Table 1:Primary and secondary adrenal insufficiency etiology. AIDS: Acquired Immune Deficiency Syndrome.

Primary Adrenal Insufficiency Secondary Adrenal Insufficiency
Autoimmune adrenalitis (80-90% in developed countries) Pituitary tumors or other tumors of the hypothalamus-pituitary region (adrenal
failure secondary to tumor growth, surgery or radiotherapy performed)
Infectious adrenalitis (Tuberculosis, AIDS, fungic infection, etc) Lymphocytic hypophysitis (alone or as part of a polyglandular autoimmune syndrome)
Bilateral adrenalectomy Glucocorticoid excess intake
Congenital disorders (congenital adrenal hyperplasia due to 21-hydroxylase deficiency,
11p hydroxylase deficiency, 3β deshidrogeanase hydroxysteroid deficiency, or 17α
hydroxylase deficiency)
Pituitary apoplexy/Sheehan Syndrome
Tumor infiltration Pituitary infiltration (Tuberculosis, sarcoidosis, Wegener granulomatosis)
Bilateral adrenal hemorrhage Craneoencephalic traumatism