International Journal of

Immunology and ImmunotherapyISSN: 2378-3672


 Open Access DOI:10.23937/2378-3672/1410053

Durable and Effectiveness of Immunotherapy in the Treatment of Metastatic Gastroesophageal Junction Cancer

Carlos Gil Moreira Ferreira, MBBS, Gustavo Bittencourt Camilo, Eleusa Nogueira Dias, Bianca Lopes de Oliveira, Carlos Murilo Schanuel, Juliana Abreu de Vasconcellos and Emílio Campos Augusto Pereira de Assis

Article Type: Case Report | First Published: July 09, 2020

Gastroesophageal junction adenocarcinoma (AJEG) is a neoplasm that is globally prevalent with generally bad clinical outcome. It is estimated that there is an annual incidence of new tumors in the order of 572,034 in the US with about 28,000 new cases and 10,960 deaths attributable to the disease. In Brazil, an estimated 11390 new cases, corresponding to 8690 in men and 2077 in women for the year 2020. About half of the people with cancer of the esophagus or the gastroesophageal junction have me...

 Open Access DOI:10.23937/2378-3672/1410052

COVID-19: A Cure and Preventive Options

Dr. Roli Jain and Dr. Archana Panday

Article Type: Review Article | First Published: June 29, 2020

The world encounters the episode of coronavirus infection that undetermined worldwide pandemic in 2002-2003 by Severe Acute Respiratory Syndrome (SARS) and in 2011 by Middle East Respiratory Syndrome (MERS). The genomic sequence of SARS-CoV-2 indicate similar, but distinct genome composition of SARSCoV and MERS-CoV. The World Health Organization (WHO) also declared a global emergency on January 31st due to increasing concerns over its fast spread, and on March 11th the disease was recognized as ...

 Open Access DOI:10.23937/2378-3672/1410051

A Systemic Review: Structural Mechanism of SARS-CoV-2A Promising Preventive Cure by Phytochemicals

Dr. Roli Jain, Dr. Sandeep Shukla, Dr. Neeti Nema and Dr. Archna Panday

Article Type: Review Article | First Published: June 24, 2020

Phytochemicals are a powerful group of compounds, belonging to secondary metabolites of plants and including a diverse range of chemical entities such as polyphenols, flavonoids, steroidal saponins, organ Sulphur compounds, and vitamins. The potential biological benefits such as antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal and antiviral activities. The ideal technology would be vaccine that gives lifelong immunity with a single dose. When whole world community of scienti...

 Open Access DOI:10.23937/2378-3672/1410049

Role of IL-17 and IL-23 in the Pathogenesis of Neutrophilic Asthma

Nightingale Syabbalo, MB, ChB, PhD, FCCP, FRS

Article Type: Review Article | First Published: May 21, 2020

Asthma is a complex chronic airway disease with several distinct phenotypes characterized by different immunopathological pathways, clinical presentation, physiology, comorbidities, biomarker of allergic inflammation, and response to treatment. Approximately 10% of patients with asthma have severe refractory disease, which is difficult to control on high doses of inhaled corticosteroids and other modifiers. About 50% of these individuals suffer from neutrophilic asthma. Neutrophilic asthma is a ...

 Open Access DOI:10.23937/2378-3672/1410050

Corona Virus: An Immunological Perspective Review

Nimesh Singh, Bharat Suthar, Abhay Mehta, Neeti Nema and Archna Pandey

Article Type: Review Article | First Published: May 22, 2020

As the world is seeing the plague of COVID-19, an illness brought about by a novel coronavirus, SARS-CoV-2, developing hereditary qualities and clinical confirmations recommend a comparative way to those of SARS and MERS. A course of viral particles enters the body through the nose, eyes or mouth. Breathing conveys a portion of these particles to the lower respiratory tract where the spike proteins of the coronavirus, acting like a key, lock into epithelial cells that line the respiratory tract ...

 Open Access DOI:10.23937/2378-3672/1410048

Association of Growth Differentiation Factor 5 (GDF5) Gene Polymorphisms with Susceptibility to Knee Osteoarthritis in Saudi Population

Amani A Alrehaili, Khadiga A Ismail, Ashjan Shami, Maha K Algethami, Hadeer W Elsawy and Amal F Gharib

Article Type: Original Research | First Published: May 08, 2020

Osteoarthritis (OA) is among the most prevalent joint diseases. Reduced patient life quality and productivity represent a major personal and community strains. GDF5 gene is involved in the development of bone and cartilage. Studies reported a clear and highly reproducible association between susceptibility of knee osteoarthritis (KOA) and GDF5. This study aims to detect GDF5 gene polymorphism and to evaluate its association with susceptibility to KOA....

 Open Access DOI:10.23937/2378-3672/1410046

An Immunological Algorithm to Defeat Covid-19

Ajay Gupta and Ayush Gupta

Article Type: Commentaries | First Published: April 27, 2020

Countries like Italy, Spain or Germany etc. with very low prevalence of tuberculosis and discontinued BCG immunization since decades, are witnessing the worst form of this global pandemic of Corona virus. It has also been seen that Covid-19 affected more of those countries who have robust and free influenza vaccination programme. High mortality of Covid-19 patients is probably result of the reduced Th1 immunity due to lack of past exposures to various infections and poor or absent local innate i...

 Open Access DOI:10.23937/2378-3672/1410045

Blood Plasma from Survivors of COVID-19: A Novel and Next Frontier Approach to Fight against Pandemic Coronavirus

Nimesh Singh and Archana Pandey

Article Type: Review Article | First Published: April 26, 2020

Blood from people who have recovered can be a rich source of antibodies, proteins made by the immune system to attack the virus. The part of the blood that contains antibodies, so-called convalescent plasma, has been used for decades to treat infectious diseases, including Ebola and influenza. In the absence of a cure or vaccine for the coronavirus, a group of scientists is searching for a fast solution in an unconventional place: The veins of people who have recovered. Starting in New York City...

 Open Access DOI:10.23937/2378-3672/1410043

Purine Nucleoside Phosphorylase Inhibitors as Novel Immuno- Oncology Agent and Vaccine Adjuvant

Shanta Bantia

Article Type: Original Article | First Published: April 06, 2020

Purine Nucleoside Phosphorylase (PNP) deficiency in humans causes lymphopenia and this provided the rationale for developing PNP inhibitors as immunosuppressive agents. However, careful re-evaluation of clinical history of PNP deficient patients and clinical experience with PNP inhibitors together with new experimental data suggest inhibition of PNP may have immune activating effects through elevation of guanosine and activation of various tolllike receptors (TLRs). This paper proposes a mechani...

 Open Access DOI:10.23937/2378-3672/1410044

Is There A Vaccine for Covid-19 and Are We Unaware of It?

Kazhal Mobaraki and Jamal Ahmadzadeh

Article Type: Letter to the Editor | First Published: April 20, 2020

Vaccine production and immunization of the susceptible population against novel coronavirus (COVID-19) is the most important public health strategy in controlling and preventing the spread of disease. Considering the absence of a vaccine for COVID-19, physicians have to treat symptomatically using potential antiviral drugs (e.g. Tadalafil, Atorvastatin, Telmisartan, Ribavirin, Dipyridamole, Chloroquine phosphate and so forth). In such circumstances, the main question may arise on how we can chan...

 Open Access DOI:10.23937/2378-3672/1410042

Effect of Lactobacillus Rhamnosus GG on the Number and Differentiation of T Lymphocytes in the Intestine of Early Weaned Piglets

Seria Masole Shonyela, Bo Fong, Wentao Yang, Guilian Yang and Chunfeng Wang

Article Type: Research Article | First Published: February 20, 2020

In recent years, with the rapid development of Chinas breeding industry, the weaning age of piglets is also in advance. The weaning time of piglets determines the number of piglets per year and the reproduction rate of sows. At the same time, the earlier weaning the piglets, the lower the production cost. However, early weaning of piglets will have a series of adverse effects on piglets. First of all, piglets will suffer from malnutrition due to early weaning, and their growth and development wi...

 Open Access DOI:10.23937/2378-3672/1410041

Simplified Neutrophil Isolation Protocol

Antonio Muniz-Buenrostro, Alma Y Arce-Mendoza, Edgar I Montes-Zapata, Rubi C Calderon- Melendez and Maricruz J Montelongo-Rodriguez

Article Type: Original Article | First Published: February 13, 2020

Neutrophils are the most abundant leukocytes in humans and among the first cells to arrive on the site of inflammatory immune response. Due to their key role in inflammation, neutrophil functions such as locomotion, cytokine production, phagocytosis, respiratory burst and release of extracellular traps are extensively studied. In the presentstudy, we present a simplified neutrophil isolation protocol which has excellent reproducibility and low cost. Taken together, our findings point to the fact...

 Open Access DOI:10.23937/2378-3672/1410040

Total Flavonoid Extract of Pseudocedrela kotschyi (Schweinf) Harms (Meliaceae) Inhibits the Pro-Inflammatory Function of Asthmatic Patients Neutrophils

Oumar Mahamat, Guessom K Oulianovie, Tume Christopher and Kamanyi Albert

Article Type: Research Article | First Published: February 12, 2020

Asthma is one of the most common chronic diseases worldwide affecting approximately 300 million individuals. Asthma or anaphylaxis are allergic diseases essentially characterized by eosinophilia and mast cells release histamine which is responsible for the production of IgE. Nevertheless, neutrophils are highly implicated and it is demonstrated in about 50% of asthma cases. Consecutive to bronchial allergen challenge for example, there is an influx of neutrophils in proximal and distal airways. ...

Volume 7
Issue 1