Current Status and Future Prospects of Idebenone in Treatment of Mitochondrial Diseases: Literature Review
Hendi Maher, MD, Weiwei Zhang, Ke Chen, MD, Henry Davies and Xiujun Cai, MD
Article Type: Review Article | First Published: June 15, 2019
Idebenone (IDBN) is an antioxidant compound, structurally related to coenzyme Q10. It's therapeutic potential is growing in different areas. Over the two decades ago, for potential treatments of mitochondrial diseases have been suggested, relatively few have undergone controlled clinical trials. This review focuses on the recent history of manuscripts of idebenone, coenzyme Q10 and exercise in both primary disorders and secondary disorders. Despite prior clinical impressions that IDBN had a posi...
Vertebral Endplate, Posterior Ligamentous Complex and Neural Dysfunction: Key Factors for Posterior Fusion Strategy in Thoracolumbar Fractures
Mingyong Liu, Liang Zhang, Liangmin Zhang, Jianhua Zhao, Peng Liu, W Fan, X Ying and Y Liu
Article Type: Research Article | First Published: May 25, 2019
The thoracolumbar region (T11 to L2) is more susceptible to injury than other parts of the spine. Approximately 50% of all vertebral body fractures and 40% of all spinal cord injuries occur from T11 to L2. Although basic principles of diagnosis and treatment are established, there are controversies concerning diagnosis and treatment, including classification, indications for surgery and approach, as well as long-or short-segment of fixation and fusion....
Role of Laparoscopy in Abdominal Trauma
Ala Wafa, Mustafa Elsagier, Rawad Friwan and Abdulaziz Baio
Article Type: Original Article | First Published: April 27, 2019
The role of laparoscopy in abdominal trauma has increased in the last years in diagnosis as well as therapeutic interventions. It is a viable alternative for the diagnosis of intra-abdominal injury in both penetrating and blunt trauma. The number of negative laparotomies decreased since the use of laparoscopy in trauma patients. A retrospective study of twenty eight patients with abdominal trauma (22 penetrating trauma, 6 blunt trauma) were laparoscopic intervention done by general surgery depar...
Management Outcome and Associated Factors of Surgically Treated Non Traumatic Acute Abdomen at Attat Hospital, Gurage Zone, Ethiopia
Tekalign Admasu Gebrie, Tilahun Beyene Handiso and Shemsu Nuriye Hagisso
Article Type: Original Article | First Published: April 17, 2019
Non traumatic acute abdomen is an acute onset of abdominal disease entities that require immediate surgical intervention in most of the cases. The causes of non-traumatic surgical acute abdomen and their relative incidence vary in different populations. The aim of this study was to assess the management outcome and associated factors of surgically treated non-traumatic acute abdomen. Hospital-based prospective cross sectional study was conducted on surgically treated non-traumatic acute abdomen ...