International Journal of

Pathology and Clinical ResearchISSN: 2469-5807


 Open Access DOI:10.23937/2469-5807/1510110

Importance of Family Studies with High Performance Liquid Chromatography (HPLC) in Hemoglobin Disorders: An analysis of 37 Families

Dr. Mahesh Garje, Dr. Bharat R Sonwane, Dr. Shruti Gupta and Dr. Piyush Narkhede

Article Type: Original Article | First Published: May 22, 2020

The hemoglobin inherited disorders are one of the commonest single-gene disorders in man. Frequency of carriers of hemoglobinopathies varies from 3 to 17% in India. It is estimated that around 5.35% in India are the trait of Sickle cell, hemoglobin D, and hemoglobin E. However, the definite identification of disorders of hemoglobin synthesis can be achieved only by DNA analysis. In Indian scenario, family studies can be equally efficacious and cost-effective tool on HPLC and might be useful. Thi...

 Open Access DOI:10.23937/2469-5807/1510109

Giant Ectopic Parathyroid Adenoma of the Mediastinum Causing Primary Hyperparathyroidism - A Rare Case Report with Review of Literature

Swetha Narla, Sasankh RK, Annapurneswari S and Chandrasekaran Maharajan

Article Type: Case Report | First Published: May 01, 2020

Primary hyperparathyroidism is characterized by high parathyroid hormone levels and calcium levels which is most commonly due to a parathyroid adenoma. Ectopic parathyroid adenoma is very rare and is the cause for failed primary surgery. Common sites include mediastinum, path of vagus nerve, recurrent laryngeal nerve and intrathyroidal locations. Combination of imaging techniques including Sestamibi scan is very useful in locating an ectopic parathyroid adenoma and helps to avoid re explorative ...

 Open Access DOI:10.23937/2469-5807/1510108

α-Smooth Muscle Actin and TLR9 Expression and Correlation in Breast Cancer

Aradhana Singh, Arghya Bandyopadhyay, Narendranath Mukherjee and Anupam Basu

Article Type: Original Article | First Published: April 25, 2020

Cancer microenvironment is a complex of different kinds of cells. Ligands of different Toll-like receptors has been used in clinical trials in past decade but the mixed outcome leads to further studies. Toll-like receptor 9 expression has been observed in different type of cancer. α-Smooth muscle actin (α-SMA) is an indicator of myofibroblast. In previous studies, myofibroblasts was reported to induce angiogenesis and proliferation in cancer by providing growth factors and extracellular matrix...

 Open Access DOI:10.23937/2469-5807/1510107

Clinicopathological Correlation and Varied Histomorphological Changes in Xanthogranulomatous Cholecystitis (XGC)

Sufian Zaheer, Minakashi Chouhan, Sachin S Kolte and Rashmi Arora

Article Type: Original Article | First Published: April 23, 2020

Xanthogranulomatous cholecystitis (XGC) is a rare inflammatory disease of the gallbladder characterized by focal or diffuse destructive inflammation of the gall bladder comprising of mainly chronic inflammatory cells, fibrous tissue and lipid laden macrophages. The present study correlated the clinicopathological findings and studied the various histomorphological changes in Xanthogranulomatous cholecystitis (XGC). In a period of one year from January 2018 to June 2019, 22 patients were diagnose...

 Open Access DOI:10.23937/2469-5807/1510106

Intraventricular Pilocytic Astrocytoma in an Adult Patient

Joshua Hendrix and Zhenggang Xiong, MD, PhD

Article Type: Case Report | First Published: March 16, 2020

Pilocytic astrocytoma’s are tumors of the central nervous system mostly during the first two decades of life. Although they are mostly common in the midline structures of children, pilocytic astrocytoma within the ventricular system of an adult is rare. To our knowledge, only one single histologically and molecularly confirmed case was documented in the literature up to this time. We report a case of a 38-yearold woman with obstructive hydrocephalus secondary to a brain tumor within the third ...

 Open Access DOI:10.23937/2469-5807/1510105

Extrarenal Rhabdoid Tumour of Soft Tissue

Herbert Plasschaert, Frederik Deman, Isabelle Vanden Bempt, Veerle Labarque, Michael Aertsen, Hilde Brems and Raf Sciot

Article Type: Case Report | First Published: March 14, 2020

Extrarenal rhabdoid tumours appearing in the soft tissues are very rare and might be confused with other high-grade sarcomas harbouring rhabdoid features. We present a case and highlight the differential diagnosis, the ancillary techniques necessary to define its true rhabdoid nature, and the existence of hereditary syndromes. Our case concerns a new-born boy with a congenital and rapidly growing mass in the soft tissue of the left thoracic wall, expanding from a few cm in diameter at the time o...

Volume 6
Issue 1