International Journal of

Neurology and NeurotherapyISSN: 2378-3001


 Open Access DOI:10.23937/2378-3001/2/2/1035

Severe Bradycardia after Topical Use of Papaverine during a Pons Cavernoma Surgery

Demian Manzano Lopez Gonzalez, Gerardo Conesa Bertran and Jesus Lafuente Baraza

Article Type: Case Report | First Published: November 05, 2015

Papaverine is a potent smooth muscle relaxant and has vasodilator properties. Topical use of papaverine is widely accepted in neurosurgery to prevent cerebral vasospasm. Growing evidence supports that papaverine may have a neural toxicity effect. We present a case of a 15 years-old patient that was operated on hemorrhagic cavernoma in the floor of the fourth ventricle. A transvermian approach was performed and neurophysiological monitoring was set up. During surgery, the motor evoked potentials ...

 Open Access DOI:10.23937/2378-3001/2/2/1034

Association between the ERCC1 Polymorphisms and Glioma Risk: A Meta-Analysis of Case-Control Studies

Liu Yan, Cai Xiao Qin, Zhao Lian Ying, Shen Heng Shan, Hu Jian Wei

Article Type: Original Research Article | First Published: October 13, 2015

Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Published data regarding the association between excision repair cross-complementing rodent repair deficiency complementation group1 (ERCC1) polymorphisms and glioma risk have been inconsistent and inconclusive. To acquire a more precise effect of the association between these polymorphisms and glioma risk, a meta-analysis was performed....

 Open Access DOI:10.23937/2378-3001/2/2/1033

Cognitive Impairment and the Diabetic Brain

Kurt A Jellinger

Article Type: Mini Review | First Published: October 12, 2015

Alzheimer's disease (AD) and diabetes mellitus (DM) are the two most common and devastating health problems in the elderly. DM is a known risk factor for the development of cognitive dysfunction and dementia. Epidemiological and biological evidences support a link between type 2 DM (T2DM) and AD, but the precise mechanisms involved in the development of cognitive impairment in diabetics are not fully understood. Possible pathogenic pathways include genetic factors, ageing, ApoE status, hypo- and...

 Open Access DOI:10.23937/2378-3001/2/2/1032

Citicoline Treatment Improves Measures of Impulsivity and Task Performance in Chronic Marijuana Smokers: A Pilot BOLD fMRI Study

Staci A. Gruber, Kelly A. Sagar, Mary Kathryn Dahlgren, Atilla Gonenc, Nina A. Conn, Jeffrey P. Winer, David Penetar and Scott E. Lukas

Article Type: Original Research Article | First Published: September 10, 2015

Citicoline is an endogenous nucleotide that has historically been used to treat stroke, traumatic brain injury, and cognitive dysfunction. Research has also shown that citicoline treatment is associated with improved cognitive performance in substance-abusing populations. We hypothesized that marijuana (MJ) smokers who received citicoline would demonstrate improvement in cognitive performance as well as increased neural efficiency during tasks of cognitive control relative to those who received ...

 Open Access DOI:10.23937/2378-3001/2/2/1031

Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?

Troy T. Rohn

Article Type: Review Article | First Published: August 28, 2015

The presence of corpora amylacea (CA) in the CNS is associated with both normal aging and neurodegenerative conditions including Alzheimer's disease (AD) and vascular dementia (VaD). CA are spherical bodies ranging in diameter (10-50 micro meter) and whose origin has been documented to be derived from both neural and glial sources. CA are reported to be primarily composed of glucose polymers, but approximately 4% of the total weight of CA is consistently composed of protein. CA are typically loc...

 Open Access DOI:10.23937/2378-3001/2/2/1030

Acute Treatment with Renal Denervation in a Patient with Resistant Hypertension and Hemorrhagic Stroke

Francesco Versaci, Antonio Trivisonno, Luca Brunese and Francesco Prati

Article Type: Case Report | First Published: August 28, 2015

A 49-year-old man with refractory hypertension was admitted to our hospital in a coma caused by hemorrhagic stroke. Severe hypertension was observed during hospitalization despite a full antihypertensive therapy. Considering the risk of enlargement of the intracranial hematoma, the decision was made to perform renal denervation (RDN). A significant blood pressure reduction was obtained after RDN. The patient had a progressive improvement of general conditions and came out of the coma after a few...

 Open Access DOI:10.23937/2378-3001/2/2/1029

Clock Drawing Test (CDT): is Qualitative Analysis of the CDT Better to Screen Mild Cognitive Impairment than Quantitative Analysis?

Ji Hee Lee, Eung Seok Oh, Eun Hee Sohn and Ae Young Lee

Article Type: Original Article | First Published: July 06, 2015

Mild cognitive impairment (MCI) was originally used to describe a transitional state between normal condition and dementia. Revised and extended definition of MCI has been proposed that covers a broader range of cognitive impairment, distinct from normal ageing and from Alzheimer's disease. Despite the existence of reports regarding analyses of the Clock Drawing test (CDT) in Alzheimer's disease and vascular dementia, those focusing on MCI subjects are still lacking. The purpose of this study wa...

Volume 2
Issue 2