Table 1: Wieberdink grading of limb toxicity .
|Grade I||No subjective or objective evidence of reaction|
|Grade II||Slight erythema and/or edema|
|Grade III||Considerable erythema and/or edema with some blistering;
Slightly disturbed motility
|Grade IV||Extensive epidermolysis and/or obvious damage to the deep tissue causing definite functional disturbances; threatening or manifest compartment syndrome|
|Grade V||Severe reaction which may necessitate amputation|