Subcutaneous Insulin Safety Concerns
Article Type: Short Commentary | First Published: September 29, 2018
With the growing prevalence of type 2 diabetes in the United States, the use of insulin has increased along with the incidence of needle-stick injuries. The Institute for Safe Medication Practices (ISMP) published guidelines in 2017 on how to optimize safe subcutaneous insulin use in adults. One of the recurring themes of these guidelines is education, education, education. This is essential for self-management by patients with diabetes and also for the safety and effectiveness of the care they ...
The Effect of Vitamin D Supplementation on Blood Lipids in Minorities with Type 2 Diabetes
Joel C. Exebio, Sahar Ajabshir, Adriana Campa, Tan Li, Gustavo G. Zarini and Fatma G. Huffman
Article Type: Original Research | First Published: September 29, 2018
Vitamin D deficiency and type 2 diabetes are common among Hispanics and African Americans in the US. The aim of the study was to determine the effect of supplemental vitamin D intake (4000 IU/day or 6000 IU/day of vitamin D3 over a 6-month period) on blood lipids in a sample of African Americans and Hispanics with type 2 diabetes and vitamin D insufficiency. Participants (n = 75) were recruited by community outreach. Participants in both groups were required to take either 4000 IU or 6000 IU of ...
The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes
Article Type: Review Article | First Published: September 06, 2018
It has been shown that metabolic-based therapies, such as nutritional ketosis, are effective to contrast seizure disorders and various acute and chronic neurological disorders. From a physiological perspective, glucose is the primary metabolic fuel for cells. However, many neurodegenerative disorders have been recently associated with impaired glucose transport and metabolism and with mitochondrial dysfunction causing energy deficits, such as in Alzheimer's disease, Parkinson's disease, general ...
Histopathological Alteration in STZ-Nicotinamide Diabetic Rats, a Complication of Diabetes or a Toxicity of STZ?
Nahid MH Elamin, IMT Fadlalla, Shadia A Omer and Hala AM Ibrahim
Article Type: Original Article | First Published: September 06, 2018
Type 2 diabetes mellitus (T2DM) previously known as non-insulin dependent diabetes mellitus is the most common type of diabetes mellitus. The rapid increasing prevalence, high morbidity and mortality of the disease must be encountered by an increase in scientific research. Animal models are very important in the preclinical studies to validate the use of new drugs. Streptozotocin - nicotinamide (STZ-NA) is used to induce T2DM in animals....
Insulin Regulates Circulating Omentin, Fatty Acid Binding Protein-4 and Chemerin, but not Irisin in Man
Nandita K Shankar, Clayton A Dehn, Robert V Considine and Helmut O Steinberg
Article Type: Research Article | First Published: July 23, 2018
Omentin, fatty acid binding protein-4 (FABP-4), chemerin and irisin are chemokines whose circulating levels are altered in insulin resistant states. However, there is limited insight into function of these chemokines as well as the potential role of insulin in the modulation of these chemokines. We tested the hypothesis that insulin alters these chemokines by measuring changes in their circulating levels in response to elevated insulin in a group of healthy non-obese subjects....