Outcome of Some of the Many Aedes Albopictus (Skuse, 1895) Mosquito Encounters with Man
Daniel Benharroch1* and Yane-Bianca Benharroch2
1Department of Pathology, Soroka University Medical Center, Israel
2Kibbutz Sde-Boker, Israel
*Corresponding author: Prof. Daniel Benharroch, Department of Pathology, Soroka University Medical Center, 1, Itshak Rager Boulevard, PO Box 151, Beer-Sheva 84101, Israel, Tel: +972-50-7579140, Fax: +972-8-6232770, E-mail: email@example.com
Clin Med Rev Case Rep, CMRCR-3-145, (Volume 3, Issue 12), Review Article; ISSN: 2378-3656
Received: October 19, 2016 | Accepted: November 29, 2016 | Published: December 03, 2016
Citation: Benharroch D, Yane-Bianca B (2016) Outcome of Some of the Many Aedes Albopictus (Skuse, 1895) Mosquito Encounters with Man. Clin Med Rev Case Rep 3:145. 10.23937/2378-3656/1410145
Copyright: © 2016 Benharroch D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aedes albopictus, the Asian tiger mosquito, has lately become prominent, globally, while showing a marked "migratory" capacity. We have scrutinized the many consequences of the encounters between the Asian tiger mosquito and humans, and have chosen to review several of them. It seems inevitable that this mosquito be more and more present in our lives. It is a tremendous nuisance to man through its bite. However, several arboviral infections are the main consequences of these confrontations, encompassing all ranges of severity. Few means of prevention, however, have proven successful.
Aedes albopictus, Asian tiger mosquito, Arboviral infections, Chikungunya, Dengue, Yellow fever
The Asian tiger mosquito, the Aedes albopictus (Ae. albopictus) (Skuse, 1895) (Diptera: Culicidae) originates, as expected from its current name from the Far East. Its "tiger" surname was given to it, due to white dots on its legs and white bands on its body. Although a small insect, usually less than one centimeter in length, the Ae. albopictus is a huge nuisance to mammals and especially to man, but it has been considered to feed also, to some extent on birds. It seems that foraging by the female Ae. albopictus, occurring during day light hours, is for the least, unpredictable.
The Asian tiger mosquito flies no more than 100-200 m at one time. Nevertheless, it is one of the most invasive of mosquitoes, being today widespread to most areas of the globe. Its spreading capacity is basically of a passive nature, as by proliferating in small water collections in old tires. The Asian tiger mosquito has been responsible, among many others, for the propagation of two arboviral infections, chikungunya and dengue. It seems that for both these viral infections, Aedes egypti, predominates as a vector over Ae. albopictus. It is generally agreed upon that the Asian tiger mosquito plays little or no role in the malaria and the West Nile virus fever pathogenesis.
In this text, we present an overview of particular facets of the interaction between the Ae. albopictus and humans, while a fierce migration of the insect is taking place.
Aedes Albopictus (Skuse, 1895)
The Ae. albopictus has progressively invaded temperate regions of Europe and of the Americas. The mosquito is the cause of severe nuisance and may transmit several arboviral infections. Its capacity to harm humans may be related with the age of the insect, irrespective of its physiological status . So far, European countries confirm that the most frequent arboviral diseases transmitted by the Ae. albopictus mosquito are due to imported cases [2,3].
The introduction of Ae. albopictus into Southern Europe occurred around the 1980s . By now, the Asian tiger mosquito has been identified as one of the fastest spreading of all and one of the world's worst invasive alien species [5,6]. An increased colonization of urban areas in Europe, related with a preference with the Ae. albopictus for shaded areas has been observed . The anthropophilism of the Ae. albopictus is maximal in high density urban areas and decreases progressively with increasing vegetation. The "migratory" propensity of Ae. albopictus, being in fact more of a passive process, together with its being a vector for several arboviruses, determines its transformation into a severe public health hazard .
Aedes albopictus was found in Israel to breed in tree holes adequately shaped to retain water for long enough periods . Among the many attractant products for the Asian tiger mosquito, an interesting one has been found to be the carob seed pod, which represents a rich source of sugar for the mosquito .
The Ae. albopictus is believed to be ubiquitous, mainly foraging on mammals, mostly humans, but only very occasionally on birds. A recent study did not find evidence of avian-related blood among 165 blood meals detected in the Asian tiger mosquito . This might preclude dissemination of the Ae. albopictus by bird migration. Female Ae. aegypti which are also invasive, showed feeding inhibition, both for sugar and blood, when exposed to male Ae. albopictus. In contrast, the female Asian tiger mosquito foraging did not suffer from exposure to males of either species. This may be one important mechanism of displacement of Ae. aegypti by the Asian tiger mosquito .
High temperature and poor feeding during development of mosquitoes will usually result in small adults. The frequency of blood meals and of host seeking is inversely correlated with body size for the Ae. albopictus. This results in small mosquitoes having more contacts with the host . A marked increase in a large variety of mosquito species is occurring in Europe and the USA. Many of them belong to the same invasive species as the Asian tiger mosquito.
Arboviral Infectious Diseases
Dengue and chikungunya
These two mosquito-borne viral diseases are spreading persistently around the globe. Dengue, a frequent febrile illness in the tropical areas of Africa, is now disseminated to the Americas and this encompasses all the four serotypes of the dengue virus. This disease has also reached areas in Southern Europe during the summer .
Dengue belongs to the Flavivirus group of zoonoses, together with yellow fever and Zika fever. Their transmission includes primates as reservoirs and Aedes mosquitoes as vectors. However, human-to-human transmission has also been reported . As a rule, dengue is a mild acute febrile disease and may present with headache and myalgia (now defined as "dengue"). In some cases, more frequently in children, the disease will present with abdominal pain, lethargy, bleeding, hepatomegaly and thrombocytopenia. These symptoms and signs herald a severe development, often lethal ("severe dengue") . All ranges of hepatotoxicity may be found .
The chikungunya virus, originating from Central Africa (isolated cases and small outbreaks) or from Asia (large epidemics), has disseminated recently, first to islands of the Indian Ocean, then, to the Indian Subcontinent and to Italy. Last, it has reached the American continent, via the Caribbean.
Aedes aegypti predominates as the vector of both viruses. However, Ae. albopictus catches up rapidly, promoting their spread in temperate climate. Among the main factors fostering the spread of both viruses, are improved viral fitness, changes in global climate and increased urbanization .
Chikungunya is a rapidly emerging arboviral disease caused by an Alphavirus of the Togaviridae family. The patient temperature rises rapidly, accompanied by a symetrical arthralgia and often by extreme fatigue. Relapses are frequent. Currently, this infectious disease is being reported globally .
Yellow fever is caused by a Flavividae arbovirus, transmitted by Aedes mosquitoes. This has occurred mainly in Africa. In Central Africa, Ae. aegypti is the main vector of yellow fever in urban areas. However, Ae. albopictus is also significantly involved . On the other hand, one of the main factors why yellow fever and dengue coexist in some parts of the world (Africa), but not in others (Asia): in Africa, Ae. albopictus which competes with Ae. aegypti, shows a relatively low prevalence. While the Asian variant of Ae. aegypti is to some degree incompetent in transmitting yellow fever . Nevertheless, Ae. albopictus has largely replaced Ae. aegypti in Europe  and in the Americas .
The Zika virus had been isolated in several genera of mosquitoes and in non-human primates of the African and Asian forests for many years. However, recently reported epidemics, starting from Micronesia in 2015 and reaching the Northeastern areas of Brazil, Central America and the Caribbean have occurred. It is transmitted by infested Ae. aegypti and Ae. albopictus . Isolated cases imported from Polynesia were described in Italy.
The clinical picture includes low grade fever, malaise, conjunctivitis, myalgia, arthralgia and lymphadenopthy. In these cases, the sera are diagnostic and show a cross-reactivity with dengue virus antigens. In this study, the vector was most frequently the Ae. albopictus . This association was confirmed in recent Zika fever cases from Gabon, highlighting the presence of the Asian tiger mosquito in Africa . In the last several few months, involvement of the Zika virus in complications of the contamination of pregnant women in Venezuela and Brazil has been reported. These women gave birth to new born babies with congenital malformations, mainly microcephaly and with failure to thrive .
La crosse encephalitis
This is one of the most frequent causes of pediatric arboviral encephalitis in the USA. First described in Tennessee in 1997, it is transmitted, in addition to autochthonous vectors (Ae. triseriatus), by Ae. albopictus and Ae. Japonicus [27,28].
Several species of microfilaria are transmitted by mosquitoes. Dirofilaria species are transmitted by mosquito bites and may cause the human pulmonary as well as several others lesions. The Asian tiger mosquito may plays an important role in this contamination [29-32].
Malaria and west nile virus fever
Nevertheless, as the Asian tiger mosquito invades Africa and in fact, the world, these statements may be altered.
Immunology of asian tiger mosquito
Using appropriate antibodies against Ae. albopictus salivary proteins, which reveal a strong antigenicity, allergic reactions occur, regardless of the means of exposure. Near 70% of these proteins are related with blood feeding, including adenosine deaminase and serpin .
Skin reactions are observed following mosquito bites which vary from the relatively innocuous mosquito allergy, due to reactions to the allergens in the mosquito saliva. This may include severe local, and at times systemic reactions to the bite .
On the other hand hypersensitivity to the mosquito bite, which is one form of the chronic active infections by Epstein-Barr virus (EBV) may be observed. This rare condition, affecting predominantly children and young adults, evokes, in addition to a severe local skin reaction, generalized symptoms, like high fever and regional lymphadenopathy, hepatosplenomegaly, and is sometimes associated with hematological malignancies [40-43]. This reaction may be due to an antigen-induced activation of basophils or mast cells by a mosquito associated IgE.
Unlike mosquito allergy which is an immediate allergic skin reaction, IgE-dependent, hypersensitivity to mosquito bites causes severe symptoms resulting probably from mosquito-related CD4+ T cells and EBV-infected NK cells .
Aedes albopictus (Skuse, 1895) (Diptera: Culicida) presents several peculiarities, the most striking being a "migratory" capacity, rarely equaled but in fact a passive process. In addition the Ae. albopictus may lay its eggs in small pockets of water, as in used tires or hollow trees. Redistribution of the tires may promote dissemination. The mosquito causes a severe nuisance, but most arboviral infectious diseases carried by this species, are more critical, though of variable severity. This mosquito's bite, like that of many others, may cause a simple mosquito allergy and in a minority of victims, hypersensitivity to mosquito bites, which is associated with EBV infection, a severe local and systemic reaction and at times with hematological malignancies.
We thank Kibbutz Sde-Boker for their help during the preparation of this manuscript.
Conflict of Interest
The authors have declared: "that no conflict of interest exists".
Iovinella I, Caputo B, Michelucci E, Dani FR, della Torre A (2015) Candidate biomarkers for mosquito age-grading identified by label-free quantitative analysis of protein expression in Aedes albopictus females. J Proteomics 128: 272-279.
Valerio L, Roure S, Fernandez-Rivas G, Ballesteros AL, Ruiz J, et al. (2015) Arboviral infection diagnosed in European areas colonized by Aedes albopictus. Travel Med Infect Dis 13: 415-421.
Dinu S, Panculescu-Gatej IR, Florescu SA, Popescu CP, Sîrbu A, et al. (2015) Molecular epidemiology of dengue fever cases imported into Romania, 2008-2013. Travel Med Infect Dis 13: 69-73.
Marini F, Caputo B, Pombi M, Tarsitani G, della Torre A (2010) Study of Aedes albopictus dispersal in Rome, Italy, using sticky traps in mark-release-recapture experiments. Med Vet Entomol 24: 361-368.
Boes KE, Ribeiro JM, Wong A, Harrington LC, Wolfner MF, et al. (2014) Identification and characterization of seminal fluid proteins in the Asian tiger mosquito, Aedes albopictus. PLoS Negl Trop Dis 8: e2946.
Martinez-de la Puente J, Munoz J, Capelli G, Montarsi F, Soriguer R, et al. (2015) Avian malaria last supper: identifying encounters between parasites and the invasive Asian mosquito tiger and native mosquito species in Italy. Malar J 14: 32.
Cianci D, Hartemink N, Zeimes CB, Vanwambeke SO, Ienco A, et al. (2015) High resolution spatial analysis of habitat preference of Aedes albopictus in urban environment. J Med Entomol 52: 329-335.
Bonizzoni M, Gasperi G, Chen X, James AA (2013) The invasive mosquito species Aedes albopictus: current knowledge and future perspectives. Trends Parasitol 29: 460-468.
Muller GC, Kravchenko VD, Junnila A, Schlein Y (2012) Tree-hole breeding mosquitoes in Israel. J Vector Ecol 37: 102-109.
Muller GC, Xue RD, Schlein Y (2010) Seed pods of the carob tree Ceratonia siliqua are a favored sugar source for the mosquito Aedes albopictus in coastal Israel. Acta Trop 116: 235-239.
Faraji A, Egizi A, Fonseca DM, Unlu I, Crepeau T, et al. (2014) Comparative host feeding patterns of the Asian tiger mosquito, Aedes albopictus, in urban and suburban Northeastern USA and implication for disease transmission. PLoS Negl Trop Dis 8: e3037.
Soghigian J, Gibbs K, Stanton A, Kaiser R, Livdahl T (2015) Sexual harassment and feeding inhibition between two invasive dengue vectors. Environ Health Insights 8: 61-66.
Farjana T, Tuno N (2013) Multiple blood feeding and host-seeking behavior in Aedes aegypti and Aedes albopictus (Diptera: Culicidae). J Med Entomol 50: 838-846.
Rezza G (2014) Dengue and chikungunya: long distance spread and outbreak in naive areas. Pathog Glob Health 108: 349-355.
Choumet V, Depres P (2015) Dengue and other flavivirus infections. Rev Sci Tech 34: 473-478.
Wakimoto MD, Camacho LA, Guaraldo L, Damasceno LS, Brasil P (2015) Dengue in children: a systematic review of clinical and laboratory factors associated with severity. Expert Rev Anti Infect Ther 13: 1441-1456.
Prommalikit O, Thisyakorn U (2015) Dengue virus virulence and disease severity. Southeast Asian Trop Med Public Health 46: 35-42.
Burnett MW (2014) Chikungunya. J Spec Oper Med 14: 129-130.
Ngoagouni C, Kamgang B, Manirakiza A, Nangouma A, Paupy C, et al. (2012) Entomologic profile of yellow fever epidemics in the Central African Republic, 2006-2010. Parasit Vectors 5: 175.
Amaku M, Coutinho FA, Massad E (2011) Why dengue and yellow fever coexist in some areas of the world and not in others? Biosystems 106: 111-120.
Reiter P (2010) Yellow fever and dengue: a threat to Europe. Euro Surveill 15: 19509.
Luorenço de Olivera R, Vazeille M, de Filippis AM, Failloux AB (2003) Large genetic differentiation and low variation in vector competence for dengue and yellow fever viruses of Aedes albopictus from Brazil, the United States and the Cayman Islands. Am J Trop Med Hyg 69: 105-114.
Marcondes CB, Ximenes MF (2015) Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes. Rev Soc Bras Med Trop 49: s0037.
Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, et al. (2015) Zika virus infection imported to Italy: clinical, immunological, virological findings, and public health implications. J Clin Virol 63: 32-35.
Grard G, Caron M, Mombo IM, Nkoghe D, Ondo SM, et al. (2014) Zika virus in Gabon - 2007: a new threat from Aedes albopictus. PLoS Negl Trop Dis 8: e2681.
Citil-Dogan A, Wayne S, Bauer S, Ogunyemi D, Kulkharni SK, et al. (2016) The Zika virus and pregnancy: evidence, management and prevention. J Matern Fetal Neonatal Med 7: 1-41.
Westby KM, Fritzen C, Paulsen D, Poindexter S, Moncayo AC (2015) La Crosse encephalitis virus infection in field-collected Aedes albopictus, Aedes Japonicus and Aedes triseriatus in Tennessee. Am J Mosq Control Assoc 31: 233-241.
Gerhardt RR, Gottfried KL, Apperson CS, Davis BS, Erwin PC, et al. (2001) First location of La Crosse virus from naturally infected Aedes albopictus. Emerg Infect Dis 7: 807-811.
Weaver SC, Reisen WK (2010) Present and future arboviral threats. Antiviral Res 85: 328-345.
Paras KL, O'Brien VA, Reiskind MH (2014) Comparison of the vector potential of different mosquito species for the transmission of heartworm, Dirofilaria immitis in rural and urban areas, in and around Stillwater, Oklahoma, USA. Med Vet Entomol Suppl 1: 60-67.
Genchi C, Rinaldi L, Mortarino M, Genchi M, Cringoli G (2009) Climate and Dirofilaria infection in Europe. Vet Parasitology 163: 286-292.
Cancrini G, Romi R, Gabrielli S, Toma L, DI Paolo M, et al. (2003) First finding of Dirofilaria repens in a natural population of Aedes albopictus. Med Vet Entomol 17: 448-451.
Ali WN, Ahmad R, Nor ZM, Ismail Z, Lim LH (2011) Population dynamics of adult mosquito in malaria endemic villages of Kuala Lipis, Pahang, Malaysia. Southeast Asian J Trop Med Public Health 42: 259-267.
Shaffner F, Medlock JM, Van Bortel W (2013) Public health significance of invasive mosquitoes in Europe. Clin Microbiol Infect 19: 685-692.
Guo S, Ling F, Hou J, Wang J, Fu G, et al. (2014) Mosquito surveillance revealed lagged effect of mosquito abundance on mosquito-borne disease transmission. PLoS One 9: e112975.
Haddad N, Mousson L, Vaseille M, Chamat S, Tayeh J, et al. (2012) Aedes albopictus in Lebanon, a potential risk of arbovirus outbreak. BMC Infect Dis 12: 300.
Ogden NH, Milka R, Caminade C, Gachon P (2014) Recent and projected future climatic suitability of North America for the Asian tiger mosquito, Aedes albopictus. Parasit Vectors 7: 532.
Doucoure S, Cornelie S, Patramool S, Mouchet F, Demettre E, et al. (2013) First screening of Aedes albopictus immunogenic salivary proteins. Insect Mol Biol 22: 411-423.
Peng Z, Simons FE (2007) Advances in mosquito allergy. Curr Opin Allergy Clin Immunol 7: 350-354.
- Chiu TM, Lin YM, Wang SC, Tsai YG (2016) Hypersensitivity to mosquito bites as the primary manifestation of an Epstein-Barr virus infection. J Microbiol Immunol Infect 49: 613-616.
Asada H (2007) Hypersensitivity to mosquito bites: a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy and oncogenesis. J Dermatol Sci 45: 153-160.
Tomita N, Kanamori H, Fujimaki K, Fujisawa S, Ishigatsubo Y (2004) Epstein-Barr virus associated extranodal NK/T-cell lymphoma following mosquito bites in an elderly patient without prior hypersensitivity. Leuk Lymphoma 45: 2153-2155.
Peng Z, Simons FE (2004) Mosquito allergy: immune mechanisms and recombinant salivary allergens. Int Arch Allergy Immunol 133: 198-209.
Sakakibara Y, Wada T, Muraoka M, Matsuda Y, Toma T, et al. (2015) Basophil activation by mosquito extracts in patients with hypersensitivity to mosquito bites. Cancer Science 106: 965-971.