International Journal of

Pathology and Clinical ResearchISSN: 2469-5807


 Open Access DOI:10.23937/2469-5807/1510142

Crystal-Storing Histiocytosis in a Patient with Nodal Marginal Zone Lymphoma

Madeline Fitzpatrick, MD, Amrah Pirzada, MD and Offiong Ikpatt, MD

Article Type: Case Report | First Published: December 24, 2022

We present a case of a 72-year-old male diagnosed with concurrent crystal-storing histiocytosis and nodal marginal zone lymphoma with plasmacytic differentiation following a finding of new axillary lymphadenopathy during active surveillance for an early stage lung cancer. A panel of ancillary studies was performed to help establish the diagnosis and to exclude other histologic mimics. We share this case to promote awareness of this rare entity, discuss its association with immunoglobulin-produci...

 Open Access DOI:10.23937/2469-5807/1510141

Sinus Histiocytosis with Massive Lymphadenopathy (Rosai Dorfman Disease) of the Liver Masquerading as a Metastatic Malignancy

Sheba SK Jacob and Elankumaran Krishnan

Article Type: Case Report | First Published: December 01, 2022

Sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai Dorfman disease) is a disorder first described in lymph nodes but eventually has been described in many organs. Liver involvement is rare and is a great mimicker of infection, metastases or a lymphoma which commonly involve the liver. We describe a case of a middle-aged female who presented with abdominal pain in the emergency. CT scan of the upper abdomen showed multiple hypodense lesions in the liver, pancreas, left sacral ala and ...

 Open Access DOI:10.23937/2469-5807/1510140

Pathological Changes in Postmortem Covid-19 Biopsies

Alexis J Leon-Guerrero, MD, Nazario A Ortiz-Muchotrigo, MD, Paola G Gutierrez-Gutierrez, MD, Alejandra M Bahamonde-Pacheco, MD, Lis N Zelada-Hernandez, MD, Daniela I Medina-Valdivia, MD, Cesar A Chian-Garcia, MD and Fiorella Rosas, MD

Article Type: Case series and literature review | First Published: November 23, 2022

The COVID-19 epidemic has caused thousands of deaths all over the world. This virus is known to produce an atypical pneumonia that can lead to death. There are few studies concerning pathological examination of tissues from COVID-19 patients. To describe the pathological findings in tissues from deceased patients with COVID-19 infection....

 Open Access DOI:10.23937/2469-5807/1510139

Expression of Vitamin D Receptor (VDR) in Urinary Bladder Carcinoma: Immunohistochemical and Histopathological Study

Rehab Mohamed Sharaf Eldin, MD, Basma Mostafa Mahmoud Abdalla, MSc, Samia Ibrahim El Naggar, MD and Wesam Ismail Moustafa, MD

Article Type: Original Article | First Published: November 19, 2022

Bladder cancer is the most common malignancy of the urinary tract. Calcitriol [1,25(OH)2 vitamin D3] has anticancer effects mediated through binding to vitamin D receptor (VDR). The expression of VDR is present in many normal and cancer tissues. But there is little information about its expression in urinary bladder carcinoma. This study aimed to analyze VDR immunohistochemical expression in 74 Egyptian patients with urinary bladder carcinoma and to evaluate its association with different clinic...

 Open Access DOI:10.23937/2469-5807/1510138

Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

Gaurvi Piplani and Teerthanath S

Article Type: Original Article | First Published: October 28, 2022

Bone marrow examination is an important diagnostic tool widely used in various haematological and non-haematological disorders. Bone marrow evaluation may either confirm clinically suspected disease or may provide the previously unsuspected diagnosis. To study the spectrum of lesions, comparison and evaluation of diagnostic efficacy of the bone marrow aspiration and bone marrow biopsy findings in various haematological and non-haematological disorders....

 Open Access DOI:10.23937/2469-5807/1510137

Do Messenger RNA Vaccines Induce Pathological Syncytia?

Adonis Sfera, MD, Karina G Thomas, DAN O Sfera, Jonathan J Anton, Christina V Andronescu, Nyla Jafri, Sarvin Sasannia and Zisis Kozlakidis

Article Type: Review Article | First Published: October 20, 2022

The Pfizer and Moderna COVID-19 vaccines are composed of lipid nanoparticles (LNP) containing a modified messenger RNA (mRNA) that encodes for the Spike S protein. The LNP transfection likely involves particle engulfment by the host immune cells due to their resemblance to apoptotic bodies, vesicles with externalized phosphatidylserine (ePS). As the LNPs are decorated with PS-like ionizable phospholipids, including 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), they encourage human phagocyte...

 Open Access DOI:10.23937/2469-5807/1510136

Congenital Cystic Pulmonary Airway Malformation with Intralobar Sequestration in 15 Weeks Old Fetus- Peculiarity of Early Developmental Stage

Daria Kozlova, Sharon Perlman, Roee Birnbaum, Ori Mayer and Yinon Gilboa

Article Type: Case Report | First Published: August 20, 2022

Congenital pulmonary airway malformations (CPAMs) consist of a spectrum of cystic or non-cystic lung malformations often associated with bronchial atresia during in utero development. Several classifications for these lesions have been proposed using radiologic or pathologic criteria based on cyst size and histology, with the Stocker classification being perhaps the most commonly used in the pathology literature....

 Open Access DOI:10.23937/2469-5807/1510135

PRAME Expression in Mimickers of Melanoma in Situ: Paget’s Disease, Extramammary Paget’s Disease, and Pagetoid Squamous Cell Carcinoma in Situ

Cary Chisholm, MD, Michael Hatch, MD, Sage Post and Sage Chain

Article Type: Research Article | First Published: August 19, 2022

Antibodies towards Preferentially Expressed Antigen in Melanoma (PRAME) have shown promise to discriminate between melanoma in situ (MIS) and benign melanocytic lesions. Paget’s disease, extramammary Paget’s disease, and squamous cell carcinoma in situ may mimic the morphologic features of MIS, and PRAME expression in these lesions has not yet been described....

 Open Access DOI:10.23937/2469-5807/1510134

Monoclonal Light Chains in Multiple Myeloma: The Sinister Immunoglobulin

Gurmukh Singh, MD, PhD, MBA, Hongyan Xu, PhD and Roni J Bollag, MD, PhD

Article Type: Clinical Research | First Published: August 04, 2022

Multiple myelomas are the commonest hematological malignancy in adults, next to the heterogeneous group non- Hodgkin lymphomas, and account for about 10% of such tumors. About 21% of the multiple myelomas are associated with higher levels of free monoclonal light chains. This subgroup of patients exhibits high incidence of renal disease manifested by significantly lower estimated glomerular filtration rate, higher incidence of dialysis and significantly shorter survival....

 Open Access DOI:10.23937/2469-5807/1510133

Assessment of Serum Copper and Zinc Status in Patients Receiving Highly Active Antiretroviral Therapy in A Tertiary Health Institution in Southwest Nigeria

Taiwo Oloyede, Elizabeth Oke, Taiwo Alatishe, Samson Ojedokun, Adeolu Akinboro, Kunle Oreagba and Abdulkareem Afolabi Salawu

Article Type: Original Research | First Published: July 30, 2022

The poor prognosis and mortality in HIV infection has been associated with deficiency of micronutrients such as zinc and copper. This study aimed to investigate the level and deficiency of some trace elements in HIV-seropositive subjects receiving HAART treatment....

 Open Access DOI:10.23937/2469-5807/1510132

Basal-Like Atypical Ductal Hyperplasia and Basal-Like Ductal Carcinoma In Situ: Evidence for Precursor of Basal-Like Breast Cancer

Jing Wang and Lavinia P. Middleton

Article Type: Original Article | First Published: July 28, 2022

Basal-like breast cancer (BLBC) is identified by gene expression profiling studies and is associated with worse overall survival. The identification of possible precursors of BLBC is important to gain insight into tumorigenesis and therapeutic targets. This retrospective study evaluated the characteristics of possible precursors of BLBC, including basal-like atypical ductal hyperplasia (bADH) and basal-like ductal carcinoma in situ (bDCIS); basal cytokeratin (CK) expression in bADH and bDCIS; an...

 Open Access DOI:10.23937/2469-5807/1510131

Cellular Angiofibroma: A Rare Tumor Behind the Ear

Canan Firat, Ayca Ersen Danyeli, Yuksel Olgun and Sulen Sarioglu

Article Type: Case Report | First Published: July 28, 2022

Cellular angiofibroma (CA) is an uncommon benign soft tissue tumor and typically arises in genitourinary region. There are only three reported cases at the head and neck region to the best of our knowledge; two different sites at eyelid and buccal mucosa. A 67-year-old man presented to the otorhinolaryngology unit with a painless nodule behind the left ear. Ultrasonography revealed a subcutaneous non-vascular, hyperechoic, homogenous, solid, 15×15 mm mass....

 Open Access DOI:10.23937/2469-5807/1510130

Hidradenocarcinoma Treated with Mohs Surgery

Jenna Lee, MS, Carolina Puyana, MD, MSPH, Wenhua Liu, MD, Vassilios Dimitropoulous, MD and Roger Haber, MD

Article Type: Case Report | First Published: August 18, 2022

Hidradenocarcinoma (HAC) is an exceedingly rare and aggressive malignant tumor of the adnexal eccrine and apocrine sweat gland. Due to its low incidence rate, nonspecific clinical presentation, and similar histopathological features to benign hidradenoma (HA), HAC is often misdiagnosed as its benign counterpart. Histologically, even the absence of cellular atypia does not rule out malignancy....

 Open Access DOI:10.23937/2469-5807/1510129

Primary Pulmonary Colloid Adenocarcinoma: A Case Report with Literature Review

Emna Braham, Farah Sassi, Mehdi Abdennadher, Mona Mlika and Faouzi El Mezni

Article Type: Case Report | First Published: July 16, 2022

Pulmonary colloid adenocarcinomas are uncommon tumors individualized as a distinct entity in the histological classification of World Health Organisation of lung tumors characterized by extensive pool of extracellular mucin distending and destroying alveolar walls. We herein report a case of a 63 year-old active man smoker who presented with a worsening dyspnea. A chest computed tomography scan showed a highly suspected irregular nodule of 23 mm in the left-upper lobe....

Volume 8
Issue 2