Prognostic Significance of Hormone Receptor (ER/PR) Status Inendometrial Carcinoma in Black Women: Implications with Lymph Node Metastasis
Manan Shah, Gabriela Oprea, Saba Shafi, Phani Keerthi Surapaneni, Sandeep Sasidharan, and Sanjay Jain
Article Type: Original Research | First Published: April 19, 2021
Loss of estrogen and progesterone receptors (ER/ PR) independently predicts lymph node metastasis and poor prognosis. Black females in comparison to their white counterparts are diagnosed at a later stage, with higher grade, poorer prognostic histology, and worse outcomes. We reviewed black females (n = 70) diagnosed with endometrial cancer at our institution from 2015-2018 including endometroid/ non-endometroid histology, FIGO stage I-IVA, grade 1-3 for ER/PR receptors and presence or absence o...
HER2/Neu Distribution in Female Breast Cancer in Libya: Correlation with Clinicopathological Features and Survival
Abdalla O Jebriel, Jens Huober and Fathi B Abdalla
Article Type: Original Article | First Published: April 18, 2021
HER2 protein over-expression is of great importance to guide hormone therapy. The present study aimed to determine the HER2 status of Libyan women with breast cancer and evaluate the correlation of HER2 expression with some clinicopathological features as well as overall survival (OS). Data on 245 women with a diagnosis of breast cancer who were registered at the Misurata Cancer Center (MCC) in Libya from January 2004 to December 2012 were retrospectively studied. Patients’ demographic and cli...
Metastatic Tfe3-Overexpressing Renal Cell Carcinoma: Case Report and Literature Review
Paulo Victor Zattar Ribeiro, Leonora Zozula Blind Pope, Beatriz Granelli, Milena Luisa Schulze, Andréa Rodrigues Cardovil Pires and Mateus da Costa Hummelgen
Article Type: Case Report | First Published: March 19, 2021
Renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 RCC) is a rare subtype of RCC which is delineated as a distinct entity in the 2004 World Health Organization renal tumor classification. To highlight a rare case, with few publications on the topic, in addition to providing scientific explanations about it. This is a case report of a 58-year-old white male with the diagnosis of renal clear cell carcinoma (RCC). The immunohistochemistry was performed and show...
Triple Chemotherapy (DOX) in Patients with Advanced Gastro- Esophageal Adenocarcinoma - A Phase II Study
Tarpgaard LS, Jensen M, Schønnemann KR, Jensen HA, Yilmaz M and Pfeiffer P
Article Type: Original Research | First Published: March 19, 2021
Triple chemotherapy improves efficacy in patients with advanced gastro-esophageal (GE) cancer. In a phase I dose- finding trial including 23 patients we established a recommended dose of triple chemotherapy with docetaxel (D), oxaliplatin (O), and capecitabine (X) (DOX). We found promising activity and here we present efficacy data from the succeeding phase II trial. Patients and Methods: All patients had histologically confirmed GE adenocarcinoma. Therapy was docetaxel (51 mg/m2 as a 60 minutes...