Liver Transplantation for Budd Chiari Syndrome: Survival Outcomes in a South African Centre- A 10-year Experience
Asila Abdelatif, Geoffrey Candy and Russell Britz
Article Type: Original Research | First Published: June 07, 2021
Budd Chiari syndrome (BCS) provides a unique and complex challenge to transplant surgeons. Single centre data is scare and there is no published data on orthotropic liver transplantation (OLT) for BCS from a single centre in an African setting. The aim was to retrospectively review all patients with BCS who received an OLT in our unit, comparing survival outcomes with matched liver transplant recipients, identifying the underlying thrombotic pathology and the post-transplant morbidities related ...
Simultaneous Pancreas-Kidney Transplantation: A Regional Transplant Center Analysis
Tiago Isidoro Duarte, Joana Marques, Nuno Germano, Francisco Remedio, Jorge Paulino, Américo Martins, Aníbal Ferreira and Fernando Nolasco
Article Type: Brief Report | First Published: May 27, 2021
Pancreas graft thrombosis following simultaneous pancreas-kidney transplantation is the leading non-immunologic cause of graft loss. Although essential to prevention of thrombotic failure of the new graft, systemic anticoagulation is controversial as it may lead to an increased risk of postoperative life threatening bleeding. A total of 35 simultaneous pancreas-kidney transplants were performed in our Transplant Centre between 2018 and 2020. Patients were divided in two retrospective cohorts acc...
Association of Calculated Area under the Curve or Cyclosporine C0 and C2 Level Monitoring in Pediatric Renal Transplant Patients
Kaan Savas Gulleroglu, Esra Baskin, Aydincan Akdur, Gokhan Moray and Mehmet Haberal
Article Type: Research Paper | First Published: April 24, 2021
Cyclosporine A (CsA) is highly variable pharmacokinetically and has a narrow therapeutic window; the serum level of patients treated with CsA must be monitored carefully. We investigated the trough and second-hour serum levels of CsA, the calculated area under the curve (AUC), and their association of those factors with chronic allograft dysfunction in pediatric patients. Fifteen renal allograft recipients (8 boys and 7 girls; mean age, 15.2 ± 3.5 years) who were undergoing treatment with cyclo...
Predictors of Graft Outcome in Renal Transplant Recipients with Antibody-Mediated Rejection
Ergün Parmaksız, Meral Meşe, Kübra Aydın Bahat and Serap Yadigar
Article Type: Research Paper | First Published: April 21, 2021
Active and chronic antibody-mediated rejection (AMR) is a common cause of graft failure. Prognostic markers of this complication are not well defined. We aimed to find out the demographic, histopathological and clinical characteristics of transplant recipients who developed AMR and to evaluate the impact of these features as well as antirejection treatment modalities on graft survival. Thirty -two patients who developed AMR (22 male; mean age 40.59 ± 12.52 years) were included in the study. Da...
Validation of Cardio-Emulation Pump Perfused, Porcine Liver Model: Blood Flow Response to Temperature
Gerond Lake-Bakaar, MD, PhD, Charles Aardema and John Robertson VMD, PhD
Article Type: Original Article | First Published: March 31, 2021
The liver is unique in possessing a dual blood supply. It receives approximately 80 percent of flow from the portal vein and the rest from the hepatic artery. Thus, the hepatic microvasculature receives blood from two types of afferent vessels: Portal venules and hepatic arterioles. The portal venules directly connect with the sinusoids to supply the liver parenchyma with blood rich in nutrients, but at low oxygen tension. The hepatic arterial system is not just supplementary to the portal vein....
Laparoscopic Right Donor Nephrectomy with Complete Left Sided Inferior Vena Cava: Rare Case Report
Prashant Kumar, Sachin Joseph and Kiran S Nair
Article Type: Case Report | First Published: January 30, 2021
Vascular anomalies is associated with increased complexity and complication during live donor nephrectomy. We hereby report a right transperitoneal laparoscopic nephrectomy done in donor with complete left sided IVC (LIVC). Preoperative evaluation by CT Angiography clearly demonstrated venous anomaly. In view of long right renal vein, right laparoscopic donor nephrectomy was performed. Length was sufficient for anastomosis in recipient. Recipient’s serum creatinine was 1.2 mg/dl on 5th postope...