Table 1: Simplified criteria for diagnosis of autoimmune hepatitis [9].

Variable

ANA or SMA

Cut-off

≥ 1:40

Points

1

ANA or SMA ≥ 1:80 2a
Or anti-LKM-1 ≥ 1:40
Or SLA Positive

IgG

 

> upper limit of normal

> 1.10 times upper limit of normal

1

2

Liver histology

 

Compatible with AIH

Typical of AIH

1

2

Absence of viral hepatitis Yes 2

Score ≥ 6: Probable AIH; ≥ 7: Definite AIH.

ANA: anti-nuclear antibody; SMA: anti-smooth muscle antibody; anti-LKM-1: anti- liver kidney microsomal antibody type 1; SLA: Soluble liver antigen; IgG: Immune- globulin G; AIH: autoimmune hepatitis.

a: Addition of points achieved for all autoantibodies cannot exceed a maximum of 2 points Adapted from [9].