Sequence and Expression Analysis of Procine GLI3 gene
Ying Wang, Zhengwei Zhang, Yifan Dai and Haiyuan Yang
Article Type: Research Article | First Published: October 11, 2017
GLI family zinc finger 3 (GLI3) has been shown to play a critical role in the regulation of Hedgehog signaling, with important implications in embryonic and postnatal development. However, the molecular characteristics of GLI3 gene and its expression profile in pig tissues have yet to be elucidated....
Thermo Stability of DNA Methylation Marks in Human Sperm
Timothy G Jenkins, Monis B Shamsi, Emma James, Kenneth I Aston and Douglas T Carrell
Article Type: Research Article | First Published: June 12, 2017
Shipping of various tissues, including sperm, for the purposes of diagnostic testing and/or collaborative scientific pursuits is commonly performed. While many sample attributes are largely stable during the shipping process regardless of shipping environment, some physical factors such as temperature, duration of storage and other handling conditions may affect certain features of these samples including a commonly assessed epigenetic mark, DNA methylation....
Testing the Mutagenicity Potential of Chemicals
Geert R Verheyen, Koen Van Deun and Sabine Van Miert
Article Type: Research Article | First Published: May 15, 2017
All information for the proper development, functioning and reproduction of organisms is coded in the sequence of matched base-pairs of DNA. DNA mutations can result in harmful effects and play a role in genetic disorders and cancer. As mutations can arise through exposure to chemical substances, testing needs to be done on substances that humans and animals can be exposed to....