International Journal of

Stem Cell Research & TherapyISSN: 2469-570X


 Open Access DOI:10.23937/2469-570X/1410053

Stem Cell Therapy: Recent Success and Continuing Progress in Treating Diabetes

Elton Mathias, Roveena Goveas and Manish Raja

Article Type: Review Article | First Published: June 28, 2018

Diabetes mellitus (DM), a cluster of metabolic diseases, resulting in high blood glucose levels, is prevalent in today's world. The global costs of diabetes and its consequences are rising and are expected substantially increase by 2030, especially in middle- and lower-income countries. Evidence-based therapies, specifically targeting the reduction of high blood glucose levels, and minimizing diabetic complications, are currently the choice of treatment. Stem cell therapy offers a promising visi...

 Open Access DOI:10.23937/2469-570X/1410052

Allogeneic Hematopoietic Stem Cell Transplant (Hsct) in Mantle Cell Lymphoma: 4 Years of Complete Remission

David Cavalcanti Ferreira, Marcio Ribeiro de Andrade Filho, Fabio Rodrigues Kerbauy and Jose Salvador Rodrigues de Oliveira

Article Type: Case Report | First Published: May 30, 2018

According to the World Health Organization, the mantle cell lymphoma is a lymphoma subtype characterized by the translocation t (11;14) resulting in overexpression of the protein cyclin D1+. The clinical presentation typically includes extranodal, particularly bone marrow and gastrointestinal tract. Of all B cell lymphomas, it has the worst prognosis and survival, around 3 to 5 years....

 Open Access DOI:10.23937/2469-570X/1410051

Reconstructing Mammalian Retinal Tissue: Wnt3a Regulates Laminar Polarity in Retinal Spheroids from Neonatal Mongolian Rats, while RPE Promotes Cell Differentiation

Matthias Rieke, Afrim Bytyqi, Florian Frohns and Paul G Layer

Article Type: Original Article | First Published: April 25, 2018

Besides invention of iPSC technology, recent progress of stem cell-based organoids is founded on long-standing 3D-reaggregate approaches from embryonic tissues. In particular, histotypic in vitro reconstruction of avian retinal spheroids was most prolific. For instance, a complete reconstitution of all retinal layers was possible, which was supported by Wnt signalling and factors from the retinal pigmented epithelium (RPE); similar in vitro findings are still missing for mammals. Using an establ...

Volume 5
Issue 1