Oral Health Care to HIV-Infected Children
Gerardo Rivera Silva and Hector R Martinez Menchaca
Article Type: Commentary | First Published: June 25, 2015
The prevalence of oral lesions in human immunodeficiency virus (HIV)-infected children in developed countries is equivalent to 72%, meanwhile in developing countries it equates to 60%. For this reason health professionals should identify and treat the numerous oral manifestations in HIV-infected children. There are several oral lesions that could be present in HIV-infected children....
Liver Fibrosis in HIV and HCV Co-Infection: Independent Mechanisms versus Collective Efforts
Jose D Debes, Paul R Bohjanen and Andre Boonstra
Article Type: Review Article | First Published: May 27, 2015
Liver disease is the leading cause of death not related to AIDS in patients infected with human Immunodeficiency Virus (HIV). Patients co-infected with HIV and hepatitis C virus (HCV) experience a more rapid progression liver to fibrosis and develop hepatocellular carcinoma at a younger age than those infected with either virus alone. The mechanisms promoting this accelerated progression to fibrosis are not totally understood. Moreover, it is unclear whether both viruses exert fibrosis progressi...
T-reg are the Predominant CD4+ T-Cell Subset Productively Infected with HIV-1 at Sites of Dual HIV/TB Infection
Christina S Hirsch, Shigou Liu, Joy Baseke, John Lusiba Kafuluma, Mary Nserko, Harriet Mayanja-Kizza and Zahra Toossi
Article Type: Research Article | First Published: February 10, 2015
Background: Regulatory T-cells (T-reg) are expanded during active tuberculosis (TB) regardless of HIV-1-infection, particularly at sites of M. tuberculosis infection. In HIV-1 disease, T-reg are targeted by HIV-1 infection. However, whether they contribute to promotion of HIV-1 infection at sites of HIV/TB is unknown. Methods: Pleural fluid mononuclear cells (PFMC) from HIV/TB patients with pleural TB were characterized by immunostaining and FACS analysis for surface markers CD4, CD127, CCR5, CX...