Open Access DOI:10.23937/2469-5769/1510047
D-Penicillamine in the Neonatal Period: Past (!), Present (!?) and Future (?!)
Lajos Lakatos
Article Type: Case Report | First Published: December 01, 2018
D-penicillamine (D-PA) was first recognized as a potential benefit for neonatal hyperbilirubinemia (NHBI) caused by hemolytic diseases of the newborn infant or immaturity of UDP-glucuronyltransferase enzyme. During a long-term follow up study there was a remarkedly low incidence of retrolental fibroplasia (RLF) in the infants treated with D-PA in their neonatal period. Then, all infants < 1500 g birthweight were treated with D-PA to prevent retinopathy of prematurity (ROP). This preventive inter...
Open Access DOI:10.23937/2469-5769/1510046
Associations between Maturity Status and Dietary Intake in Austrian Adolescents
Clemens Drenowatz and Klaus Greier
Article Type: Research Article | First Published: November 19, 2018
Dietary intake plays an important role in the development and health of children and adolescents. Puberty is a particularly vulnerable period due to the increased nutrient demands associated with growth. This age range has also been associated with various changes in health behavior. While several studies have examined the influence of the social and built environment on dietary habits during adolescence, there remains limited research on the association between biological maturation and eating ...
Open Access DOI:10.23937/2469-5769/1510045
Acute Necrotizing Encephalopathy in Children: A Case Report and Literature Review
Ping Yuan and Min Zhong
Article Type: Case Report | First Published: November 16, 2018
Acute necrotizing encephalopathy (ANE) is a rare clinical-imaging syndrome with unknown etiology, characterized by acute fulminant severe encephalopathy and brain damage with multifocal symmetry. ANE has no specific clinical symptoms and signs, similar to common encephalitis or encephalopathy symptoms. The characteristic brain imaging examination is diagnostically significant. To date, no specific treatment for ANE is available and the prognosis is poor. Here, we reported a typical case of ANE i...
Open Access DOI:10.23937/2469-5769/1510044
Childhood Fever Knowledge and Management: A Case of Mothers with Children under Five Years
Reindolf Anokye, Rita Amihere, Patience Abbiaw, Enoch Acheampong, Naomi Gyamfi and Amy Budu-Ainooson
Article Type: Original Article | First Published: November 15, 2018
Most childhood ailments often present with fever which account for the most common reasons why parents seek medical care for their children; particularly, the under-five children. The study aimed to assess the mothers' knowledge of fever in their under-five children and how this is managed at home. This was a descriptive designed study that used a simple random sampling technique to select 100 participants who were mothers of under-five children who presented to the Kwahu Government Hospital, At...
Open Access DOI:10.23937/2469-5769/1510043
A Novel ATP1A2 Mutation in Pediatric Hemiplegic Migraine
Christopher J Butler and Andrew Mallick
Article Type: Case Report | First Published: November 02, 2018
Migraine is a common pediatric disorder presenting with unilateral frontal headache. Hemiplegic migraine is a rare and clinically challenging subtype of migraine with aura. There are two different subtypes of hemiplegic migraines; they can occur as either sporadic or familial forms. Recently our understanding of the genetics underlying hemiplegic migraine has rapidly evolved. Familial hemiplegic migraine has been associated with pathogenic mutations in three independent genes. Migraine is a comm...
Open Access DOI:10.23937/2469-5769/1510042
Birthweight and Gestational Age: Early Life Management Strategy to Population Health for Non-Communicable Diseases
Issa Al Salmi and Suad Hannawi
Article Type: Research Article | First Published: October 31, 2018
Non-communicable diseases (NCD) are rising throughout the globe over the last few decades. Developing countries bear the worse burden of these NCD. Similarly, low birthweight is increasing around the world where most of this prevalence commonly seen in the developing countries but as well in the well-developed countries where advancement of health care managed to increase the survival of the very low birthweight babies. In recent years, there has been great interest in the early development of t...
Open Access DOI:10.23937/2469-5769/1510041
Hemophagocytic Lymphohistiocytosis Secondary to H1N1 Pneumonia: A Case Report
Manoj D, Vinayaka HS and Basavaraj GV
Article Type: Case Report | First Published: October 24, 2018
Hemophagocytic Lymphohistiocytosis (HLH) describes a clinical syndrome of hyperinflammation resulting in uncontrolled and ineffective immune response. It may be primary or secondary HLH. Primary HLH is better defined as "genetic" encompassing both the familial hemophagocytic lymphohistiocytosis (FHL) and also HLH occurring in association with Chediak-Higashi syndrome, Griscelli syndrome type 2 and X-linked lymphoproliferative disorder. FHL is inherited as an autosomal recessive manner. The incid...
Open Access DOI:10.23937/2469-5769/1510040
Histopathological Fate in the Inguinal Hernia Sac in the Children
Mustafa Yasar Ozdamar
Article Type: Original Research | First Published: October 19, 2018
Obliteration of the processus vaginalis during the fetal growth begins with a transient decrease in sympathetic tonus and then ends with smooth muscle cells (SMCs) undergoing apoptosis. Otherwise, an inguinal hernia (IH) occurs due to the defective obliteration. Although the mechanism in the formation of an inguinal hernia has been elucidated by many investigations, it has not been investigated whether proliferation in the IH sac cells which would lead to the benign or malignant process. In this...
Open Access DOI:10.23937/2469-5769/1510039
Pediatric Nature of Enteric Fever with Emerging Antibiogram: A Cross Sectional Study
Sameer Sarswat, Mithilesh Kumar and Raju Gupta
Article Type: Original Article | First Published: October 05, 2018
Typhoid fever is a life-threatening systemic infection occurring in developing countries like India. The presenting signs and symptoms of typhoid fever in children differ from adults. Some studies indicate reemergence of sensitivity of Salmonella with chloramphenicol. 164 children between 1-12 years of age with suspected enteric fever were enrolled in the study. Out of these, 73 patients were diagnosed as enteric fever and clinical features were compared among different age groups. Antibiotic se...
Open Access DOI:10.23937/2469-5769/1510038
Impact of Double Volume Exchange Transfusion on Biochemical Parameters in Neonatal Hyperbilirubinemia
Mohd Ibrahim Wani, Mudasir Nazir, Roumissa Lone, Mohd Rafiq, Syed Wajid Ali and Bashir Ahmad Charoo
Article Type: Research Article | First Published: October 05, 2018
Almost 60% of normal healthy term babies and 80% of preterm babies develop visible jaundice in the first week of life. Although the outcome of the majority is benign, newborns with untreated severe hyperbilirubinemia can develop short and long-term sequelae of bilirubin encephalopathy. This study was designed to evaluate the impact of exchange transfusion on various biochemical parameters and to assess the need for routine calcium gluconate supplementation during the procedure....
Open Access DOI:10.23937/2469-5769/1510037
Lifestyle, Diet and Body Mass Index in Offspring of Women with Pregestational and Gestational Diabetes
Nurah M Hammoud, Harold W de Valk, Lenie van Rossem, Geertje W Dalmeijer, Douwe H Biesma, Jan M Wit, Maarten Rijpert and Gerard HA Visser
Article Type: Research Article | First Published: October 05, 2018
Offspring from women with diabetes have an increased risk for childhood obesity, which may be related to the abnormal intrauterine environment, genetic imprinting or current diet and lifestyle. We analyzed whether diet and lifestyle differ between offspring from women with either type 1, type 2 or gestational diabetes. We collected completed questionnaires from parents of 51 offspring from women with type 1 diabetes (ODM1), 21 of women with type 2 diabetes (ODM2) and 87 of women with gestational...
Open Access DOI:10.23937/2469-5769/1510035
Congenital Cytomegalovirus Infection Presenting as Severe Conjugated Hyperbilirubinemia on First Day of Life
Aaradhana Singh and Ravi Sachan
Article Type: Case Report | First Published: July 12, 2018
Congenital Cytomegalovirus infection (CMV) has varied presentations ranging from asymptomatic to involvement of multiple organ systems like central nervous system, gastrointestinal, hepatic and hematopoietic. Jaundice is a manifestation of congenital CMV presenting as neonatal hepatitis or cholestasis jaundice. We report a case of severe conjugated hyperbilirubinemia presenting on the first day of life that was diagnosed as a case congenital CMV on further workup....
