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Open Access DOI:10.23937/2378-3419/3/1/1044
Esther Dubrovsky, Farayan Jalalabi, Aysegul Sahin and Dalliah M Black
Article Type: Case Report | First Published: February 10, 2016
Prophylactic skin-sparing mastectomy (SSM) and nipple sparing mastectomy (NSM) have become suitable options for breast cancer prevention in appropriate patients with hereditary risk of breast cancer. Prophylactic total mastectomy (TM) provides approximately 90% to 95%- risk reduction in patients with BRCA1 and BRCA 2 mutations. Initially, bilateral TM was recommended because of the concern for an increased breast cancer risk from remaining residual breast tissue....
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Open Access DOI:10.23937/2378-3419/3/1/1045
Xiao Huang, Kazunori Kanehira, Fadi Habib and Bo Xu
Article Type: Case Report | First Published: February 19, 2016
Metastatic carcinoma to a lymph node with high grade lymphoma is very rare, particularly when high grade lymphoma is the first time diagnosis. Here we report a case where metastatic pancreatic ductal adenocarcinoma was found in a retroperitoneal lymph node with diffuse large B cell lymphoma (DLBCL). Histologically, the metastatic adenocarcinoma is located mainly in the subcapsular region....
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Open Access DOI:10.23937/2378-3419/3/1/1043
Developing Pathway Collection for Personalized Anti-cancer Therapy
Luminita Castillos and Anton Yuryev
Article Type: Research Article | First Published: February 01, 2016
We describe methodology for developing personalized anti-cancer drug therapy using pathway analysis. We successfully applied this methodology to treat several cancer patients that were terminally diagnosed by standard of care criteria at the hospital. Our approach consists of profiling patient tumor using gene expression microarray and calculating pathways responsible for the differential expression between tumor and normal control tissue....
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Open Access DOI:10.23937/2378-3419/3/1/1042
Breast Cancer in Surgical Site: Unusual Presentation of an Ectopic Milk Line Malignancy
Zsolt Varga, Miklos Torok, Eva Sebo, Judit Toth and Dezso Toth
Article Type: Case Report | First Published: January 30, 2016
A 56-year old woman with history of laparoscopic cholecystectomy was referred to outpatient clinic 3 years after the operation with a non-healing reddish lump in the surgical scar. The lesion was situated at the site of the right subcostal port, in the medioclavicular line, below the ribcage. Local excision was performed and histological evaluation revealed poorly differentiated adenocarcinoma, which was thought to be metastatic. After multiple recurrences, appearance of an axillary lymph node m...
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Open Access DOI:10.23937/2378-3419/3/1/1041
Shinichi Sekine, Takuya Nagata, Tomoyuki Okumura, Shunsuke Kawai, Katsuhisa Hirano, Takeshi Miwa, Makoto Moriyama, Hirofumi Kojima, Isaya Hashimoto, Kazuto Shibuya, Shozo Hojo, Isaku Yoshioka, Koshi Matsui, Shigeaki Sawada and Kazuhiro Tsukada
Article Type: Original Research | First Published: January 30, 2016
Pancreaticoduodenectomy (PD) is a highly invasive surgery. Therefore, assessment of pre-operative nutritional status may contribute to the postoperative course. Patients (n = 116) who had undergone PD were included in this study. We evaluated the usefulness of the body mass index (BMI), prognostic nutrition index (PNI), and controlling nutritional status score (CONUT) for evaluating post-operative complication risk by examining the relationship between pre-operative nutritional status and the oc...
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Open Access DOI:10.23937/2378-3419/3/1/1040
Iris Atzmon, Shai Linn, Elihu D Richter and Boris Portnov
Article Type: Research Article | First Published: January 30, 2016
Scientific debate regarding the health effects of Microwave/Radiofrequency (MW/RF) radiation has continued for decades, but has risen sharply in recent years due to an explosion in wireless technology. Several studies of the health effects of MW/RF radiation were published in recent years, but their results have not been analyzed to date using meta-analysis tools....
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Open Access DOI:10.23937/2378-3419/3/1/1039
Iris Atzmon, Boris Portnov, Shai Linn and Elihu D Richter
Article Type: Research Article | First Published: January 27, 2016
Scientific debate regarding health effects from MW/RF radiation has increased considerably in recent years. In the early 1980's much of the evidence concerning the health effects of MW/RF radiation came from occupational studies, however, in the 1990's and the 2000's, environmental studies became more dominant. This resulted from an increase in public awareness about exposure to MW/RF radiation....
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Open Access DOI:10.23937/2378-3419/3/1/1038
Yuko Takami, Susumu Eguchi, Masaki Tateishi, Tomoki Ryu, Kazuhiro Mikagi, Yoshiyuki Wada and Hideki Saitsu
Article Type: Original Article | First Published: January 11, 2016
Background: Generally it is rare to select surgery for treating breast cancer liver metastases (BCLM), but we have carried out aggressively surgical treatment to BCLM. Especially as a part of treatment strategies, we have used intraoperative loco-regional microwave ablation, named microwave coagulo-necrotic therapy (MCN). In this study, we investigate whether or not surgical treatment, combining hepatic resection and/or MCN, is useful for treating BCLM. Methods: Between 1994 and 2014, 33 patient...
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Open Access DOI:10.23937/2378-3419/3/1/1037
Renty B. Franklin, Jing Zou, Yao Zheng, Michael J. Naslund, Leslie C. Costello
Article Type: Research Article | First Published: January 09, 2016
Prostate cancer remains the second leading cause of cancer deaths in males. This is mainly due to the absence of an available efficacious chemotherapy despite decades of research in pursuit of effective treatment approaches. A plausible target for the treatment is the established clinical relationship that the zinc levels in the malignant cells are markedly decreased compared to the normal epithelium in virtually all cases of prostate cancer, and at all stages malignancy. The decrease in zinc re...
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Issue 1