Cerebral Hemodynamics in Patients with Rheumatoid Arthritis
Uygar Utku and Muhammed Nur OGUN
Article Type: Original Article | First Published: December 15, 2018
A total of 22 patients aged 20 to 40-years-old with RA were enrolled in the RA group consecutively. Control group (non-RA group) consisted of 22 age and sex-matched, randomly selected patients without RA who had other diagnosis such as fibromyalgia and did not have risk factors for atherosclerosis (AS). Bilateral middle cerebral artery (MCA) peak-systolic, end-diastolic, and mean blood flow velocities, Pourcelot's resistance index values and Gosling's pulsatility index values were recorded with ...
Cerebral Histoplasmosis in Non-Immunosuppressed Patient - Case Report
Andre Eduardo de Almeida FRANZOI, Nayme Hechem MONFREDINI, Leonora Zozula Blind POPE, Felipe Ibiapina dos REIS and Fabio Antonio TIRONI
Article Type: Case Report | First Published: October 12, 2018
Histoplasmosis is a disease caused by Histoplasma capsulatum var. capsulatum, which is endemic in Latin America. The manifestation of the disease in the central nervous system (CNS) is more frequent in immunosuppressed individuals with disseminated presentation. Pulmonary manifestations are usually the first symptoms. However, when neurological manifestations are the first clinical manifestations, the diagnosis becomes a challenge. The early diagnosis is fundamental in the final outcome of the p...
Dementia with Lewy Bodies and Parkinson's Disease-Dementia: Current Perspectives
Kurt A Jellinger
Article Type: Review Article | First Published: October 12, 2018
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD) are two closely related major neurocognitive disorders with Lewy bodies of unknown etiology, showing notable overlap in their clinical presentation, pathological features, biochemistry, and genetic risk factors. According to international consensus, their diagnosis is based on an arbitrary distinction between the time of onset of motor and cognitive symptoms: dementia preceding parkinsonism in DLB, while it develops after ons...
Olfactory Dysfunction: A Potentially Negative Sign for Depression
Zhengwei Wen, Hua-Zhen Lin, Yao-Yao Li and Yun-Feng Zhang
Article Type: Mini Review | First Published: August 11, 2018
Depression is a typical neuropsychiatric disorder and has led to great economic and social burden worldwide. During the past few decades, though great efforts have been made on parsing out this mental disease, the potential association of olfactory dysfunctions with depression still remains much to be characterized. Here in this short review, we concisely summarized the evidence of how olfactory dysfunctions acting as a negative marker potentially sign the depression....