International Journal of

Diabetes and Clinical ResearchISSN: 2377-3634

Archive

 Open Access DOI:10.23937/2377-3634/1410024

Assessment of Circulatory Levels of Endothelin-1 in Diabetic Subjects Screened Through a Cross Sectional Study from Rural Women in Bangladesh

Md. Arifur Rahman, Subrina Jesmin, Chishimba Nathan Mowa, Farzana Sohae, Junko Kamiyama, AKM Ahsan Habib, Nobutake Shimojo, Md. Majedul Islam, Masao Moroi, Osamu Okazaki, Naoto Yamaguchi, Satoru Kawano, Taro Mizutani and Yoshio Iwashima

Article Type: Research Article | First Published: February 26, 2015

Endothelin-1 (ET-1), a potential marker of endothelial dysfunction, has been shown to be elevated in diabetic mellitus (DM) subjects. However, to date, the circulatory profile of ET-1 and its association with DM have not been investigated in any South Asian country, including Bangladesh. The present study assessed circulating levels of ET-1 in subjects with or without DM and further examined the association of ET-1 with clinical and metabolic parameters in Bangladeshi rural women....

 Open Access DOI:10.23937/2377-3634/1410023

An Oral Antioxidant Formulation Delaying and Potentially Reversing Canine Diabetic Cataract: A Placebo Controlled Masked Pilot Study

David Williams, Angus Fitchie and Carmen Colitz

Article Type: Clinical Trial | First Published: February 24, 2015

The majority of dogs with diabetes mellitus develop blinding mature cataracts through the action of the enzyme aldose reductase producing sorbitol with osmotic action drawing water into the lens thus causing opacification. ...

 Open Access DOI:10.23937/2377-3634/1410022

Self-Care among Diabetic Amputee

David Berbrayer

Article Type: Research Article | First Published: February 23, 2015

Background: Diabetic amputees are at increased risk for receiving a second amputation, which may be prevented by proper selfcare. Although existing literature suggests self-care is inadequate among diabetic patients, self-care behaviour after an amputation is unknown. This study aims to identify strategies used by diabetic patients who received a lower-extremity amputation to prevent further amputation. Method: A cross-sectional survey was conducted on patients over 18 years of age who were regi...

 Open Access DOI:10.23937/2377-3634/1410021

Early Release of HMGB1 may Aggravate Neuronal Damage after Transient Focal Ischemia in Diabetic Rat Brain

Naohiro Iwata, Mari Okazaki, Shinya Kamiuchi, Meiyan Xuan, Hirokazu Matsuzaki, Takeshi Sakamoto and Yasuhide Hibino

Article Type: Research Article | First Published: February 22, 2015

Objective: High Mobility Group Box 1 (HMGB1) released extracellularly from necrotic cells evokes delayed inflammatory processes via interaction with the Receptor for Advanced Glycation End Products (RAGE) or Toll-like Receptors (TLR) in postischemic brain. The diabetic state (DM) aggravated cerebral ischemic injury following the stroke in rats. Therefore, we examined the behavior of HMGB1 and the expression of RAGE in non-DM and DM rat brain after middle cerebral artery occlusion followed by rep...

 Open Access DOI:10.23937/2377-3634/1410020

Torpid Diabetic Wound Healing: Evidence on the Role of Epigenetic Forces

Jorge Berlanga-Acosta, Yssel Mendoza-Mari, Maday Fernandez-Mayola, Ariana GarciaOjalvo, Calixto Valdes-Perez, William Savigne-Gutierrez, Daniel Reynaldo-Concepcion, Ileydis Iglesias-Marichal, Angel Abreu-Cruz, Celso Suarez-Lescay, Ana Mir-Benitez, Natacha Sancho-Soutelo and Luis Herrera-Martinez

Article Type: Research Article | First Published: January 29, 2015

The increasing number of diabetes patients represents a health challenge due to disease-related, end-organs complications. Hyperglycemia is considered the proximal trigger of an intricate cascade of molecular processes that progressively deteriorate tissues and organs, leading to the onset of clinical complications. Lower extremity ulcerations and their ensued refractoriness to heal can potentially result in amputation and disability and remain the second most feared diabetic complication. We ha...

 Open Access DOI:10.23937/2377-3634/1410019

Magnesium and Type 2 Diabetes: An Update

Mario Barbagallo and Ligia J. Dominguez

Article Type: Review Article | First Published: January 26, 2015

The link between magnesium (Mg) deficiency and type 2 diabetes mellitus is well known. Type 2 diabetes is frequently associated with both extracellular and intracellular Mg deficits. A chronic latent Mg deficit or an overt clinical hypomagnesaemia is common in subjects with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-gl...

 Open Access DOI:10.23937/2377-3634/1410018

Relationship between Type of Family and its Relationship to Metabolic Control in Patients with Type 2 Diabetes Mellitus

Ixba-Villegas Mario Alberto, Marquez-Gonzalez Horacio, Jimenez-Baez Maria Valeria and Cantellano-Garcia Diana Michelle

Article Type: Research Article | First Published: January 16, 2015

Objective: To estimate the association between familiar function and metabolic control in patients with T2DM treated in a DiabetIMSS module in a first-level medical unit in Cancun, Quintana Roo, Mexico. Methods: A cross-sectional, prospective and analytical study was conducted. In patients with T2DM and the target population included patients with T2DM who attended the module DiabetIMSS in Cancun, Quintana Roo. Included patients with T2DM between 20 and 80 years of age who received attention in ...

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