Open Access DOI:10.23937/2378-346X/1410033
Inflammation and Oxidative Stress in Retinal Diseases: The Role of Intracellular Signaling in the Retinal Pigment Epithelium
Melina V. Mateos, Paula E. Tenconi, Norma M. Giusto and Gabriela A. Salvador
Article Type: Review Article | First Published: August 23, 2015
Inflammation and oxidative stress (OS) are common factors involved in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Most of the studies on the above mentioned diseases have been focused on the neural retina. However, in view of the importance of the retinal pigment epithelium (RPE) in the maintenance of photoreceptors' (PR) viability and vi...
Open Access DOI:10.23937/2378-346X/1410032
Surgical Management of Concomitant Ptosis and Cicatricial Entropion in a Patient with Ocular Cicatricial Pemphigoid
Scuderi G, Mutolo MG, Lambiase A and Recupero SM
Article Type: Case Report | First Published: August 22, 2015
A 71 year-old patient presented with vision impairment and pain in the right eye due to entropion associated with trichiasis and mild-ptosis. He had a history of ocular cicatricial pemphigoid together with a lung cancer of the apex of the right lung with pleural involvement. There was a history of central retinal vein occlusion of the left eye. Clinical and orthoptic examination was conducted and a decision was made to perform surgical correction of the entropion followed by correction of ptosis...
Open Access DOI:10.23937/2378-346X/1410030
Retinitis Pigmentosa: Disease Encumbrance in the Eurozone
Vaidya P and Vaidya A
Article Type: Research Article | First Published: July 28, 2015
Retinitis Pigmentosa (RP) is the most common hereditary progressive retinal degenerations and is fist cause of irreversible blindness in developed countries among persons under 70 years of age. It is characterised by progressive degeneration of the retinal photoreceptors. The objective of this review was to determine the burden of RP in the Eurozone....
Open Access DOI:10.23937/2378-346X/1410029
Treatment of a Pseudoxanthoma Elasticum Patient Initially Presented with Choroidal Neovascularisation Secondary to Angioid Streaks
Muhammed Sahin, Alparslan Sahin, Harun Yuksel, Umit Peker and Fatih Mehmet Turkcu
Article Type: Case Report | First Published: July 20, 2015
Pseudoxanthoma elasticum (PXE) is a rare, systemic disease with typical ophthalmological findings including angioid streaks (AS) (represent breaks in the Bruch's membrane). A serious and common complication of AS is the development of choroidal neovascularization (CNV), which can result in significant and irreversible vision loss. The introduction of intravitreal agents that inhibit vascular endothelial growth factor (VEGF) has improved outcomes in patients with CNV. In this paper we aimed to pr...
Open Access DOI:10.23937/2378-346X/1410028
Acute Ophthalmic Artery Occlusion as Initial Manifestation of Acquired Immunodeficiency Syndrome
Gowtham Jonna, Matthew SJ Katz, David M Rubaltelli, David C Gritz and Peter L Gehlbach
Article Type: Case Report | First Published: July 20, 2015
Purpose: To report the first case of acute ophthalmic artery occlusion as initial manifestation of Acquired Immunodeficiency Syndrome (AIDS) in context of marked Human Immunodeficiency Virus-1 (HIV-1) viremia and otherwise negative work-up. Methods: Report of a 25 year-old previously healthy man who presented to a hospital-based tertiary care referral center with acute, monocular vision loss. Complete ophthalmologic examination, fluorescein angiography, and full systemic evaluation were performe...