International Journal of

Ophthalmology and Clinical ResearchISSN: 2378-346X

Archive

 Open Access DOI:10.23937/2378-346X/1410034

Retrospective Comparison of Scleral Flap and Scleral Burial Techniques to Fixate A Scleral Sutured Intraocular Lens Concurrently with Penetrating Keratoplasty

Bora Yuksel, Alper Gulucu, Umut Duygu Uzunel and Tuncay Kusbeci

Article Type: Research Article | First Published: August 25, 2015

Definitive surgical treatment of aphakia in the presence of corneal opacity is secondary intraocular lens (IOL) implantation combined with penetrating keratoplasty (PK). The two main locations for IOL implantation are in the anterior chamber (ACIOL) and in the posterior chamber (PCIOL). Insertion of PCIOLs can be performed by capsular-supported, iris-supported, or transsclerally sutured PCIOL. Each technique has strengths and weaknesses with respect to surgical difficulty, operative time, and co...

 Open Access DOI:10.23937/2378-346X/1410033

Inflammation and Oxidative Stress in Retinal Diseases: The Role of Intracellular Signaling in the Retinal Pigment Epithelium

Melina V. Mateos, Paula E. Tenconi, Norma M. Giusto and Gabriela A. Salvador

Article Type: Review Article | First Published: August 23, 2015

Inflammation and oxidative stress (OS) are common factors involved in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Most of the studies on the above mentioned diseases have been focused on the neural retina. However, in view of the importance of the retinal pigment epithelium (RPE) in the maintenance of photoreceptors' (PR) viability and vi...

 Open Access DOI:10.23937/2378-346X/1410032

Surgical Management of Concomitant Ptosis and Cicatricial Entropion in a Patient with Ocular Cicatricial Pemphigoid

Scuderi G, Mutolo MG, Lambiase A and Recupero SM

Article Type: Case Report | First Published: August 22, 2015

A 71 year-old patient presented with vision impairment and pain in the right eye due to entropion associated with trichiasis and mild-ptosis. He had a history of ocular cicatricial pemphigoid together with a lung cancer of the apex of the right lung with pleural involvement. There was a history of central retinal vein occlusion of the left eye. Clinical and orthoptic examination was conducted and a decision was made to perform surgical correction of the entropion followed by correction of ptosis...

 Open Access DOI:10.23937/2378-346X/1410031

Ocular Hypotensive Activity of a Non-Peptide Bradykinin B2-Receptor Antagonist (WIN-64338) In Dutch-Belt Rabbits- A Case of Poly-Pharmacology in Action

Najam A Sharif, Laura Klekar, Linya Li and Shouxi Xu

Article Type: Research Article | First Published: August 11, 2015

Ocular hypertension is a well-recognized and treatable biomarker that is believed to be involved in the etiology of primary open-angle glaucoma, the second leading cause of blindness in the world. This retinopathy is a painless disease that is slow but progressive and steals the patient's sight if left untreated. Over the last several decades, a number of pharmaceutical agents have been shown to be effective in reducing intraocular pressure (IOP) and have been approved for treatment of glaucoma ...

 Open Access DOI:10.23937/2378-346X/1410030

Retinitis Pigmentosa: Disease Encumbrance in the Eurozone

Vaidya P and Vaidya A

Article Type: Research Article | First Published: July 28, 2015

Retinitis Pigmentosa (RP) is the most common hereditary progressive retinal degenerations and is fist cause of irreversible blindness in developed countries among persons under 70 years of age. It is characterised by progressive degeneration of the retinal photoreceptors. The objective of this review was to determine the burden of RP in the Eurozone....

 Open Access DOI:10.23937/2378-346X/1410029

Treatment of a Pseudoxanthoma Elasticum Patient Initially Presented with Choroidal Neovascularisation Secondary to Angioid Streaks

Muhammed Sahin, Alparslan Sahin, Harun Yuksel, Umit Peker and Fatih Mehmet Turkcu

Article Type: Case Report | First Published: July 20, 2015

Pseudoxanthoma elasticum (PXE) is a rare, systemic disease with typical ophthalmological findings including angioid streaks (AS) (represent breaks in the Bruch's membrane). A serious and common complication of AS is the development of choroidal neovascularization (CNV), which can result in significant and irreversible vision loss. The introduction of intravitreal agents that inhibit vascular endothelial growth factor (VEGF) has improved outcomes in patients with CNV. In this paper we aimed to pr...

 Open Access DOI:10.23937/2378-346X/1410028

Acute Ophthalmic Artery Occlusion as Initial Manifestation of Acquired Immunodeficiency Syndrome

Gowtham Jonna, Matthew SJ Katz, David M Rubaltelli, David C Gritz and Peter L Gehlbach

Article Type: Case Report | First Published: July 20, 2015

Purpose: To report the first case of acute ophthalmic artery occlusion as initial manifestation of Acquired Immunodeficiency Syndrome (AIDS) in context of marked Human Immunodeficiency Virus-1 (HIV-1) viremia and otherwise negative work-up. Methods: Report of a 25 year-old previously healthy man who presented to a hospital-based tertiary care referral center with acute, monocular vision loss. Complete ophthalmologic examination, fluorescein angiography, and full systemic evaluation were performe...

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