Importance of Family Studies with High Performance Liquid Chromatography (HPLC) in Hemoglobin Disorders: An analysis of 37 Families
Dr. Mahesh Garje, Dr. Bharat R Sonwane, Dr. Shruti Gupta and Dr. Piyush Narkhede
Article Type: Original Article | First Published: May 22, 2020
The hemoglobin inherited disorders are one of the commonest single-gene disorders in man. Frequency of carriers of hemoglobinopathies varies from 3 to 17% in India. It is estimated that around 5.35% in India are the trait of Sickle cell, hemoglobin D, and hemoglobin E. However, the definite identification of disorders of hemoglobin synthesis can be achieved only by DNA analysis. In Indian scenario, family studies can be equally efficacious and cost-effective tool on HPLC and might be useful. Thi...
α-Smooth Muscle Actin and TLR9 Expression and Correlation in Breast Cancer
Aradhana Singh, Arghya Bandyopadhyay, Narendranath Mukherjee and Anupam Basu
Article Type: Original Article | First Published: April 25, 2020
Cancer microenvironment is a complex of different kinds of cells. Ligands of different Toll-like receptors has been used in clinical trials in past decade but the mixed outcome leads to further studies. Toll-like receptor 9 expression has been observed in different type of cancer. α-Smooth muscle actin (α-SMA) is an indicator of myofibroblast. In previous studies, myofibroblasts was reported to induce angiogenesis and proliferation in cancer by providing growth factors and extracellular matrix...
Clinicopathological Correlation and Varied Histomorphological Changes in Xanthogranulomatous Cholecystitis (XGC)
Sufian Zaheer, Minakashi Chouhan, Sachin S Kolte and Rashmi Arora
Article Type: Original Article | First Published: April 23, 2020
Xanthogranulomatous cholecystitis (XGC) is a rare inflammatory disease of the gallbladder characterized by focal or diffuse destructive inflammation of the gall bladder comprising of mainly chronic inflammatory cells, fibrous tissue and lipid laden macrophages. The present study correlated the clinicopathological findings and studied the various histomorphological changes in Xanthogranulomatous cholecystitis (XGC). In a period of one year from January 2018 to June 2019, 22 patients were diagnose...
Intraventricular Pilocytic Astrocytoma in an Adult Patient
Joshua Hendrix and Zhenggang Xiong, MD, PhD
Article Type: Case Report | First Published: March 16, 2020
Pilocytic astrocytoma’s are tumors of the central nervous system mostly during the first two decades of life. Although they are mostly common in the midline structures of children, pilocytic astrocytoma within the ventricular system of an adult is rare. To our knowledge, only one single histologically and molecularly confirmed case was documented in the literature up to this time. We report a case of a 38-yearold woman with obstructive hydrocephalus secondary to a brain tumor within the third ...
Extrarenal Rhabdoid Tumour of Soft Tissue
Herbert Plasschaert, Frederik Deman, Isabelle Vanden Bempt, Veerle Labarque, Michael Aertsen, Hilde Brems and Raf Sciot
Article Type: Case Report | First Published: March 14, 2020
Extrarenal rhabdoid tumours appearing in the soft tissues are very rare and might be confused with other high-grade sarcomas harbouring rhabdoid features. We present a case and highlight the differential diagnosis, the ancillary techniques necessary to define its true rhabdoid nature, and the existence of hereditary syndromes. Our case concerns a new-born boy with a congenital and rapidly growing mass in the soft tissue of the left thoracic wall, expanding from a few cm in diameter at the time o...