Expression of P53 and Prognosis in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)
Amlani Lahin, Bellile Emily, Spector Matthew, Smith Joshua, Brenner Chad, Rozek Laura, Nguyen Ariane, Zarins Katie, Thomas Daffyd, McHugh Jonathan, Taylor Jeremy and Wolf T Gregory
Article Type: Original Article | First Published: August 09, 2019
Mutation of TP53 is the most common genetic abnormality in head and neck squamous cell carcinoma (HNSCC) and results in an accumulation and expression of p53 protein in tumor cells. Disruptive TP53 mutations are consistently associated with poor prognosis but correlations of p53 expression with mutation or prognosis have been variable and the usefulness of p53 as a target for immunotherapy is unknown. Favorable prognosis is associated with the accumulation of T lymphocytes (TILs) in the tumor mi...
Early Aggressive Management of Postoperative Pancreatic Fistulas following Pancreaticoduodenectomy (PD): A Five-Year Single Institution Experience
Rohan Thakkar, FRCS, David Bourne, Msc, Stacey Vass, Bsc, Aditya Kanwar, FRCS, Theodore Tsirilis, FRCS, John S Hammond, PhD, Colin Wilson, PhD, Gourab Sen, MD, Steven White, MD, Jeremy French, MD, Richard Charnley, DM and Derek Manas, FRCS
Article Type: Original Article | First Published: August 07, 2019
We retrospectively analysed the data that underwent PD between 2013-2017. We reviewed for all patients who experienced Grade B POPF. Data included details of total parenteral nutrition received, dose of octreotide infusion administered, serial drain amylase levels, effluent volume and anthropometry. Outcome measures were weight changes associated with treatment, the number of lines used per patient, the length of treatment, treatment associated complications and 90-day mortality rates....
Performance of Three Prognostic Models in Critically Ill Patients with Cancer: A Prospective Study
Frank D Martos-Benitez, PhD, MD, Hilev Larrondo-Muguercia, MD, David Leon-Perez, MD, Juan C Rivero-Lopez, MD, Versis Orama-Requejo, MD and Jorge L Martinez-Alfonso, MD
Article Type: Original Article | First Published: July 17, 2019
Predicting mortality is one of the greatest challenges for critical care physicians. Severity scoring systems integrate clinical data to estimate the probability of death, which can be used to facilitate resource utilization or continuing quality improvement and to stratify patients for clinical research. Prospective validation in different populations of critically ill patients improves the applicability of the model to these settings. Furthermore, the performance of a prognostic score must be ...