Table 2: Reasons for study exclusion.

Exclusion group

Reason for exclusion

# Of References

Duplicate references (774)

Duplicate studies

774

Irrelevant exposure (260)

Non-quinolone related studies

260

Unavailable full-text (6)

Reference could not be retrieved

6

Irrelevant population (41)

Current or prior liver impairment

41

Non-original studies (971)

Non-original studies

971

Irrelevant study design (1,190)

Quinolone combined with other drugs

284

Cross-over trial

194

No results available

167

Trial with multiple arms

149

Quinolone in a topical formulation

126

Observational study

106

Trial with a single arm

96

Quinolones on multiple arms

68

Irrelevant publication type (179)

Review article

89

Case report/case series

73

Letter/commentary

7

Not a clinical trial

6

Report

3

Conference abstract

1

Eligible trials

Eligible clinical trials with no reporting on acute liver failure

137