Crystal-Storing Histiocytosis in a Patient with Nodal Marginal Zone Lymphoma
Madeline Fitzpatrick, MD, Amrah Pirzada, MD and Offiong Ikpatt, MD
Article Type: Case Report | First Published: December 24, 2022
We present a case of a 72-year-old male diagnosed with concurrent crystal-storing histiocytosis and nodal marginal zone lymphoma with plasmacytic differentiation following a finding of new axillary lymphadenopathy during active surveillance for an early stage lung cancer. A panel of ancillary studies was performed to help establish the diagnosis and to exclude other histologic mimics. We share this case to promote awareness of this rare entity, discuss its association with immunoglobulin-produci...
Pathological Changes in Postmortem Covid-19 Biopsies
Alexis J Leon-Guerrero, MD, Nazario A Ortiz-Muchotrigo, MD, Paola G Gutierrez-Gutierrez, MD, Alejandra M Bahamonde-Pacheco, MD, Lis N Zelada-Hernandez, MD, Daniela I Medina-Valdivia, MD, Cesar A Chian-Garcia, MD and Fiorella Rosas, MD
Article Type: Case series and literature review | First Published: November 23, 2022
The COVID-19 epidemic has caused thousands of deaths all over the world. This virus is known to produce an atypical pneumonia that can lead to death. There are few studies concerning pathological examination of tissues from COVID-19 patients. To describe the pathological findings in tissues from deceased patients with COVID-19 infection....
Expression of Vitamin D Receptor (VDR) in Urinary Bladder Carcinoma: Immunohistochemical and Histopathological Study
Rehab Mohamed Sharaf Eldin, MD, Basma Mostafa Mahmoud Abdalla, MSc, Samia Ibrahim El Naggar, MD and Wesam Ismail Moustafa, MD
Article Type: Original Article | First Published: November 19, 2022
Bladder cancer is the most common malignancy of the urinary tract. Calcitriol [1,25(OH)2 vitamin D3] has anticancer effects mediated through binding to vitamin D receptor (VDR). The expression of VDR is present in many normal and cancer tissues. But there is little information about its expression in urinary bladder carcinoma. This study aimed to analyze VDR immunohistochemical expression in 74 Egyptian patients with urinary bladder carcinoma and to evaluate its association with different clinic...
Do Messenger RNA Vaccines Induce Pathological Syncytia?
Adonis Sfera, MD, Karina G Thomas, DAN O Sfera, Jonathan J Anton, Christina V Andronescu, Nyla Jafri, Sarvin Sasannia and Zisis Kozlakidis
Article Type: Review Article | First Published: October 20, 2022
The Pfizer and Moderna COVID-19 vaccines are composed of lipid nanoparticles (LNP) containing a modified messenger RNA (mRNA) that encodes for the Spike S protein. The LNP transfection likely involves particle engulfment by the host immune cells due to their resemblance to apoptotic bodies, vesicles with externalized phosphatidylserine (ePS). As the LNPs are decorated with PS-like ionizable phospholipids, including 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), they encourage human phagocyte...
PRAME Expression in Mimickers of Melanoma in Situ: Paget’s Disease, Extramammary Paget’s Disease, and Pagetoid Squamous Cell Carcinoma in Situ
Cary Chisholm, MD, Michael Hatch, MD, Sage Post and Sage Chain
Article Type: Research Article | First Published: August 19, 2022
Antibodies towards Preferentially Expressed Antigen in Melanoma (PRAME) have shown promise to discriminate between melanoma in situ (MIS) and benign melanocytic lesions. Paget’s disease, extramammary Paget’s disease, and squamous cell carcinoma in situ may mimic the morphologic features of MIS, and PRAME expression in these lesions has not yet been described....
Monoclonal Light Chains in Multiple Myeloma: The Sinister Immunoglobulin
Gurmukh Singh, MD, PhD, MBA, Hongyan Xu, PhD and Roni J Bollag, MD, PhD
Article Type: Clinical Research | First Published: August 04, 2022
Multiple myelomas are the commonest hematological malignancy in adults, next to the heterogeneous group non- Hodgkin lymphomas, and account for about 10% of such tumors. About 21% of the multiple myelomas are associated with higher levels of free monoclonal light chains. This subgroup of patients exhibits high incidence of renal disease manifested by significantly lower estimated glomerular filtration rate, higher incidence of dialysis and significantly shorter survival....
Cellular Angiofibroma: A Rare Tumor Behind the Ear
Canan Firat, Ayca Ersen Danyeli, Yuksel Olgun and Sulen Sarioglu
Article Type: Case Report | First Published: July 28, 2022
Cellular angiofibroma (CA) is an uncommon benign soft tissue tumor and typically arises in genitourinary region. There are only three reported cases at the head and neck region to the best of our knowledge; two different sites at eyelid and buccal mucosa. A 67-year-old man presented to the otorhinolaryngology unit with a painless nodule behind the left ear. Ultrasonography revealed a subcutaneous non-vascular, hyperechoic, homogenous, solid, 15×15 mm mass....
Hidradenocarcinoma Treated with Mohs Surgery
Jenna Lee, MS, Carolina Puyana, MD, MSPH, Wenhua Liu, MD, Vassilios Dimitropoulous, MD and Roger Haber, MD
Article Type: Case Report | First Published: August 18, 2022
Hidradenocarcinoma (HAC) is an exceedingly rare and aggressive malignant tumor of the adnexal eccrine and apocrine sweat gland. Due to its low incidence rate, nonspecific clinical presentation, and similar histopathological features to benign hidradenoma (HA), HAC is often misdiagnosed as its benign counterpart. Histologically, even the absence of cellular atypia does not rule out malignancy....
Primary Pulmonary Colloid Adenocarcinoma: A Case Report with Literature Review
Emna Braham, Farah Sassi, Mehdi Abdennadher, Mona Mlika and Faouzi El Mezni
Article Type: Case Report | First Published: July 16, 2022
Pulmonary colloid adenocarcinomas are uncommon tumors individualized as a distinct entity in the histological classification of World Health Organisation of lung tumors characterized by extensive pool of extracellular mucin distending and destroying alveolar walls. We herein report a case of a 63 year-old active man smoker who presented with a worsening dyspnea. A chest computed tomography scan showed a highly suspected irregular nodule of 23 mm in the left-upper lobe....