
Parvin Forghani and Edmund K Waller
Article Type: Review Article | First Published: October 03, 2015
Myeloid-derived suppressor cells (MDSC) have been considered to be key mediators of immuno-suppression in cancer. The numbers of MDSCs increased in the blood and in the tumor microenvironment during inflammation. Due to the strong correlation between inflammation and cancer that results in tumor progression through MDSCs-associated immune-suppression, it is posited that modulating MDSCs using anti-inflammatory drugs will enhance the activity of immunotherapy and antitumor immunity....
Systematic Review and Meta-Analysis to Determine the Optimum Staging modality for Primary Breast Cancer
Berney M, Manning A, Carter M, Sacchini V, Kell M R. Barry M
Article Type: Original Article | First Published: September 24, 2015
Staging of primary breast cancer can radically alter the management if stage IV disease is accurately detected. A systematic review and meta-analysis were performed to determine whether conventional CT TAP or PET-CT provides the optimum staging modality. A meta-analysis involving 158 patients with primary breast cancer showed that PET-CT was more sensitive than CT-TAP for detection of metastatic disease (OR 3.28, 95% CI 2.37 - 4.53, p < 0.0001). A systematic review of 1780 patients undergoing PE...
Common Polymorphisms in the USF1 Gene and Cancer Susceptibility: A Meta-Analysis
Meng Zhang, Jian Bai1, Junjie Huang, Yukun Ge, Hu Xiong, Wei Lu, Jizhou Shi, Lu Fang, Song Wu and Zhiming Cai
Article Type: Original Article | First Published: September 21, 2015
Upstream transcription factor 1(USF1) has been identified to be implicated in the development of many cancer categories. In view of recent studies, several polymorphisms in USF1 gene appeared to exert diverse influence on cancer susceptibility. However, the association between USF1 polymorphisms and cancer susceptibility remains inconclusive due to the finite relevant published discoveries. Therefore, we conducted a meta-analysis by pooling all available published data on the susceptibility of U...
The Influence of Melatonin on Immune System and Cancer
Anna Gry Vinther and Mogens H. Claesson
Article Type: Review Article | First Published: September 19, 2015
Melatonin has been shown to play a fundamental part in neuro immune modulation. Besides regulating the circadian rhythm it works as a natural antioxidant with immune stimulatory and anti-cancer properties. Melatonin is a regulator of hemopoiesis and modifies various cells and cytokines of the immune system. Melatonin elicits oncostatic properties in a variety of different tumor cells....
A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation
Peter Oladimeji, Yuzuru Kubohara, Haruhisa Kikuchi, Yoshiteru Oshima, Courtney Rusch, Rebekah Skerl, Maria Diakonova
Article Type: Original Article | First Published: September 17, 2015
Differentiation-inducing factors 1-3 (DIFs 1-3), chlorinated alkylphenones identified in the cellular slime mold Dictyostelium discoideum, are considered anti-tumor agents because they inhibit proliferation of a variety of mammalian tumor cells in vitro. Although the anti-proliferative effects of DIF-1 and DIF-3 are well-documented, the precise molecular mechanisms underlying the actions of DIFs have not been fully elucidated. In this study, we examined the effects of DIFs and their derivatives ...