Preserved Left Ventricular Performance in Spontaneously Hypertensive Rats Following Preload and Afterload Challenges
Ming Fan, Mahmoud M. El-Mas, and Abdel A. Abdel-Rahman
Article Type: Original Research Article | First Published: August 29, 2015
Chronic LV pressure overload, e.g. in hypertension, leads to cardiac hypertrophy and ultimately heart failure. However, it is not clear if cardiac performance is compromised during early stages of LV hypertrophy before the development of heart failure. Studies in animals with LV hypertrophy revealed conflicting results due to differences in the magnitude, duration, and method of induction of cardiac hypertrophy as well as in the ventricular chamber involved....
Review of 2003 to 2015 Guidelines on Treatment of Hypertension in Patients with Coronary Artery Disease
Wilbert S. Aronow
Article Type: Review Article | First Published: July 18, 2015
Patients with coronary artery disease should have their modifiable coronary risk factors intensively treated. Dietary sodium should be reduced. Hypertension should be treated with beta blockers and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Long-acting nitrates are effective antianginal and antiischemic drugs. Calcium channel blockers may be added if angina persists despite beta blockers and long-acting nitrates....