Open Access DOI:10.23937/2378-3419/1410107
Family History of Breast Cancer Associated with Breast Cancer in Survivors of Hodgkin Lymphoma
Sarah Colonna, Karen Curtin, Eric Johnson, Wendy Kohlmann, Jennifer Wright, Anne Kirchhoff, Sean Tavtigian and Joshua Schiffman
Article Type: ORIGINAL RESEARCH | First Published: February 25, 2019
Advances in treatments for Hodgkin Lymphoma (HL) have significantly increased survival of childhood and adult patients; however, the leading cause of death in HL survivors is due to secondary malignancy following HL treatment. Among women treated for HL, breast cancer (BC) is the most common secondary malignancy. We explored if an association exists between HL and BC exists within families. ...
Open Access DOI:10.23937/2378-3419/1410106
Awareness Level, Knowledge and Attitude towards Breast Cancer between Medical and Non-Medical University Students in Makkah Region: A Cross Sectional Study
Ramya Ahmad Sindi, Asmaa Ahmad Alzahrani, Nesreen Abdullah Alzahrani, Rana Ahmad Bin Salman, Shaimaa Amer Alshareef, Aisha Tabassum and Mohammad Shahid Iqbal
Article Type: Research Article | First Published: February 21, 2019
The worldwide cancer incidence and mortality has rapidly increased in the last decade. The cancer burden globally estimated to have crossed 18.1 million new cases and 9.6 million deaths in 2018. As per the report of GLOBOCAN 2018, the worldwide incidence of breast cancer is 2.08 million and deaths due to breast cancer are 6.3 lakhs. With these figures, breast cancer is the most common cancer diagnosed among women worldwide accounting for 24.2% of all cancers diagnosed in women. As per WHO countr...
Open Access DOI:10.23937/2378-3419/1410105
Impact of a Dedicated Multidisciplinary Research and Treatment Network on Outcomes of Muscle-Invasive Bladder Cancer Patients
Debbie G Robbrecht, Rob HA Verhoeven, Peter de Vries, Michiel S van der Heijden, Joost L Boormans and Ronald de Wit (on behalf of the Dutch Uro-oncology Study group (DUOS))
Article Type: Original Article | First Published: February 09, 2019
Our retrospective analysis based on 3472 muscle-invasive bladder cancer patients, showed a non-significant trend towards survival benefit when treated in hospitals involved in a national study-group network (DUOS), with significantly superior outcomes concerning neo-adjuvant chemotherapy, surgical margins and lymph node dissection. These factors significantly correlated with an improved survival, favoring treatment at centers that are involved in a multidisciplinary national network with dedicat...
Open Access DOI:10.23937/2378-3419/1410104
Exemestane-Induced Eosinophilic Colitis in a Patient with Grade 3 Ductal Carcinoma In-Situ: A Case Report and Review of the Literature
Kristyn Sanders, Shannon Lim, Sandra Ortega RN, Mark Gimbel and Lida Mina
Article Type: Case Report | First Published: February 07, 2019
Approximately after three months of exemestane therapy for breast cancer risk reduction, a 60-year-old female with estrogen receptor positive, right breast ductal carcinoma in situ (DCIS) presented to the emergency room with severe abdominal pain, nausea, vomiting, and diarrhea. Imaging studies revealed severe colitis of the transverse colon. No other medications were started except for exemestane that would have contributed to the patient's symptoms. Outpatient workup included stool cultures, l...
Open Access DOI:10.23937/2378-3419/1410103
Αβ-Crystallin and Laminin-332 are Prognostic Markers for Triple Negative Breast Cancers in a Brazilian Series
Marcia S Graudenz, Diego M Uchoa, Ermani Cadore, Juliana Giacomazzi and Sidia Maria Callegari-Jacques
Article Type: Research Article | First Published: February 01, 2019
Association between increased αβ-crystallin (ABC) and abnormal LN332 (LN332) expression in triple negative (TNBC) and basal-like (BLBC) breast cancers has been suggested recently. This study aims to evaluate ABC and LN332 immunohistochemical expression in a series of TN infiltrating ductal breast carcinomas and its association with clinical-pathological features and prognostic significance. Microarrays of 69 cases of TNBC cases were scored for the expression of ABC, LN332, CK5/6 and EGFR by im...
