International Journal of

Cancer and Clinical ResearchISSN: 2378-3419


 Open Access DOI:10.23937/2378-3419/1410178

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

Dávid Fodor, Eva Pozsgai, Andrew V. Schally, Zoltán László, Éva Gömöri, Éva Szabó, László Rumi, Dorottya Lőcsei, Árpád Boronkai and Szabolcs Bellyei

Article Type: Review Article | First Published: December 31, 2022

Rectal cancer constitutes nearly one-third of all colorectal cancer diagnoses and certain clinical and molecular markers have been studied as potential prognosticators of patient survival. The main objective of our study was to investigate the relationship between the expression intensities of certain proteins: Growth Hormone- Releasing Hormone Receptor (GHRH-R), Hsp90, Hsp16.2, p-Akt and SOUL in specimens of locally advanced rectal cancer patients and time to metastasis as well as 10-year Ove...

 Open Access DOI:10.23937/2378-3419/1410177

Colorectal Cancer Screening: Ratios from Hemogram to the Rescue

Purva Trivedi, Mahesh Patel, Sanjay Dhotre and Hansa Goswami

Article Type: Original Article | First Published: October 20, 2022

Colorectal Cancers (CRC) are one of the top ten cancers to increase the burden on the health care system in India. Often patients experience symptoms after carcinoma has significantly progressed. Timely and accurate screening in the target population remains a challenge for clinicians....

 Open Access DOI:10.23937/2378-3419/1410176

The Role of Adjuvant Metronomic Chemotherapy in Increasing Overall Response Rate in Patients with Breast Cancer

Bhushan Jain and Akhila Pakalapati

Article Type: Review Article | First Published: September 18, 2022

Treatment paradigms against cancer have continuously evolved over the years. Having said that, with its prevalence of more than 2 million cases each year, breast cancer represents an urgent global priority [1]. Breast carcinomas accounted for 11.6 % of cancer cases and were the cause of mortality in as many as 6.6 % of women in the world in 2018 [2]. Toxicity and chemoresistance are significant hurdles in conventional chemotherapy and to avoid these issues, a new approach to drug administration,...

 Open Access DOI:10.23937/2378-3419/1410175

Awareness of Breast Cancer and Practice of Breast Self- Examination Amongst Female Students of a Tertiary Institution in South-South Nigeria

Alabrah PW, Eguvbe AO, Agbo J and Allagoa DO

Article Type: Original Article | First Published: August 19, 2022

Breast cancer is the leading cause of cancer deaths presently, representing about 23% of all cancer cases and approximately 18% percent of deaths are attributed to it in Nigeria. It is presently the most prevalent kind of cancer worldwide, with 2.26 million cases reported in 2020. Breast Self-Examination (BSE) is a way to watch for signs of breast cancer....

 Open Access DOI:10.23937/2378-3419/1410174

Malignant Neural Sheath Tumors of the Head and Neck

Carlos Santiago Ruggeri, Gabriel Rondón Gonzalez, Ana Clara Ragoni and Inés Fagalde

Article Type: Research Article | First Published: August 19, 2022

Malignant neural sheath tumors located in the head and neck region are very rare. Surgical treatment if possible is the best option, trying to obtain wide resection margins free of tumor. To determine the incidence of malignant tumors of neural histology, in relation to nerve tumors originating in the head and neck and description of two clinical cases....

 Open Access DOI:10.23937/2378-3419/1410173

Proposed Experimental Preparation and Administration of Dendritic Cell Vaccine for Treatment of Cancer (Metastatic Castration-Resistant Prostate Cancer)

Behzad Niakan

Article Type: Letter to Editor | First Published: July 09, 2022

It is suggested that a cause of inefficacy in dendritic cell vaccine is dendritic cell dysfunction. It is proposed that dendritic cell dysfunction is possibly due to the immuneregulatory function of activated platelets in cancer patients. It is suggested that activated platelets in cancer patient suppress dendritic cell activity against a malignant growth. A low platelet count prior to the removal of dendritic cells would possibly yield less dysfunctional dendritic cells....

 Open Access DOI:10.23937/2378-3419/1410172

Proposed Biology of the Spontaneous Remission of Merkel Cell Carcinoma after Biopsy

Behzad Niakan

Article Type: Letter to Editor | First Published: July 08, 2022

The medical literature has many case reports of the spontaneous remission of Merkel cell carcinoma after biopsy. It is noteworthy that prior to the biopsy the Merkel Cell Carcinoma was growing rapidly. It is suggested that the biopsy has possibly resulted in the breakage of a vessel and blood loss within the malignant tissue....

 Open Access DOI:10.23937/2378-3419/1410171

The Impact of Chemotherapy Schedule Modification on Survival Outcome among Breast Cancer Patients Receiving Adjuvant or Neoadjuvant Treatment Modalities

Gobi Hariyanayagam Gunasekaran, Wan Mohd Akmal Bin Wan Sabri, Shargunan Selvanthan Gunasekaran, Sera Selvanthansundram Gunasekaran and Kavisha Selvarajoo

Article Type: Research Article | First Published: July 08, 2022

Chemotherapy schedule has been reported to increase the risk of suboptimal outcomes among cancer patients receiving chemotherapy with variying outcome between treatment modality. This study investigates the Overall Survival (OS) and Hazard of Death (HR) of breast cancer patients with chemotherapy schedule modification stratified against adjuvant (ACT) and neoadjuvant (NACT) treatment modalities....

Volume 9
Issue 2