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International Journal of

Immunology and ImmunotherapyISSN: 2378-3672

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 Open Access DOI:10.23937/2378-3672/1410010

Fatal Good's Syndrome: Report of Two Cases

Musabak Ugur, Kartal Ozgur, Demirel Fevzi, Gulec Mustafa, Safali Mukerrem, Battal Bilal, Nevruz Oral, Baysan Abdullah, Yesillik Sait, Karaman Murat and Sener Osman

Article Type: Case Report | First Published: May 20, 2015

Good's syndrome (GS) that consists of hypogammaglobulinemia and thymoma is a rare adult-onset disease. Some paraneoplastic syndromes like pure red cell aplasia (PRCA) and myasthenia gravis (MG) may accompany to this immunodeficiency disease. We herein reported two fatal cases of GS....

 Open Access DOI:10.23937/2378-3672/1410009

The Challenge of Eosinophilic Esophagitis

Jeremiah Levine

Article Type: Opinion | First Published: April 03, 2015

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder characterized by eosinophilic inflammation of the esophagus. Although the underlying etiology is unknown, EoE is thought to be a TH2 response to environmental allergens in a genetically predisposed individual....

 Open Access DOI:10.23937/2378-3672/1410008

Identifying Toll-Like Receptor Expression in Molluscum Contagiosum

Maria Yaldo, Katherine Caretti, Jessica Kado and Darius R Mehregan

Article Type: Research Article | First Published: March 31, 2015

Toll-like receptors (TLRs) are known to be involved in the immunogenic response in a variety of dermatological disorders including psoriasis, condyloma acuminata, atopic dermatitis, and cutaneous T-cell lymphoma. However, the expression of TLRs in Molluscum contagiosum has not yet been clearly defied.Expression of TLRs 1-9 was examined in molluscum by immunohistochemical staining....

 Open Access DOI:10.23937/2378-3672/1410007

Persistent Complement Activation is Associated with Insulin Resistance and Chronic Inflammation in Overweight Patients with Type 2 Diabetes with Dyslipidemia

Takayuki Fujita, Yusuke Murata, Seiichiro Hemmi, Mamiko Kajiwara, Minako Yabuki, Yoshinobu Fuke, Atsushi Satomura and Masayoshi Soma

Article Type: Original Article | First Published: March 31, 2015

Insulin resistance is a major player in the pathogenesis of type 2 diabetes. C3 converts to C3a and acylation stimulating protein (ASP) by complement activation. ASP activates adipose tissue macrophages and accelerates continuous inflammation. Tissuebound C3a is known to induce insulin resistance. We examined the relationship between insulin resistance and complement activation by the in vivo alteration of ASP....

 Open Access DOI:10.23937/2378-3672/1410006

A Critical Review of Steroid Immunotherapy in Kidney Transplantation

Oluwatoyin Bamgbola

Article Type: Review Article | First Published: March 21, 2015

Steroid immunosuppression has maintained a long-lasting relevance in renal transplantation. In addition to its role in preserving allograft survival, it is often the fist line agent in the rescue treatment of acute rejection events. Its major drawbacks include metabolic adverse effects and long-term cardiovascular morbidities. Motivated by the need to avoid growth impairment, pediatric renal transplant community provided a template for steroid minimization strategy....

 Open Access DOI:10.23937/2378-3672/1410005

Preferential Expansion of Th1 type-CD56+Vγ9γᵨT Cells by CD56high+IFNα-induced Dendritic Cells Derived from Cancer Patients in vitro and in vivo

Mie Nieda, Hiroshi Terunuma, Yuuta Eiraku, Xuewen Deng and Andrew J Nicol

Article Type: Original Research | First Published: February 05, 2015

The CD56+ cells freshly isolated from human peripheral blood contain a substantial subset of CD14+CD86+HLA-DR+ cells which spontaneously differentiate into enlarged DC (dendritic cell)-like cells. We show here that interferon-α (IFN-α)-induced DC-like cells expressing high levels of CD56 and CD14 can be differentiated from monocytes obtained as adherent cells from patients with various cancers, in the presence of IFN-α and granulocyte-macrophage colony stimulating factor (GM-CSF) ...

 Open Access DOI:10.23937/2378-3672/1410004

Development of a Method for Detection of Shigatoxin-Producing Escherichia coli Belonging to Clinically Important Twelve O Serotypes Based on the Combination of PickPen-Assisted Immunomagnetic Separation and Loop-Mediated Isothermal Amplification

Ahmad Yaman Kayali, Oscar Escalante-Maldonado, Varaporn Vuddhakul, Kazuko Seto, Yoshitsugu Nakaguchi, and Mitsuaki Nishibuchi

Article Type: Original Article | First Published: January 22, 2015

Not only O157 Shigatoxin-producing Escherichia coli (STEC) but some of non-O157 STECs are attracting attentions as clinically important STEC and a possible food-borne spread of these pathogens is becoming a worldwide concern. In this study, we developed a sensitive, specific, and simple method to detect STECs of clinical significance in retail beef so that it can be used even in resource-limited countries. We designed and fie-tuned a protocol characterized by PickPen devise-assisted immunomagnet...

 Open Access DOI:10.23937/2378-3672/1410003

Analyze the Levels of Immunoglobulins IgG and IgM in Elderly and Youngs

Samia Macedo Queiroz Mota Castellao Tavares, Wilame de Lima Bravo Junior and Jessica Lissandra Alves Leite

Article Type: Research Article | First Published: January 16, 2015

The aging process is complex and affects a variety of functions, including lower defense capability of the immune system. The immune activity, as most of physiological functions, decreases with age. The principal alterations in humoral immune response are associated with concentration of immunoglobulins, amount and activity of B cells and also the changes in the affinity of the antibodies. The current study aimed to analyze the levels of IgG and IgM antibodies of elderly and young people and to ...

Volume 2
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