Duodenal Malt Lymphoma Developed in 1 Year

Intestinal MALT lymphoma is a very rare neoplasm and there is limited data about clinical and pathological characteristics. They can become visible in a very short time. A 47-year-old woman was referred to our department because of epigastric pain. Gastroduodenoscopy revealed an irregular mucosal nodular lesion with ulceration extending from the bulb to the second portion of the duodenum. Endoscopic findings were normal about one year ago. The pathology spesiemens show that; duodenal biopsy revealed atypical lymphoid infiltration with centrocyte-like morphology; immunophenotypic investigation was positive for CD20(+) and negative for CD3 and CD10. In gastric biopsies Helicobacter pylori was positive. We successfully eradicated H. pylori but did not see signs of remission. Here in we report a case of duodenal MALT lymhoma that was visible in one year and was resistant to Helicobacter pylori eradication. *Corresponding author: Ferdane Sapmaz, MD, Department of Gastroenterology, Kecioren Research and Training Hospital, Ankara, 06380, Turkey, Tel: +90-505-3576184, Fax: +90-312-356-90-03 CASE REpoRt

Intestinal MALT lymphoma is a very rare neoplasm and there is limited data about clinical and pathological characteristics. They can become visible in a very short time. A 47-year-old woman was referred to our department because of epigastric pain. Gastroduodenoscopy revealed an irregular mucosal nodular lesion with ulceration extending from the bulb to the second portion of the duodenum. Endoscopic findings were normal about one year ago. The pathology spesiemens show that; duodenal biopsy revealed atypical lymphoid infiltration with centrocyte-like morphology; immunophenotypic investigation was positive for CD20(+) and negative for CD3 and CD10. In gastric biopsies Helicobacter pylori was positive. We successfully eradicated H. pylori but did not see signs of remission. Here in we report a case of duodenal MALT lymhoma that was visible in one year and was resistant to Helicobacter pylori eradication. Also the optimal treatment of duodenal MALT lymphomas has not been standardized yet. In duodenal lymphomas, there are contradictory outcomes of Helicobacter pylori treatment. In a few cases, it has been shown that duodenal MALT lymphoma can be treated with Helicobacter pylori eradication.
In this report, we aimed to present a case of duodenal MALT lymhoma that was visible in one year and was resistant to Helicobacter pylori eradication.

Case
A 47-year-old female patient was admitted to our clinic with epigastric pain. There was no history of any previous disease. Her physical examination, routine hematology, and biochemistry tests were normal. It was learned that the patient underwent endoscopy 1 years ago. The endoscopy did not reveal any findings except pangastrit.
A gastroduodenoscopy performed again. In gastroduodenoscopy, apical duodenum was observed edematous, fragile and granular; multiple small ulcerated and vegetan lesions were seen. There were no gastric or esophageal lesions. Multiple duodenal and gastric biopsies were taken during endoscopy. Histology of the duodenal lesion was compatible with MALT lymphoma (Figure 1 and Figure 2). The pathology spesiemens show that; duodenal biopsy revealed atypical lymphoid infil-

Introduction
Primary MALT lymphoma represents approximately 8% of the total number of non-Hodgkin lymphoma [1]. GI MALT lymphomas usually occur in the stomach, sometimes the jejunum, the ileum, and rarely the duodenum [2]. The stomach is the most common site of localization. The role of Helicobacter pylori in the pathogenesis of gastric MALT lymphoma is a well known issue [3]. H. pylori eradication is the first line treatment for gastric MALT lymphoma.
Intestinal MALT lymphoma is a very rare neoplasm and there is limited data about clinical and pathological characteristics. In some cases, endoscopic appearance is similar to adenocarcinoma. However, lymphomas Diagnosis of MALT lymphoma of the small intestine was considered, and firstly we decided to Helicobacter pylori eradication. For this treatment we planned; pantoprazol 40 mg 2 × 1, tetrasiclin 500 mg 4 × 1, metronidazol 500 mg 3 × 1 and bizmuth subsalisilat 4 × 1 for 14 days.
Control gastroduodenoscopy 4 week after treatment, no change in lesions was observed. After this treatment the patient subsequently underwent cyclophosphamide, hydroxydaunorubicin, oncovin, prednisolone, and rituximab chemotherapy. The patient is still being followed.

Discussion
Although MALT lymphoma is usually a tumor of interest to the gastrointestinal tract, it can also be seen in organs such as salivary glands, thyroid gland, lung, and skin [4]. Among these sites, MALT lymphoma arising from the gastric mucosa is the most frequently reported, accounting for more than 75% of gastrointestinal tration with centrocyte-like morphology ( Figure 3); immunophenotypic investigation was positive for CD 20(+) and negative for CD3 and CD10 (Figure 4 and Figure 5). In gastric biopsies Helicobacter pylori was positive. In bone marrow biopsy, mild hypercellularity was seen and infiltration was not detected. Her colonoscopy and CT scan was normal.