Open Access DOI:10.23937/2378-3672/1410074
Role of Immune Components and Immunotherapy in Prostate Cancer Treatment
Pradeep Kumar and Sujeet Kumar Mewar
Article Type: Review Article | First Published: 2024/11/04
Prostate cancer (PCa) is a prevalent malignancy among men, with advanced stages often presenting significant treatment challenges despite traditional therapies such as surgery, radiation, and hormone therapy. Recent advancements in immunotherapy have introduced new strategies to harness the immune system's potential in combating this disease. This review explores the roles of various immune components in PCa and evaluates the impact of emerging immunotherapeutic approaches. Immune components, in...
Open Access DOI:10.23937/2378-3672/1410073
NMR-Based Blood Metabolomic Profiling and Immunological Parameters to Identify Early Biomarkers for Prostate Cancer Bone Metastases
Pradeep Kumar, Virendra Kumar, Rajeev Kumar, Sanjay Sharma, Sanjay Thulkar and MA Khan
Article Type: Research Article | First Published: 2024/10/12
Metastasis to the bone is one clinically important feature of prostate cancer (PCa). Since PCa is treatable, existing diagnostic techniques are unable to predict metastatic disease. Identification of metabolic pathways involved in the growth of bone metastasis, therefore, has the potential to improve PCa prediction and treatment. Consequently, clinical treatment will benefit from sensitive and specific cancer biomarker/s for PCa bone metastases that may be used for diagnosis and prognosis. To in...
Open Access DOI:10.23937/2378-3672/1410072
Prevalence and Associated Factors of Hemorrhoid and Other Perianal Complications during Puerperium among Mothers in Debre Tabor Referral Hospital, Ethiopia: A Cross-Sectional Study
Anemut Tilahun Mulu, Awgchew Behaile Teklemariyam, Zelalem Tilahun, Nega Dagnew, Alebachew Amsalu, Birhanu Mengist, Mezgebu Legesse, Abebe Muche Belete and Melaku Mekonnen Agidew
Article Type: Review Article | First Published: 2024/03/28
Puerperium is defined as the period of six weeks after child birth during which the mother's reproductive organs return to their original non-pregnant condition. Perianal problems including Constipation, Hemorrhoid and Fissure are among the most common complications among women during puerperium, observed in about 30 to 50 percent of women. Considering this great prevalence and the paucity of similar research in Ethiopia, this study was done to assess the prevalence of perianal problems during p...
Open Access DOI:10.23937/2378-3672/1410070
The Ageing Immune System- Implications for COVID-19
Kelechi Ukaegbu
Article Type: Review Article | First Published: 2024/03/04
Ageing is a slow and continuous process that is associated with the decline in the functioning immune system. These changes are now recognized and appreciated under the canopy term ‘Immuno-senescence’ [1]. Immuno-senescence is not due to a lack of immune cells but reduced diversity in the repertoire - with reduced naive cells and increased memory cells. Secondly, the ageing immune system is subject to inflammaging, elevated self-reactivity leading to chronic low-grade inflammation....
