Open Access DOI:10.23937/2572-4045.1510015
Total Pancreatectomy and Islet Auto-Transplantation in Children with Chronic Pancreatitis
Megan Berger, Melena Bellin, Sarah Jane Schwarzenberg and Srinath Chinnakotla
Article Type: Review Article | First Published: December 19, 2015
Chronic pancreatitis (CP) is an uncommon diagnosis in children, with an estimated incidence of fewer than 0.5 cases per 100,000 in patients younger than 25 years. Chronic pancreatitis in children most commonly results from genetic mutations, including mutations in the PRSS1, SPINK1, and CFTR genes. A recent multinational cross-sectional study of children with chronic pancreatitis demonstrated genetic etiology in upwards of 67% of cases while obstructive etiology including biliary calculi and con...
Open Access DOI:10.23937/2572-4045.1510014
Total Pancreatectomy and Islet Auto-Transplantation for Chronic Painful Pancreatitis: An Overview
Megan Berger, Gregory J Beilman, Ty Dunn, David Sutherland and Srinath Chinnakotla
Article Type: Review Article | First Published: December 02, 2015
Chronic pancreatitis is a progressive and irreversible process that can lead to pain, pancreatic dysfunction, and even malignancy. Management can be difficult, with some patients proving refractory to standard medical or endoscopic treatments. These patients generally depend on narcotics to manage their symptoms. Total pancreatectomy and Islet Auto-Transplantation (TP-IAT) can offer relief for such patients by removing the root cause of their pain. The pancreas is entirely resected and islets ar...
Open Access DOI:10.23937/2572-4045.1510013
The Impact of Renal Transplantation on Lower Limb Perfusion
Paul Alexander, Emma Aitken, David Mansouri and David Kingsmore
Article Type: Research Article | First Published: November 25, 2015
The benefits of renal transplantation are now more accessible to older, more comorbid patients. Currently, those with peripheral vascular disease are often excluded partly due to the theoretical risk of post transplantation limb ischemia, where blood is diverted away from an already under-perfused leg. This study aims to determine if renal transplantation affects lower limb perfusion....
Open Access DOI:10.23937/2572-4045.1510012
Infection after Pediatric Living Related Liver Transplantation: Timing, Types and Risk Factors
Behairy El-Sayed Behairy, Hatem Abdel-Sattar Konsowa, Haidy Mohammed Zakaria, Osama Hegazy Abd-Elsalam and Mostafa Mohamed Sira
Article Type: Research Article | First Published: November 16, 2015
The study was a retrospective cohort. It included 27 pediatric patients underwent liver transplantation (LTx). All patients' records were reviewed. A wide range of potential risk factors for infection and post-transplant complications were recorded. Follow-up data were collected for 1.5 years post-transplant, every infection attack during this period were subjected to detailed risk analysis....
Open Access DOI:10.23937/2572-4045.1510011
Management of Bipolar Disorder in Liver Transplantation: A Single Center Experience
Humberto C Gonzalez, Paige E Morgan, Sheila Jowsey, Laura J Myhre, Adriana Vasquez and Kymberly D Watt
Article Type: Research Article | First Published: November 09, 2015
Bipolar disorder and end stage liver disease commonly intersect and their management may include evaluation for liver transplantation. Psychiatric illness may impair adherence to medical regimens jeopardizing the allograft, thus, generating divided opinions by liver transplant selection committees whether transplantation is even possible in this scenario. There is very limited data about the optimal management of bipolar disorder before and after liver transplantation. We analyze a case series o...
Open Access DOI:10.23937/2572-4045.1510010
A Complicated Case of Transplant Renal Artery Stenosis: A Case Report and Literature Review
Gregor Mlinsek, Alexander Jerman, Damjan Kovac, Jelka Lindic, Miro Mihelic, Nikola Lakic, Aljosa Kandus and Jernej Pajek
Article Type: Case Report | First Published: October 22, 2015
Transplant renal artery stenosis (TRAS) is a well recognized complication of kidney transplantation. Hypertension with or without an increasing creatinine level is the most common presentation. Recognition of TRAS is important because it represents a potentially reversible cause of hypertension, allograft loss and adverse patient outcome. Here we report a demanding case of TRAS in a kidney transplant recipient who received a pediatric kidney. The complicated course included conservative therapy,...
Open Access DOI:10.23937/2572-4045.1510009
Could Accidental Ischemic Attacks Protect Against Subsequent Ischemic Reperfusion Injury?
Mohamed S. A. Mohamed
Article Type: Retrospective Study | First Published: August 20, 2015
Heart failure is the end result of various cardiac diseases that might be of ischemic or non-ischemic etiology. Implantation of ventricular assisting devices has been introduced as a bridge to heart transplantation, when heart failure reaches a critical degree of decompensation. The ischemic background of heart failure was suggested to have a protective effect in comparison to the non-ischemic background, based on the principles of ischemic conditioning....
Open Access DOI:10.23937/2572-4045.1510008
Stem Cell Transplantation to Treat Severe Refractory Multiple Sclerosis
Athanasia Mouzaki, Marios I Garyfallou and Kokona Chatzantoni
Article Type: Review Article | First Published: August 13, 2015
In severe, drug-resistant Multiple Sclerosis (MS), Stem Cell Transplantation (SCT) was introduced as a treatment option about 20 years ago. Application of autologous SCT is based on the assumption that MS is not inherited in a Mendelian fashion and the auto reactive immune system can be replaced by a healthy one. Allogeneic SCT ensures that all leukocytes are of donor origin, but is applied rarely. Both approaches are fraught with problems resulting, mainly, from the high-intensity pre-transplan...
Open Access DOI:10.23937/2572-4045.1510007
Impact of Donor Cytomegalovirus Serology and duration of Prophylaxis on Follow-Up Strategy in Lung Transplant Recipients
Jose M. Borro, Maria Delgado, Teresa Rey and Pablo Rama
Article Type: Original Article | First Published: July 04, 2015
Cytomegalovirus (CMV) infection is the most prevalent opportunistic infection after lung transplantation. It is reported in between 20% and 50% of cases after discontinuation of prophylaxis, depending on the series. CMV usually remains dormant in the lymphatic system, and its reactivation, due to immunosuppressive therapy, may have considerable adverse consequences in the immunocompromised host. Its many and varied effects include inflammation, increased morbidity, and decreased graft and patien...
