International Journal of

Neurodegenerative DisordersISSN: 2643-4539


 Open Access DOI:10.23937/2643-4539/1710017

Immunomodulating, Neuroprotective and Regenerative Modalities in Multiple Sclerosis Management

Mike KS Chan, Michele Zocchi, Dina Tulina, Anam K Kour, Lau Cher Rene, Roni Moya and Michelle WB Fah

Article Type: Review Article | First Published: September 10, 2020

The phenomenon of “Westernization” in Asian countries which includes a specific choice of food and lifestyle was related to the higher prevalence of MS in Asia’s population which almost supports new findings on the great influence of gut and its microbiota in people worldwide. The current conventional therapy helps to prolong the periods between attacks and relapses, but in fact, does not slow down the disease progression and impact on physical activities which eventually leads to disabili...

 Open Access DOI:10.23937/2643-4539/1710016

The Broader Role of Basal Ganglia in the Semantic Aspect of Language: an Interesting Finding in the Neuropsychological Assessment of Huntington's Disease

Omid Mohamadi and Farhad Torabinezhad

Article Type: Case Report | First Published: June 01, 2020

The patient was a 64-year-old man with movement disorder and dysarthria, which was referred to the Speech Therapy Clinic of Hazrat Rasoul Hospital affiliated with Iran University of Medical Sciences. The level of education of the patient was PhD in political science and his job was to teach part-time at the university as well as high school management. The onset of obvious symptoms in this patient dates back to about 4 years and 7 months ago. At that time, he was not able to keep the names of hi...

 Open Access DOI:10.23937/2643-4539/1710015

A Benchmark Study on the Correlation of CAG Trinucleotide Repeat Length with SARA Score, Age of Onset and Disease Duration of Genetically-positive Spinocerebellar Ataxia 2 Filipino Family

Jessica Leika R Matibag, MD , Eri Uematsu, MD, and Cid Czarina Diesta, MD, FPNA

Article Type: Original Researc h | First Published: April 11, 2020

Spinocerebellar ataxia 2 is a rare neurodegenerative disease characterized by a complex neurological presentation of ataxia of adult onset with an autosomal dominant inheritance caused by an abnormal expansion of trinucleotide CAG repeat. The aim of this study is to determine the correlation of CAG trinucleotide repeat length with Scale for assessment and rating of ataxia score, age of onset and disease duration among genetically-positive individuals....

 Open Access DOI:10.23937/2643-4539/1710014

Predictors of Health-Related Quality of Life and Communicative Participation in Individuals with Dysarthria from Parkinson’s Disease

Kristie A Spencer, Clare Friedlander and Katherine A Brown

Article Type: Researc h Article | First Published: January 03, 2020

The motor and non-motor deficits of Parkinson’s disease (PD) can cause daily challenges and have been associated with reduced health-related quality of life (HrQoL). A number of variables have been consistently, though not unequivocally, identified as important in influencing overall HrQoL in individuals with PD, such as demographic factors, cognitive decline, and level of motor impairment. However, the presence and severity of dysarthria is often overlooked, despite the potentially adverse in...

Volume 3
Issue 1