Heart-Lung Acting Together
Robert S Fitzgerald
Article Type: Review Article | First Published: December 12, 2018
Most frequently medical education treats the pulmonary system and the cardiovascular system separately. And this is, indeed, quite understandable because each system's pathologies and their treatments differ in so many ways. However, from another perspective, the physiologist's, both systems are the evolutionary product for capturing oxygen from the external environment and delivering it to the mitochondria in the body's cells for the generation of the energy needed for life's operations. Bound ...
A Comparison between Two Pathophysiologically Different yet Microbiologically Similar Lung Diseases: Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
Daniel E Fenker, Cameron T McDaniel, Warunya Panmanee, Ralph J Panos, Eric J Sorscher, Carleen Sabusap, John P Clancy and Daniel J Hassett
Article Type: Review Article | First Published: November 29, 2018
Cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are chronic pulmonary diseases that affect ~70,000 and 251 million individuals worldwide, respectively. Although these two diseases have distinctly different pathophysiologies, both cause chronic respiratory insufficiency that erodes quality of life and causes significant morbidity and eventually death. In both CF and COPD, the respiratory microbiome plays a major contributing role in disease progression and morbidity. Pulmona...
Correlation between Pentraxin-3 and Left Ventricular Diastolic Dysfunction in Obstructive Sleep Apnea
Jie-Ru Li, Xiu-Hua Gao, Ju-Qiang Han, Wen-Yan Luo and En-Sheng Ji
Article Type: Original Article | First Published: November 23, 2018
Obstructive sleep apnea (OSA) is one of independent dangerous factors for cardiovascular disease including heart failure. Recent studies demonstrated that left ventricular diastolic dysfunction (LVDD) and pentraxin-3 (PTX-3) are early signs for development of heart failure. The objective of our study was to estimate the relation between OSA severity and LVDD and PTX-3. Sixty-six OSA patients and 25 healthy people who underwent polysomnography to diagnose OSA were enrolled. Ninety-one participant...
The Importance of Posture and Gravity in the Pathophysiology of Obstructive Sleep Apnea
Article Type: Case Report | First Published: November 19, 2018
The objective of drafting this case report is to delineate the relationship between elephantiasis disease rarely encountered in clinical practice and sleep disordered breathing, to try to understand how this specific condition influences the quality of sleep, to review the mechanisms for Obstructive Sleep Apnea Syndrome which is the most common sleep disordered breathing seen and to underline its importance once again. Lymphedema is a chronic condition stemming from the insufficient drainage of ...
A Rare Case of Pulmonary Embolism Due to Endovascular Coil Embolization and Review of Literature
Francisco X Leon, Beatriz Alba, Alvaro Arribas, Raquel Garcia, Isabel Garcia and Carlos A Quezada
Article Type: Case Report | First Published: October 26, 2018
Coil embolization is an effective and safe treatment of pelvic congestion syndrome. Cases of coil pulmonary migration have been reported after pelvic embolization. However, most cases are usually asymptomatic and do not require specific treatment. We present the first case of pulmonary coil migration after pelvic embolization and concomitant acute pulmonary embolism in a symptomatic patient. The patient was treated with standard anticoagulation and conservative measures without incidences after ...
Leukopenia Induced by Anti-Tuberculosis Treatment
Belloumi N, Ben Bdira B, Bachouche I, Kacem M, Chermiti Ben Abdallah F and Fenniche S
Article Type: Case Report | First Published: October 25, 2018
Poor compliance to anti-tuberculosis treatment is sometimes related to its adverse effects. By reporting any unusual or severe treatment related accident, we try to enlarge our background in order to manage better any similar case. By writing this paper, up further evidence is provided for a better knowledge and management of ATT adverse events. Here we report a case of leukopenia induced by an anti-tuberculosis oral treatment. Our 43-years-old patient was diagnosed with pleural tuberculosis. B...
Identification and Molecular Epidemiology of Mycobacterial Isolates in Kayseri/Turkey
Murat KARAUZ, A Nedret KOC and Altay ATALAY
Article Type: Original Article | First Published: October 17, 2018
Early diagnosis and treatment of tuberculosis (TB) patients are the most effective ways to protect society from this disease. The objectives of this study were to evaluate the molecular epidemiology of mycobacterial strains by repetitive sequence PCR (rep-PCR) using the DiversiLab System method at Kayseri in Turkey. A total of fifteen clinically sample isolated Mycobacterial strains were identified as M. tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM) by the rep-PCR method (bi...
Pulmonary Functions in Volleyball and Basketball Players of Kolkata, India
Sohini Basu, Rishna Dalui, Anindita Singha Roy and Amit Bandyopadhyay
Article Type: Original Article | First Published: October 13, 2018
Assessment of lung function is an indispensable tool for determination of the health status in case of the athletes. Present study focused on evaluating the lung function parameters for the state-level male basketball players and male volleyball players of West Bengal, India apart from comparing the data with their age-matched healthy, sedentary male counterparts. Fitness of an individual may be adjudged by employing a battery of physiological test manoeuvres, and lung function test is one such ...
Well-Controlled Narcolepsy Patient Sleepy Again
Dmitriy Kogan and Kavita Ratarasarn
Article Type: Case Report | First Published: October 12, 2018
Narcolepsy is associated with high prevalence of comorbid sleep disorders. Overlap in symptoms of different disorders may confound management. Sleep Medicine practitioners need to be vigilant for presence or new development of comorbid conditions to provide effective and comprehensive care. We present a patient with Narcolepsy Type 2 who developed worsening hypersomnolence due to new onset Obstructive Sleep Apnea (OSA). Treatment of OSA resulted in improvement of hypersomnolence without requirin...
Lipid Profile Status in Chronic Obstructive Pulmonary Disease and its Association with Disease Severity
Sneh Arora, Rashi Jain, Anant Mohan, Pawan Tiwari and Randeep Guleria
Article Type: Original Article | First Published: October 12, 2018
Dyslipidemia is considered as the major risk factor for cardiovascular disease (CVD) and may contribute to the higher mortality in chronic obstructive pulmonary disease (COPD). However, the prevalence and consequences of dyslipidemia in COPD is still unclear. We studied comprehensive lipid profile panel including serum total cholesterol (TC), triglyceride (TG), low density lipoproteins (LDL), very low-density lipoproteins (VLDL) and high-density lipoproteins (HDL) in COPD patients to study the r...
Occupational Rhinitis and Asthma in the Textile Sector of the Central Region of Tunisia
Maoua M, Gaddour A, Rouis H, Kacem I, Guedri S, Aissa S, Ghammem M, Boughattas W, Brahem A, Kalboussi H, El Maalel O, Chatti S and Mrizak N
Article Type: Original Article | First Published: October 12, 2018
The association between occupational asthma (OA) and occupational allergic rhinitis (OAR) is often described in the literature supporting the concept of "United airways disease" based on a parallel significant reaction of the nose and lungs after challenges with occupational agents and involving several occupational, host-related and environmental factors and thus exacerbating the medical and socio-economic impact of the OR. In Tunisia, only limited studies were carried out to explore associatio...
Supine Sleep during Polysomnography and the Diagnosis of Obstructive Sleep Apnea
Dandan A, Dettenmeier P, Chang J and Espiritu JRD
Article Type: Original Article | First Published: August 23, 2018
Since the supine position worsens obstructive sleep apnea (OSA) by promoting upper airway collapse, patients may avoid supine sleep in order to mitigate its effects. However, the avoidance of supine sleep during polysomnography (PSG) may result in a missed diagnosis of OSA. This study aims to examine the association between the presence/absence of supine sleep and the diagnosis of OSA during PSG....
An Incidental Case of Pulmonary Amyloidosis
Fatih Uzer and Hulya Dirol
Article Type: Case Report | First Published: August 23, 2018
Amyloidosis is characterized by extra-cellular deposition of an insoluble fibrillary protein, amyloid in organs and tissues. It is classified as either primary or secondary based on the presence of concomitant diseases, ranging from chronic infection or inflammation to malignancy and as limited or systemic based on the extent of organ invasion. The clinical and radiological manifestations of amyloidosis are varrious and often nonspecific, making amyloidosis a diagnostic challenge....
Visual HRCT Score to Determine Severity and Prognosis of Idiopathic Pulmonary Fibrosis
Ricardo Peris Sanchez, Estrella Fernandez-Fabrellas, Gustavo Juan Samper, Maria Luisa Domingo Montanana and Lidia Navarro Vilar
Article Type: Original Article | First Published: August 16, 2018
High-resolution computed tomography (HRCT) is an essential technique for the diagnosis and follow-up of idiopathic pulmonary fibrosis (IPF), but it is not routinely used to evaluate severity. A semi-quantitative HRCT score was developed to determine its relation with physiologic variables, to assess severity and fibrosis progression, and to establish prognostic factors....
A Case of Primary Pulmonary Artery Intimal Sarcoma
Chiyo Yano, Masaki Tominaga, Keisuke Miwa, Yoshiko Naito, Yuki Sakazaki, Takuma Koga, Masaki Okamoto, Tomotaka Kawayama, Tomoaki Hoshino, Reiji Muto, Koichi Ohshima and Masanori Hisaoka
Article Type: Case Report | First Published: July 26, 2018
A 28-year-old Japanese woman complained of right chest pain, fever, and cough. Chest radiography revealed consolidation in her right lower lobe with a pleural effusion. She was diagnosed with pneumonia and treated with antibiotics, but her condition did not improve. She was referred to our hospital for evaluation. Contrast-enhanced computed tomography (CT) demonstrated a large saddle filling defect extending into the right pulmonary artery as well as the proximal lower lobe pulmonary artery bran...
Tuberculosis Diagnosis in Private Independent Laboratories in Kampala- Uganda Implications for TB Control in the City
D Lukoye, D Okello, S Namatovu, A SSebagereka, K Mutesasira, Mabumba Eldad, M Nandala and P Suarez
Article Type: Research Article | First Published: July 13, 2018
Tuberculosis remains the greatest killer globally. Uganda, one of the highest TB burden countries has a rapidly growing private medical sector. Although a large proportion of patients first seek care from the private sector, there is very little if any literature about participation of private independent laboratories in diagnosis of TB. We aimed at assessing this and the extent to which diagnosed TB patients are linked to care....