Performance of Hi-Flex Femoral Component in Total Knee Arthroplasty - A Randomized Control Study
Sheldon Moniz, Ryan Du Sart and Piers Yates
Article Type: Research Article | First Published: June 16, 2018
Total knee replacement (TKR) is a surgical procedure for intractable degenerative disease of the knee joint. Despite continued evolution in prosthesis design and surgical procedures, restricted range of motion and functional performance is still common in patients undergoing TKR. Posterior stabilized TKR aims to maintain a more reproducible roll back than cruciate retaining and mobile bearing knees, possibly leading to better flexion and function....
Carpometacarpal Boss with Extensor Tendon Rupture: Case Report
Ayesha Yahya and H Brent Bamberger
Article Type: Case Report | First Published: May 25, 2018
Carpometacarpal boss is a rare cause of pain and swelling on the dorsum of the hand. Literature is limited on the etiology of this condition and there is no consensus on treatment. We report an unusual case of a 53-year-old man with extensor tendon rupture caused by carpometacarpal boss. Surgical excision of the bony growth and repair of the EIP utilizing interpositional tendon autograft resulted in relief of symptoms and return of function....
Oral Ibuprofen Interferes with Cellular Healing Responses in a Murine Model of Achilles Tendinopathy
Adam Bitterman, Shuguang Gao, Sabah Rezvani, Jun Li, Katie J Sikes, John Sandy, Vincent Wang, Simon Lee, John Holmes, Johnny Lin and Anna Plaas
Article Type: Original Research | First Published: May 21, 2018
The attempted healing of tendon after acute injury (overloading, partial tear or complete rupture) proceeds via the normal wound healing cascade involving hemostasis, inflammation, matrix synthesis and matrix remodeling. Depending on the degree of trauma and the nature of the post-injury milieu, a variable degree of healing and recovery of function occurs....
Bisphosphonates and MeCP2 Deficiency: Cellular Studies and Clinical Application in Rett Syndrome
Jay R Shapiro and Mary E Blue
Article Type: Short Note | First Published: May 18, 2018
In this Short Note, we assess what is known about the structural deficits in bone in Rett syndrome (RTT), a rare x-linked neurodevelopmental disorder and in mouse models of RTT and provide a rationale for the treatment of bone fragility observed in this disorder. RTT is caused by mutations in a gene that encodes for methyl CpG protein binding protein 2 (MeCP2), which can act as an inhibitor or activator of gene transcription. MeCP2 is ubiquitously expressed throughout the body....