Type 3 Diabetes? Evaluation of the Noradrenergic System in Diabetic Rats by Underexpression of Tyrosine Hydroxylase in the Central Nervous System
Géssica De Mattos Diosti Klockner, Fernanda Christo Lovato, Rebeca Loureiro Rebouças, Laura Ingrid Volkweis Langer, Ingrid Oliveira Hoegen, Maria Luiza Ronkoski, Stephanie Rubianne Silva Carvalhal, Luiz Martins Collaço, Camila Marques and Luiz Fernando Kubrusly
Article Type: Original Article | First Published: December 09, 2021
Diabetes mellitus (DM) is a chronic inflammatory state that leads to potentially degenerative changes in brain metabolism. Sustained pictures of hypoinsulinemia trigger phosphorylation of the tau protein and production of amyloid plaques, forming senile plaques and neurofibrillary tangles in brain tissue. Diabetic patients have a higher incidence of cognitive impairment and a higher risk of developing Alzheimer's Disease (AD), the most common type of dementia characterized by chronic neurodegene...
Therapeutic Efficacy and Antihyperglycemic Properties of Catharanthus roseus for Diabetes Mellitus: A Systematic Review
Article Type: Review Article | First Published: December 09, 2021
Diabetes mellitus refers to a group of metabolic diseases, in which the patient experiences high levels of blood glucose due to an insufficient production of insulin by the pancreas (Type I diabetes) or an inability of his/her body to respond to the insulin produced (Type II diabetes). Catharanthus roseus (C. roseus) is a plant that belongs to the Apocynaceae family, and has long been used as a natural medicine for Type-1 and Type-2 diabetes in the Ayurvedic system of medicine. This systematic r...
Screening of Diabetic Patients for Frailty with the Frail Scale: A Comparison with the Fried’s Phenotype Criteria in Saudi Arabia
Sadiq Ahmed Al-Ali, Qasem Mohammed AlJabr, Zainab Tariq Alramadhan, Zainab Algharrash, Alhawraa Jassim Ahmad Alyousif, Aroob Nassir Alessa and Hassan Ali AlButayan
Article Type: Research Article | First Published: October 03, 2021
Frailty is a serious health issue that is associated with the decline of muscle and nerve functions. Several conditions have been associated with frailty, such as dementia, cancer, and diabetes. The aim of the study is to evaluate the prevalence of frailty in Saudi diabetic patients and assess the association between diabetes and frailty. Also, to investigate if the FRAIL scale is an adequate tool to identify frail patients to pre-frail and healthy patients. Seventy-eight participants were divid...