Table 1: Simplified criteria for diagnosis of autoimmune hepatitis [9].
Variable ANA or SMA |
Cut-off ≥ 1:40 |
Points 1 |
ANA or SMA | ≥ 1:80 | 2a |
Or anti-LKM-1 | ≥ 1:40 | |
Or SLA | Positive | |
IgG
|
> upper limit of normal > 1.10 times upper limit of normal |
1 2 |
Liver histology
|
Compatible with AIH Typical of AIH |
1 2 |
Absence of viral hepatitis | Yes | 2 |
Score ≥ 6: Probable AIH; ≥ 7: Definite AIH.
ANA: anti-nuclear antibody; SMA: anti-smooth muscle antibody; anti-LKM-1: anti- liver kidney microsomal antibody type 1; SLA: Soluble liver antigen; IgG: Immune- globulin G; AIH: autoimmune hepatitis.
a: Addition of points achieved for all autoantibodies cannot exceed a maximum of 2 points Adapted from [9].