Bone Marrow Necrosis and Fat Embolism in a Patient with Sickle Cell Crisis, a Fatal Complication
Gagandeep Kaur, Oluwaseyi Olayinka and Gunjan Gupta
Article Type: Case Report | First Published: November 22, 2019
Sickle cell disease is a group of inherited disorder due to substitution of valine for glutamic acid at position 6 of beta globin chain of hemoglobin leading to sickling of red blood cells. It is most common in African ancestry. The sickled RBC’s can cause vaso-occlusive crisis leading to dreadful complications. We report a case of a 56-year-old female with past medical history of sickle cell disease, atrial fibrillation and prior history of stroke. She presented to the emergency department wi...
Widespread Multi-Organ Involvement by Lymphoplasmacytic B-Cell Lymphoma in a Patient with Multiple Comorbidities: A Case Report
Oluwaseyi Olayinka, Gagandeep Kaur, Nusrat Pathan and Paul Fiedler
Article Type: Case Report | First Published: October 31, 2019
Lymphoplasmacytic lymphoma (LPL) is an uncommon B-cell non-Hodgkin lymphoma in which the affected tissue, usually bone marrow, is infiltrated by small lymphocytes, plasmacytoid lymphocytes, and plasma cells. The lymph nodes, spleen and other tissues/organs in the body are less commonly infiltrated by the neoplastic cells. The clinical course of LPL is indolent although some studies report a more aggressive course and adverse outcomes especially in patients with other primary malignancies includi...
Mathematical Hegselmann-Krause (HK) Model Predicts Chemotherapeutic Resistance to Cisplatin in Human Cervical Cancer Cell Lines
John Zihou Chen, Rong Wu, Henry Simpkins, Zhendong Sun and Jianli Chen
Article Type: Original Research Article | First Published: September 25, 2019
Solid tumors usually have a complex cellular components and intercellular interactions in a complex tumor microenvironment. We used a mathematical HK model to predict the change of drug resistance to cisplatin in a mixed sensitive and resistant human cervical cancer cell population and then employed a cytosensitivity assay to evaluate if biological findings could confirm this change predicted by HK model. We used the HK model to predict the resistance to cisplatin in the mixed cell population. T...
A Mathematical Method to Easily and Accurately Measure the Tumor Volume of Prostate Cancer on Pathological Slides
John Zihou Chen, Monika Wrzolek, Lynne Opitz and Jianli Chen
Article Type: Original Research Article | First Published: September 21, 2019
For decades, it has been a big challenge to directly and accurately measure an irregularly shaped area for a tumor volume evaluation of prostate cancer. All current methods are not ideal for different reasons. An objective, practical, accurate, and reliable method for measuring of prostate cancer volume is needed, in particular in modern precision medicine setting, pursuing accuracy and quality of health care. In this study, we applied a mathematical method - the Gauss area calculation formula t...
Comparative Immunohistochemical Staining for Chromogranin A and Synaptophysin in Intestinal Carcinoids
Article Type: Research Article | First Published: September 16, 2019
Duodenal and ileal carcinoids were strongly positive for CgA, with or without invasion through intestinal wall. Small appendiceal carcinoids were weakly immunostained for CgA and SPY. Colorectal carcinoids were low-grade tumors especially those of small polypoid tumors (< 1.0 cm) with CgA-negative staining while larger tumors (> 2.0 cm) infiltrating through wall were more aggressive with often CgA positive staining. CgA positive carcinoids of duodenum, small intestine and colorectum of larger th...
Acrometastasis to Foot Revealing an Occult Lung Adenocarcinoma: Case Report and Literature Review
Ignez Candeloro and Bruno de Carvalho Dornelas
Article Type: Case Report and Literature Review | First Published: September 11, 2019
Metastases to the foot bones are uncommon and they mimic inflammatory conditions. Acrometastases may be the first manifestation of an unknown primary malignant disease. We report a case in which the first sign of lung adenocarcinoma was a pathological fracture due to metastasis to a proximal toe phalanx. A 68-year-old man was evaluated for pain in his fifth toe of the left foot after a trauma. Biopsy and immunohistochemistry reactions confirmed the metastatic lesion. Unfavorable clinical course ...
Extra-Nodal Non-Cutaneous Peripheral T cell Lymphoma: Common Peripheral Blood Findings and Clinical Follow Up
Hongwei Ma, Catherine Xie, Mohamed Masoud, Robin Williams and Ming Xie
Article Type: Research Article | First Published: September 07, 2019
Peripheral T cell lymphoma (TCL) is relatively uncommon and may involve lymph node, skin and extra-nodal non-cutaneous organs. Nodal TCL often presents as systemic disease with unfavorable outcomes. Extra-nodal non-cutaneous TCL, however, may remain as localized disease and be treated differently with favorable prognosis. This study revealed the common peripheral blood findings and clinical follow ups in patients with extra-nodal non-cutaneous mature TCL. There were 9 patients, 5 males and 4 fem...
Retroperitoneal Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature
Gumusay Ozge, Koseoglu Resit Dogan, Arici Akgul and Akin Ali
Article Type: Case Report | First Published: August 29, 2019
Solitary fibrous tumor is a rare soft-tissue neoplasm that is capable of metastasis of fibroblastic/ myofibroblastic cell origin. Although most of the cases are pleural in origin, extrapleural locations are reported with increasing frequency. Extrapleural cases are mostly seen in retroperitoneal location. Malignant forms are much rarer. The hemangiopericytomatous pattern is seen in many soft tissue tumors. Many cases with extrapleural/ extrathoracal locations that were previously diagnosed as he...
Adenomatoid Tumor in the Fallopian Tube - A Rare Case
Geetika Goyal, DNB, MD, Arati Inamdar, MD and Abraham Loo, MD
Article Type: Case Report | First Published: July 27, 2019
Adenomatoid tumors are benign tumors of mesothelial origin seen in female genitourinary tract, most commonly involving the uterus and rarely fallopian tubes. We herein report a case of 46-year-old female who presented with abnormal vaginal bleeding with complex cyst in left adnexa and multiple leiomyomata upon pelvic imaging. Hysterectomy and bilateral salpingectomy were done. A circumscribed red-tan nodule, measuring 3.0 cm in maximum dimensions was identified on the left fallopian tube with a ...
Influence of Image Manipulation Restricted to Global Alterations on Diagnosis by an Oral Cytologist
Aman Chowdhry, Keya Sircar and Deepika Bablani Popli
Article Type: Original Research | First Published: July 24, 2019
Cytology has always proudly been in forefront to absorb new technologic advances for practical use. The extensive and passionate implementation of digital imaging in telecytology, automated screening, education, training and certification, research, and publications is an appropriate example. Digitalization cytology records make its manipulation very simple. Several such manipulations, however, correspond to inappropriate changes and can affect final diagnosis of digital slides....
Craniopharyngioma Brain Invasion Forms
Martha Lilia Tena-Suck, Ma Elena Hernandez-CaMartha Lilia Tena-Suck, Ma Elena Hernandez-Campos, Alma Ortiz Plataa, Carlos Sanchez-Garibay, Citlaltepetl Salinas Lara and Carlos Penafielmpos, Alma Ortiz Plataa, Carlos Sanchez-Garibay, Citlaltepetl Salinas Lara and Carlos Penafiel
Article Type: Original Research | First Published: July 11, 2019
Craniopharyngiomas constitute 2 to 4% of intracranial neoplasms. Although this tumors exhibit a benign histopathological pattern, recurrence is commonly reported by cerebrospinal fluid seeding and direct brain invasion. The aim of this study was to analyses and recognizes craniopharyngioma pathological features in relationship to brain invasion as a prognostic factor. One hundred patients who were surgically treated for Craniopharyngiomas extending outside the sellar and suprasellar regions were...