A Novel Automated Algorithm Effectively Titrates Stimulation in an Implantable Vagus Nerve Stimulation Device
Imad Libbus, PhD, Enea Dede, MD, Scott Stubbs, BSEE, Lorenzo DiCarlo, MD, Scott Mazar, MSEE, Badri Amurthur, MSEE MBA and Bruce H KenKnight, PhD
Article Type: Brief Report | First Published: November 11, 2020
Autonomic Regulation Therapy (ART) using chronic Vagus Nerve Stimulation (VNS) is in development for patients with heart failure who remain symptomatic despite standard care. In the ANTHEM-HF Pilot Study, a therapeutic VNS intensity was successfully achieved in patients with HFrEF using manually programmed VNS up-titration. An algorithm has been developed for automatically intensifying VNS in small increments to a programmable target intensity, and capable of adjustments during the up-titration ...
CANOMAD: A Multi-Faceted Disease
Júlia Machado Rickli, Gabriela Pomaleski and Marcus Vinícius Magno Gonçalves, MD PhD
Article Type: Non-Systematic Review | First Published: October 30, 2020
CANOMAD is a rare syndrome that belongs to the group of peripheral neuropathies associated with IgM monoclonal gammopathy. This acronym was first used in 1996 to describe the clinical features of the disease, which include: Chronic sensory ataxic neuropathy, ophtalmoplegia, M-protein with cold-agglutinin activity and anti-disialosyl antibodies. The syndrome’s physiopathology is not fully understood, but, according to the available researches, it will be expressed in patients whose serum contai...
What is the Real Impact of SARS-CoV-2 on Stroke: Do We More Have to Learn?
Luiz Severo Bem Junior, Luís Felipe Gonçalves de Lima, Júlio Cesár Tavares Marques, Pedro Lukas do Rêgo Aquino, Andrey Maia Silva Diniz, Artêmio José Araruna Dias, Flávio Monteiro de Oliveira Júnior, Nicollas Nunes Rabelo, Hildo Rocha Cirne de Azevedo Filho
Article Type: Systematic Review | First Published: September 09, 2020
Coronaviruses (CoV) is virus infectious disease witch a considerable spectrum of clinical presentation. Neurologic symptoms related to SARS-CoV-2 have been described recently in the literature. Among a wide variety of neurological symptoms, acute cerebrovascular disease is one of the most serious complications. This review aimed to reveal the current knowledge regarding stroke in new coronavirus infection as way to improve its diagnosis and treatments. A systematic literature review was carried ...
Mononeuritis Multiplex Associated with Sars-Cov2-Covid-19 Infection: Case Report
Enrique Estévez-Rivera, MD, Javier Benavides-Hinestroza, MD, Hernando Rubiano, MD, Herney Andrés García-Perdomo, MD
Article Type: Case Report | First Published: September 09, 2020
We present the case of a 63-year-old female patient from Ipiales (Nariño, Colombia) with COVID-19 Pneumonia (positive PCR test on April 9, 2020, repeated on April 29, 2020, confirming the diagnosis). He was hospitalized in the ICU for 50 days and required prolonged mechanical ventilation. Significant pathological history: Hypertension and hypothyroidism. During her ICU hospitalization, she had kidney failure that required several dialysis sessions. Simultaneously, she showed persistent febrile ...
Migraines and CGRP Monoclonal Antibodies: A Review of Cardiovascular Side Effects and Safety Profile
Kimberly Boldig, MMS and Nitin Butala, MD
Article Type: Review Article | First Published: July 31, 2020
Migraine headaches are a very common complaint described by patients and few medications have been designed solely for their treatment. Current knowledge of migraine pathogenesis relates to various neuropeptides, including calcitonin gene related peptide (CGRP), acting on blood vessels within the brain and causing vasodilation. Sensory fibers detect this change and it is perceived as pain. This understanding has led to the development of CGRP monoclonal antibodies as possible migraine treatment....