Massive Arterial Bleeding after Lenvatinib Therapy for Thyroid Cancer
Koichi Suyama, DaizoMurakami, Saori Fujiwara, Takashi Takeshita, Aiko Sueta, ToukoInao, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Shin-yaShiraishi and Hirotaka Iwase
Article Type: Clinical Image | First Published: November 26, 2016
A 69-year-old woman presented with hoarseness and other symptoms of laryngeal stenosis. A palpably large tumorin her neck was shown by computed tomography (CT) to expand invasively from her upper left thyroid lobe, and to involve her left common carotid artery and internal jugular vein (Figure 1 A-1). The diagnosis of papillary thyroid cancer was based on cytological evidence from fine needle aspiration biopsy....
Pigmented Paget Disease of the Nipple: A Rare Breast Cancer Presentation
Santiago Sherwell-Cabello, Antonio Maffuz-Aziz, Silvia Natalia Lopez-Hernandez, Melissa Lizeth Flores-Cortes, Veronica Bautista-Pina and Sergio Rodriguez-Cuevas
Article Type: Short Review | First Published: November 26, 2016
Institutional board approval was obtained before commencement of this study. A retrospective study was conducted in all women diagnosed with breast cancer at our institution from January 2005 to December 2013. Standard immunohistochemical breast cancer panel was performed to all patients (ER, PR, Her-2 and Ki-67) and CK-7, P63 and S-100 when the pigmented variety was presented. Patients with pigmented Paget disease were selected and demographic characteristics were established....
Colorectal Cancer Aggressiveness is Related to Fibronectin Over Expression, Driving the Activation of SDF-1:CXCR4 Axis
Sofia Gouveia-Fernandes, Tania Carvalho, Germana Domingues, Renata Bordeira-Carrico, Sergio Dias and Jacinta Serpa
Article Type: Review Article | First Published: November 19, 2016
Cancer hallmarks result from dynamical interactions between tumor cells and tumor microenvironment, including normal cells, growth factors and extracellular matrix (ECM) components. Fibronectin (FN) is a high molecular weight, multidomain glycoprotein, present as a soluble form in body fluids, such as plasma (plasma FN), and as an insoluble form in ECM (cellular FN)....
Prolonged Use of Aprepitant in Metastatic Breast Cancer and a Reduction in CA153 Tumour Marker Levels
Mark Lee, Matthew McCloskey and Stephanie Staples
Article Type: Case Report | First Published: November 16, 2016
Nausea and vomiting are common problems in patients with advanced cancer. This case report describes a patient whose refractory nausea and vomiting improved significantly with the use of Aprepitant, a highly selective neurokinin 1 receptor antagonist. This improvement led to prolonged daily administration, during which time no chemotherapy or hormone therapy was administered. CA153 tumour markers were noted to have fallen during administration....