Effects of Methotrexateonil-6alphar, VCAM-1 and NF Kappa B Expression in a Rat Model of Metabolic Syndrome
Nicolas F Renna, Jesica M Ramirez, Rodrigo D Garcia, Emiliano A Diez and Roberto M Miatello
Article Type: Research Article | First Published: December 17, 2016
Increasing evidence suggests that immune activation and inflammatory mediators may play a role in the development and progression of atherosclerosis. Several studies have shown that patients with some diseases characterized by inflammatory mediator activation, which rheumatoid arthritis (RA), presented accelerate atherosclerosis. RA is a systemic inflammatory disease and the most common cause of death is due to accelerated atherosclerosis, especially coronary artery disease....
Can Effective Treatment of Resistant and Uncontrolled Hypertension Improve Outcomes from Atrial Fibrillation Ablation?
Eysenck W and Sulke N
Article Type: Review Article | First Published: October 26, 2016
In recent years, there has been great interest in non-pharmacological methods to manage uncontrolled and resistant hypertension. Renal denervation and formation of a central iliac anastomosis are examples. In addition, renal denervation has yielded promising results in the prevention and treatment of AF. We have analysed the potential explanations for this in detail. A central iliac arteriovenous anastomosis, meanwhile, reduces arterial stiffness which is not targeted by sympathomodulation....
Intensive versus Standard Therapy for Hypertension: The Clinical Trials
Neal Shah, Nicolle M Siegart, Joshua De Leon and Allison B Reiss
Article Type: Review Article | First Published: October 19, 2016
Hypertension is the leading risk factor for premature death and disability. It can be controlled through lifestyle changes and use of antihypertensive medication. This review looks at intensive blood pressure reduction trials in non-diabetic, diabetic, and mixed patients' populations. The primary hypothesis for the Systolic Blood Pressure Intervention Trial (SPRINT) is that treating to a systolic blood pressure target of < 120 mmHg (the intensive intervention) compared to a systolic blood pressu...
Mineralocorticoid Receptor Blockade Lowers Blood Pressure and Improves Endothelial Function in Obese Patients with Metabolic Syndrome
Danielle GA Ezequiel, Frida Liane Plavnik, Monica B Costa, Julio CM Lovisi, Fernando AB Colugnati, Juliana Machado Saraiva and Rogerio B de Paula
Article Type: Original Article | First Published: October 17, 2016
Introduction: Aldosterone has been implicated in the pathophysiology of both metabolic syndrome (MS) and MS-associated arterial hypertension, despite the use of mineralocorticoid receptor antagonists in these scenarios has been little studied. Objectives: To assess the effects of mineralocorticoid blockade on blood pressure as well as metabolic and renal parameters in mild hypertensive subjects with MS compared with an active control group....
Advances in Low-Dimensional Mathematical Modeling of the Human Cardiovascular System
S Malatos, A Raptis and M Xenos
Article Type: Review Article | First Published: September 22, 2016
The mathematical modeling of blood flow in the cardiovascular system has long history. Zero-dimensional (0D) and one-dimensional (1D) models contribute actively to the study of the human cardiovascular system. Usually, low-dimensional models consist of a system of time dependent equations that do not involve spatial derivatives, thus reducing the computational complexity compared to multi-dimensional models. Despite that more complex 3D cardiovascular models are available, there is a tendency of...
MyHEART: A Non Randomized Feasibility Study of a Young Adult Hypertension Intervention
Heather M Johnson, Jamie N LaMantia, Ryan C Warner, Nancy Pandhi, Christie M Bartels, Maureen A Smith and Diane R Lauver
Article Type: Original Research | First Published: September 12, 2016
In the United States, young adults (18-39 year-olds) have the lowest hypertension control rates (35%) compared to middle-aged (58%) and older (54%) adults. Ambulatory care for hypertension management often focuses on medication with little time for self-management and behavioral counseling. This study was designed to evaluate the feasibility of MyHEART, a telephone-based health coach self-management intervention for young adults....
Angiotensin-Converting Enzyme Inhibitor-Induced Cough Prevalence in Refractory Hypertensive Patients
Andre Nascimento Publio Pereira, Roque Aras Junior, Cristiano Ricardo Bastos Macedo, Ricardo Ribeiro do Nascimento Teixeira, Iuri Reseda Magalhaes, Diego Sant'ana Sondre, Bianca de Almeida Nunes and Juliana Queiroz Vasconcelos Muniz
Article Type: Original Article | First Published: August 18, 2016
Refractory Arterial Hypertension (RAH) is characterized by persistently high blood pressure values. Angiotensin Converting Enzyme (ACE) inhibitors in combination with other antihypertensive drugs are effective for RAH and have good clinical tolerance. According to the literature, the adverse effect of cough in patients using ACE inhibitors occurs in 5 to 20% of them. However, in clinical practice, the incidence appears to be higher, making it difficult the therapeutic adherence....