Table 1: Wieberdink grading of limb toxicity [7].

Grade I No subjective or objective evidence of reaction
Grade II Slight erythema and/or edema
Grade III Considerable erythema and/or edema with some blistering;
Slightly disturbed motility
Grade IV Extensive epidermolysis and/or obvious damage to the deep tissue causing definite functional disturbances; threatening or manifest compartment syndrome
Grade V Severe reaction which may necessitate amputation