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Case Report Open Access

Long-Term Survival and Quality of Life Outcomes with Multiple Gamma Knife Radiosurgeries for Metastatic Breast Cancer to the Brain: Case Report and Review of Literature

Andrew T Roehrig, Ethan Ferrel, Robert K Fairbanks, Wayne T Lamoreaux, Alexander R MacKay, Jason A Call, John J Demakas, Aaron Wagner, Barton S Cooke, Benjamin C. Ling, Jonathan D. Carlson and Christopher M Lee
Int J Cancer Clin Res Volume 2, Issue 5

Abstract: Metastatic disease to the brain from breast cancer can be treated with multiple modalities. Determining effective therapies for select patients with brain metastases is critical to maximizing survival and quality of life. Stereotactic radiosurgery (SRS) can be an effective option for select patients with brain metastases, and is highly targeted with rapid fall-off of radiation dose outside the treatment zone. The following case illustrates the potential use of multiple Gamma Knife Radiosurgery (GKRS) sessions for a patient with metastatic breast cancer. In this specific case, repeat treatments led to prolonged survival and improved quality of life for a patient with multiple intracranial tumors from metastatic breast cancer.

PDF   | Full Text   DOI: 10.23937/2378-3419/2/5/1036

Original Article Open Access

Fascin is Expressed in Basal-Liketype Triple Negative Breast Cancer Associated with High Malignant Potential in Japanese Women

Hiromichi Tsuchiya, Akiko Sasaki, Yuko Tsunoda, Masafumi Takimoto, Terumasa Sawada, Seigo Nakamura, kentaro Iijima and Katsuji Oguchi
Int J Cancer Clin Res Volume 2, Issue 5

Abstract: No molecular targeted drug has been developed for poor-prognostic triple-negative breast cancer (TNBC) because it has no hormone or human epidermal growth factor receptor 2 (HER2) sensitivity. In addition, TNBC has recently been sub classified into 6 types. In this study, we analyzed the expression of Fascin, an actin-binding protein associated with breast cancer, in 301 invasive breast cancer samples. Of these, 32 were identified as TNBC and were classified into the basal-like type and other non-basal-like subtypes. We also investigated the association of Fascin expression with clinic pathological factors.

PDF   | Full Text   DOI: 10.23937/2378-3419/2/5/1035

Case Report Open Access

Palliative Management of Malignant Bowel Obstruction with Carcinomatosis

Kirti Joseph, Jaclyn Schneider and Amy A Case
Int J Cancer Clin Res Volume 2, Issue 5

Abstract: Mr. H was a 73 year old male with a past medical history of lumbar spinal degenerative disease, pyloric stenosis repair as a child and a Hartmann procedure for a perforated diverticulitis at age 43, with colostomy reversal shortly after. In August of 2014 he was diagnosed with stage 4 colon cancer, with extensive metastases to the lung including large masses that invaded into the airways as well as a right middle and upper lobe mass compressing the superior vena cava. He underwent and assisted laparoscopic right hemicolectomy of the ascending colon with anastomosis, and no ostomy due to large bowel obstruction, which was his presenting symptom at the time of diagnosis in August, 2014.

PDF   | Full Text   DOI: 10.23937/2378-3419/2/5/1034

Short Communication Open Access

C4.4A and Aldehyde Dehydrogenase 1 (ALDH1) May Contribute to breast Cancer not Mediated Through epithelial-Mesenchymal Transition

Natsuko Inoue, Takahiro Watanabe, Seiichi Hirota, Masahisa Ohtsuka, Hirofumi Yamamoto, Koji Morimoto, Toyomasa Katagiri and Yasuo Miyoshi
Int J Cancer Clin Res Volume 2, Issue 5

Abstract: C4.4A, a glycosylphosphatidyl-inositol-anchored membrane protein, plays an important role in epithelial-mesenchymal transition (EMT) affecting progression of colorectal cancer, while aldehyde dehydrogenase 1 (ALDH1) has been identified as a stem cell marker for breast cancer. Since cancer stem cells link to EMT phenotype, both molecules seem to be important for breast cancer progression mediated via EMT. In this study, associations between expressions of C4.4A or ALDH1 and vimentin, a mesenchymal marker, were immunohistochemically analyzed in 91breast cancer patients. Findings showed that 49 cancers (53.8%) were positive for C4.4A, 14 (15.4%) for ALDH1 and 12 (13.2%) for vimentin.

PDF   | Full Text   DOI: 10.23937/2378-3419/2/5/1033

Original Article Open Access

Feasibility and Efficacy of Definitive Hypofractionated High-Dose Radiotherapy for Cutaneous Angiosarcoma of the Scalp

Emiko Shimoda, Kazuya Inoue, Nobuhide Wakai, Yoko Morimoto, Isao Asakawa, Nobumasa Fujitani, Tadashi Yoshimine, Tetsuro Tamamoto, Maiko Takeda, Kohei Ogawa, Hideo Asada and Masatoshi Hasegawa
Int J Cancer Clin Res Volume 2, Issue 5

Abstract: Cutaneous angiosarcoma is a rare but highly aggressive vascular tumor resistant to all treatment modalities available. The aim of this study was to analyze the treatment outcomes of patients who received definitive hypofractionated high-dose radiotherapy (RT) for angiosarcoma of the scalp. Between April 2008 and December 2014, 11 patients with histologically proven cutaneous angiosarcoma of the scalp visited our Department of Radiation Oncology, because dermatologists suggested that there was no indication for surgery in those cases. One patient rejected all radical treatments and the other 10 patients were treated by RT with curative intent along with chemotherapy or immunotherapy.

PDF   | Full Text   DOI: 10.23937/2378-3419/2/5/1032

Research Article Open Access

Cervical Cytology Screening - Is the Change of Policy Risk Free?

Emily H. Hertzberg, Nurit Ariel, Dalia Kaplan, Michal Markovitz and Zeev Blumenfeld
Int J Cancer Clin Res Volume 2, Issue 5

Abstract: With the change in the cervical cancer screening guidelines, women younger than 21 will not be routinely screened and the screening interval is extended to three years. In spite of the well-received newly recommended guidelines on cervical cancer screening, how many patients will be excluded by the guidelines that may have otherwise benefited from the screening?. It is important to look at the trends in the screened population in order to answer this question. Our aim was to determine the effectiveness of the previous policy on cervical cancer screening in terms of incidence of cervical cancer and rates of dysplasia in the population of a tertiary hospital gynecology outpatient clinic.

PDF   | Full Text   DOI: 10.23937/2378-3419/2/5/1031

Volume 2
Issue 5