Table 1: Wieberdink grading of limb toxicity [7].
| Grade I | No subjective or objective evidence of reaction |
| Grade II | Slight erythema and/or edema |
| Grade III | Considerable erythema and/or edema with some blistering; Slightly disturbed motility |
| Grade IV | Extensive epidermolysis and/or obvious damage to the deep tissue causing definite functional disturbances; threatening or manifest compartment syndrome |
| Grade V | Severe reaction which may necessitate amputation |