Surgery of Oncologic Surgical Pathologies during the COVID-19 Pandemic: The Ordeal of the Oncologic Patient
María Mercedes de la Torre-Bustamante, Juan Felipe Casabon-Pastrana, Diego Alejandro Largo- Cordoba, Diego Armando Gomajoa-Guerrero and Michael Gregorio Ortega-Sierra
Article Type: Editorial | First Published: March 24, 2022
The COVID-19 pandemic has been one of the worst global public health crises of the 21st century. Global health was strongly affected by the dynamics of nations in the face of measures to contain the SARS-Cov-2 infection, such as confinement and redistribution of resources, which delayed the diagnosis and treatment of a large number of diseases, negatively modifying the prognosis and quality of life of these patients. The burden of surgical and oncological diseases is currently very high, and its...
Prognostic Value of the Ki67 Proliferation Index, CD10 and MUM1 in Follicular Lymphoma
Minh Phuong Vu, Thanh Vui Le and Van Oanh Kieu
Article Type: Original Article | First Published: March 24, 2022
Follicular lymphoma (FL) is an indolent lymphoma and is associated with a long survival time. However, there are patients who had an early progression after standard therapy. Our aim was to analyze the prognostic value of Ki67, CD10 and MUM1 expression in FL. Immunohistochemical staining for Ki67, CD10 and MUM1 was performed on formalin-fixed paraffinembedded biopsy tissues from 27 patients with FL. Patients were grouped according to the levels of the Ki67 proliferation index (PI). Survival time...
Impacts of Genetic Polymorphisms on Breast Cancer
Hafez Ahmed and Mohamed Hussein
Article Type: Review Article | First Published: March 16, 2022
Breast cancer (BC), a malignant proliferation of the epithelial cells that line the ducts or lobules of the breast, is the most common malignancy in women, accounting for approximately one-third of all cancers in women worldwide. According to its death rate, it is the second most frequent cancer causing mortality for women worldwide. Polymorphism involves one of two or more variants of a particular DNA sequence. The most common type of polymorphism involves variation at a single base pair. In re...
Cell Proliferation, Contact Inhibition, and Apoptosis Profiling in a Benign and Malignant Breast Lesion
Olakayode V Ekundina, Chiamaka C Ejelue, Ondokeyi P Apulu and Ore-oluwa O Ayodele
Article Type: Original Article | First Published: January 29, 2022
Monitoring and diagnosis of benign or premalignant breast lesions as it progresses to a malignant condition is very necessary for its ability to predict or curb the progression of a breast lesion to the malignant condition and Immunohistochemistry has been proven to be a useful tool in achieving this as immunohistochemical markers are corresponding and specific in nature. The primary objective of this case-control study is to study the expression of KI67, E-cadherin, and P53 in normal breast tis...
Bladder Neuroendocrine Carcinoma: About Five Cases and Review of the Literature
Maryam Zaouit, Farida Marnissi, Hassan Jouhadi, Nadia Benchekroun, Asma Elkbir, Souha Sahraoui and Abdellatif Benider
Article Type: Case series | First Published: February 07, 2022
This is a retrospective descriptive study of five cases of neuroendocrine carcinoma of the bladder collected at the Mohammed VI Center, between January 2017 and December 2020. The diagnosis was confirmed by immunohistochemical study. The median age is 61 years (extremes: 36-73 years), all patients are male. The average delay of consultation is 7 months (extremes: 2-12 months). Chronic smoking was found in three patients. Hematuria was the cardinal sign in 4 cases. Irritative urinary disorders su...
Relationship between Awareness of Healthy Lifestyle and Perception of Breast Cancer among Women of Reproductive Age
Yeliz VARIŞOĞLU, PhD and Pınar IRMAK VURAL, PhD
Article Type: Original Article | First Published: January 31, 2022
The aim of this study was to determine the relationship between awareness of healthy lifestyle and breast cancer perception among women of reproductive age. This descriptive co relational study was conducted on 642 women. Data were collected using the sociodemographic data form, the Healthy Lifestyle Awareness Scale (HLAS), and the Breast Cancer Perception Scale (BCPS). A moderate, significant, and positive correlation was found between the HLAS total score and the scores obtained from the BCPS ...
Prognostic Utility of Targeted Circulating Cell-Free DNA versus Formalin-Fixed Paraffin-Embedded DNA Mutation Analysis for Advanced Lung Cancer
Madli Tamm, Mart Kals, Tarmo Annilo, Kersti Oselin, Katrin Keerma, Paula Ann Kivistik, Miriam Nurm, Margot Saare, Jana Jaal and Neeme Tõnisson
Article Type: Original Article | First Published: January 23, 2022
Cancer burden is a globally growing problem. Early diagnosis and targeted treatment decrease patients’ death rate, pain, and treatment expenses. Liquid biopsy can be used for early cancer detection, treatment selection, and progression and treatment response monitoring. We evaluated the performance of circulating cell-free DNA (cfDNA) and formalin-fixed paraffin-embedded (FFPE) tissue DNA analyses using a commonly employed targeted therapeutic pathway in predicting the outcomes of patients wit...