Open Access DOI:10.23937/2378-3672/1410056
Evaluation of Cross-Reactivity of Suidasia pontifica with Allergens Blo t 5 from the Blomia tropicalis Mite
Francisca das Chagas Sobral Silva, Daniel Vasconcelos R Silva, Anderson Bruno Matos, Andrea Medeiros Salgado and Maria Queiroz
Article Type: Original Research | First Published: November 30, 2020
The immunological cross-reactivity between different species of dust mites such as Suidasia pontifica and Blomia tropicalis is a factor that can favor an immunotherapeutic treatment, having so great clinical relevancy. However, the pretreatment of the raw extract can potentialize its response as in the cross-reactivity analysis. Therefore, this paper seeks to pre-treat the Suidasia pontifica extract in order to obtain protein fractions by the “salt out” method and then evaluate the presence ...
Open Access DOI:10.23937/2378-3672/1410054
Do Physiological Doses of Epinephrine May Act as Immunomodulator and Mediator between Immune and Colon Cancer Cells?
Hanna Bessler, PhD, Chiya Moshe Leibovitch, MD and Meir Djaldetti, MD
Article Type: Research Article | First Published: August 08, 2020
Epinephrine is one of the major hormones orchestrating numerous physiological responses of the organism exposed to acute or chronic stress. In those cases the plasma level of the hormone exceeds manifold the physiological values present in healthy resting individuals. Higher epinephrine concentrations affect the immune system and modulate macrophages immune responses. The purpose of the present work was to detect if physiological concentrations of epinephrine may alter the capacity of human peri...
Open Access DOI:10.23937/2378-3672/1410055
Thymalin as a Potential Alternative in the Treatment of Severe Acute Respiratory Infection Associated with SARSCoV- 2
Lukyanov Sergey A, Kuznik Boris I, Shapovalov Konstantin G, Khavinson Vladimir K, Smolyakov Yuri N, Tereshkov Pavel K, Shapovalov Yuri K, Konnov Valery A and Magen Eli
Article Type: Case Report | First Published: August 08, 2020
Polypeptide medication Thymalin obtained from the calf thymus has beneficial effects on cell-mediated immunity and blood coagulation. Here we present a patient with COVID- 19 severe pneumonia, who has first treated with Lopinavir/ Ritonavir + hydroxychloroquine without clinical benefit; and was then given Thymalin treatment with impressive clinical and laboratory improvement. Infection induced by a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2), causes acut...
Open Access DOI:10.23937/2378-3672/1410053
Durable and Effectiveness of Immunotherapy in the Treatment of Metastatic Gastroesophageal Junction Cancer
Carlos Gil Moreira Ferreira, MBBS, Gustavo Bittencourt Camilo, Eleusa Nogueira Dias, Bianca Lopes de Oliveira, Carlos Murilo Schanuel, Juliana Abreu de Vasconcellos and Emílio Campos Augusto Pereira de Assis
Article Type: Case Report | First Published: July 09, 2020
Gastroesophageal junction adenocarcinoma (AJEG) is a neoplasm that is globally prevalent with generally bad clinical outcome. It is estimated that there is an annual incidence of new tumors in the order of 572,034 in the US with about 28,000 new cases and 10,960 deaths attributable to the disease. In Brazil, an estimated 11390 new cases, corresponding to 8690 in men and 2077 in women for the year 2020. About half of the people with cancer of the esophagus or the gastroesophageal junction have me...