Distribution of Rotavirus Genotypes among Children with Diarrhea Prior to Vaccine Introduction in Western Kenya
John B Ochieng, Sammy Khagayi, Billy Ogwel, Reuben Onkoba, Evans Apondi, Jane Juma, Mapaseka Seheri, Ina Peenze, Clayton Onyango, Elizabeth Hunsperger, Collins Tabu, Sergon Kibet, Richard Omore, Frank Odhiambo, Jeffrey Mphahlele, Jennifer R Verani, Barry Fields, Godfrey Bigogo, Kayla F Laserson, Jacqueline E Tate, Jason M Mwenda and Robert F Breiman
Article Type: ORIGINAL RESEARCH ARTICLE | First Published: February 16, 2019
Group A rotavirus is the leading cause of diarrhea hospitalization among children worldwide. Most fatal rotavirus-associated diarrhea cases among children under 5 years occur in Africa and Asia. We investigated the molecular epidemiology of circulating rotavirus strains among children less than 5 years in western Kenya to provide baseline data on the prevalence of each genotype prior to the introduction of monovalent rotavirus vaccine in Kenya. From January 2010 to December 2013, stool samples w...
Impact of Rapid Microorganism Identification Using Two Multiplex PCR Platforms on Timing of Antimicrobial Therapy
Natasha N Pettit, Zhe Han, Angella Charnot-Katsikas, Jennifer Pisano and Vera Tesic
Article Type: Research Article | First Published: February 11, 2019
Strategies to improve time to administration of appropriate, effective antimicrobial therapy can improve patient outcomes. We sought to retrospectively assess if the earlier identification of blood pathogens and their resistance determinants with multiplex PCR platforms could have an impact on time to initiate appropriate antimicrobial therapy. All patients with monomicrobial positive blood cultures from March to June 2013 were included in the retrospective chart review analysis. We evaluated th...
High Prevalence of Hepatitis B Virus Infection among Pregnant Women Attending Antenatal Care in Central Nigeria
Peter Asaga Mac, Adamu Chipago Suleiman and Philomena Ehi Airiohuodion
Article Type: Original Research | First Published: January 30, 2019
A total of 200 pregnant women subjects were selected for this study to determine the sero-prevalence of hepatitis B virus (HBV) infection and assess the risk factors among pregnant women attending ante natal care at FMC, Keffi, Nigeria. A structured questionnaire was used for the data collection. Sera were collected and tested for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg). The sero prevalence of HBV infection and its infectivity is high in Central Nigeria. This resear...
Intraleukocytic Yeast Inclusions and Toxic Granulation Neutrophils on Peripheral Blood Smear: An Interesting Synergy between Hematology and Microbiology
Fabio Miglietta, Claudio Palumbo, Fernando Parente, Luciano Velardi, Rosella Matera, Luigi Conte, Michela Dargenio, Maurizio Quarta, Milva Maria Nuzzo, Nicola Di Renzo and Giambattista Lobreglio
Article Type: Case Report | First Published: January 18, 2019
The presence of yeast neutrophil inclusions was observed and discussed several times in other reports; moreover some works demonstrated how Toxic Granulation Neutrophils (TGNs) are especially helpful in predicting acute bacterial infection, while the development of candidaemia-related TGNs was rarely described and in-depth. We describe two occasional findings of neutrophil inclusions and marked TGNs respectively due to Candida tropicalis and Candida guillermondi on peripheral blood smear....
Profile of Pathologies Diagnosed in Patients Hospitalized in a Ward of Infectious Diseases at the Era of HIV in Bamako, Mali West Africa
Cissoko Y, Traore F, Dicko MS, Konate I, Sidibe AF, Dembele JP, Fongoro S and Dao S
Article Type: Research Article | First Published: January 16, 2019
Infectious diseases remain major public health issues with their corollary of epidemic and endemic disease, principally in developing countries. In 2010, the number of infections diseases related deaths was estimated to 15 millions per year worldwide and the World Health Organization (WHO) fore-casts this number to 13 million in 2050. These various infectious diseases, from the most frequent like malaria to the less like neglected tropical diseases are a scourge for developing countries and are ...
Cost-Effectiveness Analyses of Different Vaccination Strategies to Reduce Pertussis among Infants in Sweden
Ellen Wolff, Bernice Aronsson, Markus Hultstrand and Lisa Brouwers
Article Type: Original Article | First Published: January 09, 2019
Pertussis is a drawn-out and troublesome respiratory disease. Infants have a greater burden of disease than older children and adults, and are more likely to suffer complications. New vaccination strategies need to be considered to reduce pertussis among infants. The aim of the study was to evaluate cost-effectiveness of three alternative vaccination strategies, in comparison with current vaccination schedule....
Uncomplicated Malaria and Intestinal Helminth Co-Infections among Schoolchildren in Abobo District, Abidjan (Cote d'Ivoire)
Kpongbo Etienne Angora, Vincent Djohan, Abibatou Konate, Pulcherie Christiane Kiki-Barro, Akoua Valerie Bedia-Tanoh, Kondo Fulgence Kassi, Abo Henriette Vanga-Bosson, Sebastien Miezan, Eby Herve Menan and William Yavo
Article Type: Original Article | First Published: January 04, 2019
Malaria and soil-transmitted helminth infections are morbidity causes in most tropical areas in the world. In Côte d'Ivoire, their association greats a major public health problem and their coexistence is the subject of very few studies. The current study investigated uncomplicated malaria and intestinal helminths co-infection among schoolchildren in Abobo District, Abidjan. This cross-sectional study was conducted with 256 children aged 2 to 15 recruited at the Anonkoua - Kouté Urban and Comm...