International Journal of

Neurology and NeurotherapyISSN: 2378-3001

Archive

 Open Access DOI:10.23937/2378-3001/3/2/1047

In Dubio Pro Therapia: Unexpected Recovery after Palliative Endoscopic Third Ventriculostomy and Temozolomide Chemotherapy in a Patient with Progressive Glioblastoma multiforme

Anne-Katrin Hickmann, Daniel Kirschenbaum, Lucas Widmer, MarcinSumila, Stephan Wetzel and Robert Reisch

Article Type: Case Report | First Published: April 18, 2016

A 38-year-old female with a 7-year history of recurrent high-grade astrocytoma was admitted to our institution presenting with progressive signs of increased intracranial pressure. MRI showed widespread tumor recurrence with diffuse infiltration of the ventricular walls, basal cisterns and concomitant hydrocephalus. After careful consideration a palliative endoscopic third ventriculostomy was performed. After surgery the patient's condition improved significantly. Thus far she had only undergone...

 Open Access DOI:10.23937/2378-3001/3/2/1046

Multiple System Atrophy: Moving towards a Multi-mechanistic Hypothesis

Monica Federoff

Article Type: Commentary | First Published: April 09, 2016

With an estimated incidence of 3-4 per every 100,000 individuals among adults 50-99 years of age, Multiple System Atrophy (MSA) is a rare progressive neurodegenerative disease clinically characterized by the following trio: cerebellar ataxia, parkinsonism and autonomic dysfunction in conjunction with pyramidal signs. MSA usually progresses over a 7-9 year period, with an average age of onset of 57 and affects both sexes equally....

 Open Access DOI:10.23937/2378-3001/3/2/1045

Anterior Junction Syndrome Caused by Neuromyelitis Optica

Ma Eugenia Garcia Garcia, Javier Casas Limon, Aida Orviz Garcia and Alberto Marcos Dolado

Article Type: Case Report | First Published: April 08, 2016

The anterior junction syndrome is a specific manifestation caused by optic nerve involvement at the junction with the optic chiasm and the contralateral inferonasal nerve fibers (Wilbrand's Knee). Lesions at this point show a specific pattern of visual impairment which is characterized by an advanced monocular visual field loss, together with circumscribed visual field defects, respecting the vertical midline in the other eye (junctional scotoma). Although pituitary adenomas are the most frequen...

 Open Access DOI:10.23937/2378-3001/3/2/1044

Trigeminal Neuropathy as a Relapse in Behcet Disease

Goncalo Cacao, Isabel Moreira, Jose Eduardo Alves, Fatima Farinha and Ernestina Santos

Article Type: Case Report | First Published: March 29, 2016

A 49 years old woman, diagnosed with Neuro-Behcet, was admitted with complains of numbness, aching and periods of electric shock-like pain in right side of the face. Associated with painful oral ulcers, anorexia, nausea and gait instability. Neurological examination revealed dysesthesia on right trigeminal nerve territory, horizontal-rotatory nistagmus on horizontal gaze bilateral with fast phase to the right and tandem instability. Brain MRI revealed new lesions. It was assumed a rhombencephali...

 Open Access DOI:10.23937/2378-3001/3/2/1043

Neuromyelitis Optica Spectrum Disorder in A Ninety-year-old Woman. A Case Report

Romero-Delgado Fernando, Cuello Juan-Pablo, Garcia-Dominguez Jose-Manuel, Higueras-Hernandez Yolanda, Goicochea-Briceno Haydee, Guzman-de-Villoria Juan Adan and Martinez-Gines Maria-Luisa

Article Type: Case Report | First Published: March 28, 2016

Neuromyelitis Optica (NMO) is an inflammatory demyelinating, necrotizing disease of the central nervous system, with a predilection for the optic nerves and spinal cord. Clinical, radiological and immunopathological characteristics distinguish it from multiple sclerosis (MS). Recently, new diagnostic criteria have been published, and the terms NMO and neuromyelitis optica spectrum disorder (NMOSD) have been unified, allowing a diagnosis of NMOSD on clinical grounds or on anti-AQP4 antibody statu...

 Open Access DOI:10.23937/2378-3001/3/2/1042

MR-Guided Laser Interstitial Thermal Therapy for the Treatment of Medically Refractory Epilepsy

Shasha Wu, James X. Tao, Naoum P. Issa, Sandra Rose and Peter Warnke

Article Type: Review Article | First Published: March 02, 2016

Resective epilepsy surgery is highly effective in the treatment of medically refractory epilepsy. However, it involves an open craniotomy and carries the risks of permanent functional deficits and cosmetic concerns. Multiple minimally invasive surgical approaches have been attempted to destroy seizure foci with minimal damage to surrounding normal tissue. Here we review the currently available minimally invasive surgical approaches for epilepsy, with an emphasis on MR-guided laser interstitial t...

Volume 3
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