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International Journal of

Immunology and ImmunotherapyISSN: 2378-3672

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 Open Access DOI:10.23937/2378-3672/1410025

Non-Specific Vaccination Exerts Anti-Tumor Effect through CD11c (+) Cells Stimulation in a Breast Cancer Model

Vanessa Elizabeth De Gregorio, Silvia Carino, Juan Carlos Valdez, Silvio Eugenio Castillo and Alejandra de Moreno de LeBlanc

Article Type: Research Article | First Published: December 07, 2016

A non-specific vaccine used as immunotherapy can be used to prolong an equilibrium phase in the tumor growth, similar to the doxorubicin treatment used in the model, although by different mechanisms. Non synergic effect was observed in the group treated with both vaccine and doxorubicin (low dose). Future studies should be necessary to evaluate the correct combination of vaccination and cytotoxic drug can be used for this purpose and to achieve increased activated dendritic cells in the tumor d...

 Open Access DOI:10.23937/2378-3672/1410024

Fast Updosing of Subcutaneous House Dust Mite Immunotherapy is Well Tolerated by Pediatric Patients

Alice Kohli, Martin Glatz and Peter Schmid-Grendelmeier

Article Type: Original Research | First Published: December 22, 2016

Data on the safety of a cluster regimen to start a subcutaneous immunotherapy (SCIT) with house dust mite (HDM) extract in pediatric patients are scarce. This study investigates the rate of adverse events (AEs) and the applicability of a cluster regimen for HDM SCIT in pediatric patients, and identifies possible risk factors for the development of AEs....

 Open Access DOI:10.23937/2378-3672/1410023

Epstein-Barr Virus (EBV) Encoded Dutpase Exacerbates the Immune pathology of Lupus Nephritis In Vivo

Nicholas A Young, Marshall V Williams, Wael N Jarjour, Michael S Bruss, Brad Bolon, Samir Parikh, Anjali Satoskar and Maria Eugenia Ariza

Article Type: Original Research | First Published: August 20, 2016

Epstein-Barr virus (EBV) is an environmental factor with strong links to systemic lupus erythematous (SLE) pathogenesis; however, the mechanism(s) remains unclear. The goal of this study was to determine whether the EBV protein "deoxyuridine triphosphate nucleotidohydrolase (dUTPase)", which can induce aberrant immune responses, contributes to the immunopathology of lupus nephritis (LN). Using the NZM2410/J SLE mouse model, we demonstrated that intramuscular injections of EBV-dUTPase protein (10...

 Open Access DOI:10.23937/2378-3672/1410022

Dextran-Conjugated Anti-Immunoglobulin Antibodies: A Powerful Tool for Studying B Cell Receptor-Mediated Signaling

Clifford M Snapper

Article Type: Mini Review | First Published: August 03, 2016

Anti-Ig-dex was originally conceived as a means for modeling BCR-mediated B cell activation in response to polysaccharides. Polysaccharides consist of long chains of repeating sugars that are capable of multivalent cross-linking of BCR on the surface of polysaccharide-specific B cells. Normal B cells of a given antigen-specificity are present in the host at frequencies so low that studying the behavior of such B cells is highly challenging technically....

 Open Access DOI:10.23937/2378-3672/1410021

Inhibition of Macrophage Activation and Lymphocyte Function of Annona vepretorum Mart. (Annonaceae) Natural Products

Tatiana Barbosa dos Santos, Cassio Santana Meira, Cibele do Carmo Miranda, Leociley Rocha Alencar Menezes, Livia Macedo Dutra, Liviane do Nascimento Soares, Andersson Barison, Emmanoel Vilaca Costa, Elisalva Teixeira Guimaraes and Milena Botelho Pereira Soares

Article Type: Original Article | First Published: July 27, 2016

Immunomodulatory drugs are widely used for the treatment of inflammatory and immune-mediated conditions; however, their prolonged use is usually associated with the appearance of side effects and many immune disorders continuous without a suitable treatment. Natural products are an important source of therapies to a variety of illnesses. The present work investigated the immunomodulatory activity of a hexane extract and isolated compounds from Annona vepretorum Mart....

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