Efficacy and Safety Assessment of Three Artemisinin- Based Combination Therapy (Acts) in the Treatment of P. falciparum Malaria in Cameroon
Theresia Njuabe Metoh, Roger Somo-Moyou, Philip Gah Fon, Ernest Tambo, Jun-Hu Chen and Zhou Xiao-Nong
Article Type: Research Article | First Published: December 31, 2021
Artemisinin-based Combination Therapies (ACTs), have been reported to be effective against multidrugresistant Plasmodium falciparum. There are controversies in the choice of the type of ACTs to be used at hospitals settings and health centers. This is mostly determined by the cost and less side effects reported for each drug leading to an over prescription and consumption of some ACTs compared to others and consequently to drug resistance. This situation highlight the importance for constant mon...
Post-Artesunate Delayed Hemolysis after Treatment of Malaria with Intravenous Artesunate: A Case Study
Article Type: Case Report | First Published: December 24, 2021
Delayed hemolysis is an uncommon reaction to intravenous artesunate for the treatment of severe malaria. We report a case of a patient who developed severe malaria after initial inadequate treatment, thus requiring IV artesunate therapy. Delayed hemolytic anemia then occurred and was monitored for weeks after completion of treatment. Malaria is a vector-borne infectious parasite that is transmitted through mosquitoes. It is a very prevalent disease globally, usually in areas of the world that ar...
Effects of Race on the Outcome of COVID-19 in Hospitalized Patients
Getahun Abate, Aniruddh Kapoor, Edward Charbek, Bryan Beck, Qian Wang, Grace C Wang, Mackenzie Steck, Jason Zoglman, Robin R Chamberland, Sharon Frey, Daniel F Hoft and Timothy L Wiemken
Article Type: Research Article | First Published: December 24, 2021
Recent reports indicate that African Americans have higher mortality rates from SARSCoV- 2 coronavirus disease 19 (COVID-19) compared to Caucasians, with more marked differences in the Midwest region of the US. This study was performed to study differences in COVID-19 related mortality and hospital length of stay (LOS) between African Americans and Caucasians in Midwest setting, and identify factors associated with mortality and LOS. Data were collected from the electronic health records (EHR) ...
An Accuracy-Based Approach to the Microbiologic Diagnosis of Pulmonary Infection: Part II
John Ferguson, MD, MPH, Cyprien Jungels, DO and Michael Gailey, DO
Article Type: Review Article | First Published: December 16, 2021
Similar to that of bacterial infection, the performance of diagnostic tests for endemic fungal pneumonia and opportunistic fungal pneumonia are uncertain. We undertook a literature search to assess the accuracy of diagnostic tests for pneumonia, identified through a search of MEDLINE-indexed journals. Sensitivity and specificity of diagnostic tests for pneumonia were calculated with respect to various reference standards. A combination of diagnostic testing is adequate to rule out most endemic f...