International Journal of

Medical Nano ResearchISSN: 2378-3664


 Open Access DOI:10.23937/2378-3664.1410026

Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Arpagaus Crpagaus

Article Type: Review Article | First Published: December 05, 2018

Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder part...

 Open Access DOI:10.23937/2378-3664/1410025

Folate Targeted Galactomannan Coated Iron Oxide Nanoparticles as a Nanocarrier for Targeted Drug Delivery of Capecitabine

Subha Veeramani, Kirubanandan Shanmugam and Renganathan Sahadevan

Article Type: Research Article | First Published: November 22, 2018

Iron oxide nanoparticle is the most promising nanoparticles (NPs) capable in Drug Delivery and targeting. Iron oxide nanoparticles were synthesized by green synthesis. Galactomannan, when attached to the surface of the nanoparticles, increases the biocompatibility of the nanoparticles. Folic acid (FA) is used as the ligand to target folate receptors, which are found abundant in cancer cells. FeNPs-GM-FA could target cancer cells when used as drug carriers. The synthesized iron oxide nanoparticle...

 Open Access DOI:10.23937/2378-3664.1410024

Silver Nanoparticles - Green Synthesis with Aq. Extract of Stems Ipomoea Pes-Caprae, Characterization, Antimicrobial and Anti-Cancer Potential

Subha Veeramani, Ernest Ravindran RS, Preethi Ramadoss, Cyrril Joseph, Kirubanandan Shanmugam and Renganathan S

Article Type: Research Article | First Published: October 10, 2018

Green synthesis is a novel process for the preparation of numerous metallic nanoparticle and provides a safer and eco-friendly process simultaneously achieving functionalization of nanoparticles with bioactive molecules in the plants extract. Green synthesis of silver nanoparticles (AgNPs) is performed using the aqueous extract of Ipomoea pes-caprae stems which acts as a bio-reducing agent. UV spectroscopic investigation confirms the formation of AgNPs by noticing the peak at 448 nm due to its s...

 Open Access DOI:10.23937/2378-3664/1410023

In Vitro Dissolution Studies on Naproxen-PVP Nanoformulations Show Enhanced Oral Bioavailability of Naproxen

Sandeep Patnaik, Aditya D Kurdekar, LA Avinash Chunduri, C Prathibha and K Venkataramaniah

Article Type: Research Article | First Published: October 08, 2018

Phase solubility behavior, physico-chemical characteristics, cytotoxicity, morphology and dissolution enhancement of Naproxen-PVP Nanoformulations have been studied. Drug-polymer ratios of 1:1, 1:2, 1:3, 1:4 for the poorly water-soluble drug, naproxen and the polymer PVP are prepared via wet milling using a conventional Retsch Planetary ball mill. The highest dissolution enhancement over that of the pure drug, 310% was achieved for the formulation ratio of 1:4. This ability of amphiphilic surfac...

 Open Access DOI:10.23937/2378-3664/1410022

Production of Electrochemiluminescence (ECL) Biosensor Using Os-Pd/HfC Nanocomposites for Detecting and Tracking of Human Gastroenterological Cancer Cells, Tissues and Tumors

Alireza Heidari

Article Type: Research Article | First Published: October 08, 2018

In the current paper, the first step for using Os-Pd/HfC nanocomposites as luminophore in producing Electrochemiluminescence (ECL) biosensor-namely increasing the sensitivity of biosensor through creating Os-Pd/HfC nanocomposites and using it instead of other nanocomposites for detecting and tracking of human gastroenterological cancer cells, tissues and tumors, is evaluated. Further, optimization of tri-n-propylamine (TPrA), 2-(dibutylamino) ethanol (DBAE) and benzyl peroxide (BPO) concentratio...

 Open Access DOI:10.23937/2378-3664/1410021

Aptamer-Conjugated Magnetic Bead Pull Down and Detection of Human Growth Hormone Releasing Peptides from Serum and Urine by Mass Spectrometry

John G Bruno and Taylor Phillips

Article Type: Research Article | First Published: April 30, 2018

DNA aptamers were developed against human growth hormone releasing peptide (GHRP)-6 and the major metabolite of GHRP-2 (pralmorelin) known as AA-3 (D-Ala-D(β-naphthyl)-Ala-Ala-OH) in 10% human serum or 50% human urine. The lead 5'-biotinylated candidate aptamers from ELISA-like microplate screening were conjugated to commercially available Dynal™ streptavidin-polystyrene-coated 2.8 µm diameter magnetic (magnetite) microbeads (MBs) and used to "pull down" and purify or enrich for their cognat...

Volume 5
Issue 1