Mean QTc during four years for patients in MMT with five ECGs available (n = 36).

Table 3: Mean QTc during four years for patients in MMT with five ECGs available (n = 36).

	QTc interval (ms)	QTc prolongated^a	QTc dangerously prolongated^a	No methadone use	F-value	p-value
T0	425.3 ± 21.5	3 (8.3)	0	2 (5.9) [2]	1.165	0.328
T1	427.6 ± 27.1	4 (11.1)	1 (2.8)	0
T2	433.5 ± 22.1	7 (19.4)	0	0
T3	429.7 ± 21.6	6 (16.7)	0	0
T4	431.8 ± 24.7	2 (5.6)	1 (2.8)	0

Numbers are mean ± standard deviation or number (%) [missing data]; aThe QTc interval was divided into three categories; normal (< 450 ms for males and < 460 ms for females), prolonged (≥ 450 -< 500 ms for males and ≥ 460 -< 500 ms for females), and dangerously prolonged (≥ 500 ms for males and females). F-value: Greenhouse-Geisser test for within subjects effects T0-T4.