Demographic, clinical, radiographic, histological, and immunohistochemical features of reported cases of Diffuse Large B Cell Lymphoma in the tonsillar area.

Table 1: Demographic, clinical, radiographic, histological, and immunohistochemical features of reported cases of Diffuse Large B Cell Lymphoma in the tonsillar area.

S.No.	Author Details	Age/Sex	Chief Complaint	Clinical Features	Radiographic Features	Histopathology	Ihc (+/-)	Diagnosis
1.	Rai, et al. 2021	65/M	Swelling left tonsillar fossa past 10 days, sudden in onset, associated with difficulty while swallowing food, and change in voice past 5 days	Unilateral growth with smooth bosselated surface arising from left tonsillar fossa (5 × 8 cm) pushing anterior and posterior tonsillar pillars, inferiorly extending up to left vallecula crossing the midline.	Well-defined globular soft tissue density along left posterior pharyngeal wall extending up to soft palate.	Complete effacement of tonsillar architecture replaced by tumour tissue sheets of monomorphic medium to large round to mildly indented cells with vesicular nuclei and variable number of nucleoli. Atypical mitotic figures and numerous karyorrhectic debris.	CD20, CD45, CD10, and Ki-67(+).	Diffuse large B-cell non-Hodgkin’s type of lymphoma.
2.	Kof, et al. 1996	72/M	Mass in mouth noticed 3 weeks before and continued to enlarge.	No history of fever, night sweats, malaise or weight loss. 5 × 5 cm mass noted on left tonsillar fossa. No palpable cervical nodes.	Mass lesion originating from left tonsillar fossa and protruding into the oropharyngeal passage and nasopharyngeal area.	NA	NA	Non-Hodgkin’s lymphoma of the "intermediate grade" diffuse mixed small and large cell type
3.	Gu, et al. 2013	5/M	Snoring and open mouth opening for 3 years. No fever, night sweats, lymphadenopathy or weight loss.	NA	NA	Large, monomorphic atypical lymphoid cells were diffusely proliferated.	CD20, Bcl-2, Bcl-6 Mum1, CD56(+). CD5, CD7, CD10, EBV PCR (-). Immunoglobulin heavy chain rearrangement showed monoclonality.	Diffuse B-cell lymphoma.
Bc4.	Rajabato, et al. 2021	59/M	Sore throat for one month. Dysphagia, odynophagia and unusual snoring. No history of weight loss, night sweats or prolonged fever.	Unilateral swelling of the right tonsil and lymphadenopathy of the right Mandible.	Solid tumour mass of right palatine tonsil (3.65 × 3.39 × 3.88 cm) and multiple lymph nodes less than 1 cm at submandibular level	Diffuse proliferation of large-sized tumour cells with pleomorphic nuclei, coarse chromatin and scanty eosinophilic cytoplasm.	CD45, CD20, BCL-2, BCL-6, MUM1 (+). CD10, Cyclin-D1(-). Ki67(+).	Diffuse B-cell lymphoma.
5.	Torres, et al. 2020	50/M	Odynophagia for past 1 month followed by left painful cervical swelling.	Left tonsil enlargement with exudate suspicious of a tonsillar abscess, associated with left cervical tender swelling	Mildly enhancing homogenous lesion in left palatine tonsil, and a similar small mass on right tonsil. Bilateral lymphadenopathies in cervical lymph node, mediastinal, pulmonary hilum and axilla.	Features suggestive of non-Hodgkin’s lymphoma.	CD20, CD45, BCL-2 (+). CD30(-).	Diffuse Large B-cell lymphoma.
8.	Ma, et al. 2019	NA	NA	49 cases in the Tonsillar region	NA	NA	MUM1, BCL-2, BCL-6, and C-MYC (+). IRF4 (+).	Diffuse large B- cell lymphoma
9.	Triantafillidou, etal. 2012	NA	NA	4 cases in the Waldeyer ring	NA	NA	CD5, CD10, CD20, CD23, Bcl-2, Bcl-6, MUM1, cyclin D1, Ki67, and Tdt (+).	Diffuse large B- cell lymphoma

*M: Male; NA: Not Applicable; CD: Cluster of Differentiation; Ki: Kiel, Bcl: B-Cell Lymphoma; MUM: Multiple Myeloma oncogene; EBV PCR: Ebstein- Barr Virus Polymerase Chain Reaction; C-MYC: Cellular Myelocytomatosis; IRF: Interferon Regulatory Factor; Tdt: Terminal Deoxynucleotidyl Transferase