Severe Bradycardia after Topical Use of Papaverine during a Pons Cavernoma Surgery
Demian Manzano Lopez Gonzalez, Gerardo Conesa Bertran and Jesus Lafuente Baraza
Article Type: Case Report | First Published: November 05, 2015
Papaverine is a potent smooth muscle relaxant and has vasodilator properties. Topical use of papaverine is widely accepted in neurosurgery to prevent cerebral vasospasm. Growing evidence supports that papaverine may have a neural toxicity effect. We present a case of a 15 years-old patient that was operated on hemorrhagic cavernoma in the floor of the fourth ventricle. A transvermian approach was performed and neurophysiological monitoring was set up. During surgery, the motor evoked potentials ...
Association between the ERCC1 Polymorphisms and Glioma Risk: A Meta-Analysis of Case-Control Studies
Liu Yan, Cai Xiao Qin, Zhao Lian Ying, Shen Heng Shan, Hu Jian Wei
Article Type: Original Research Article | First Published: October 13, 2015
Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Published data regarding the association between excision repair cross-complementing rodent repair deficiency complementation group1 (ERCC1) polymorphisms and glioma risk have been inconsistent and inconclusive. To acquire a more precise effect of the association between these polymorphisms and glioma risk, a meta-analysis was performed....
Cognitive Impairment and the Diabetic Brain
Kurt A Jellinger
Article Type: Mini Review | First Published: October 12, 2015
Alzheimer's disease (AD) and diabetes mellitus (DM) are the two most common and devastating health problems in the elderly. DM is a known risk factor for the development of cognitive dysfunction and dementia. Epidemiological and biological evidences support a link between type 2 DM (T2DM) and AD, but the precise mechanisms involved in the development of cognitive impairment in diabetics are not fully understood. Possible pathogenic pathways include genetic factors, ageing, ApoE status, hypo- and...
Citicoline Treatment Improves Measures of Impulsivity and Task Performance in Chronic Marijuana Smokers: A Pilot BOLD fMRI Study
Staci A. Gruber, Kelly A. Sagar, Mary Kathryn Dahlgren, Atilla Gonenc, Nina A. Conn, Jeffrey P. Winer, David Penetar and Scott E. Lukas
Article Type: Original Research Article | First Published: September 10, 2015
Citicoline is an endogenous nucleotide that has historically been used to treat stroke, traumatic brain injury, and cognitive dysfunction. Research has also shown that citicoline treatment is associated with improved cognitive performance in substance-abusing populations. We hypothesized that marijuana (MJ) smokers who received citicoline would demonstrate improvement in cognitive performance as well as increased neural efficiency during tasks of cognitive control relative to those who received ...
Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?
Troy T. Rohn
Article Type: Review Article | First Published: August 28, 2015
The presence of corpora amylacea (CA) in the CNS is associated with both normal aging and neurodegenerative conditions including Alzheimer's disease (AD) and vascular dementia (VaD). CA are spherical bodies ranging in diameter (10-50 micro meter) and whose origin has been documented to be derived from both neural and glial sources. CA are reported to be primarily composed of glucose polymers, but approximately 4% of the total weight of CA is consistently composed of protein. CA are typically loc...
Acute Treatment with Renal Denervation in a Patient with Resistant Hypertension and Hemorrhagic Stroke
Francesco Versaci, Antonio Trivisonno, Luca Brunese and Francesco Prati
Article Type: Case Report | First Published: August 28, 2015
A 49-year-old man with refractory hypertension was admitted to our hospital in a coma caused by hemorrhagic stroke. Severe hypertension was observed during hospitalization despite a full antihypertensive therapy. Considering the risk of enlargement of the intracranial hematoma, the decision was made to perform renal denervation (RDN). A significant blood pressure reduction was obtained after RDN. The patient had a progressive improvement of general conditions and came out of the coma after a few...