Table 5: The toxicity profiles of the lead compounds.
Compounds |
LD50 (mg/kg) |
TC |
CG |
HT |
MG |
CT |
IT |
PA |
C1 |
900 |
4 |
- |
- |
- |
- |
- |
100 |
C2 |
900 |
4 |
- |
- |
- |
- |
- |
100 |
C3 |
1320 |
4 |
- |
- |
- |
- |
+ |
69.26 |
C4 |
2000 |
4 |
- |
- |
- |
- |
- |
68.07 |
C5 |
2500 |
5 |
- |
- |
- |
- |
+ |
70.97 |
C6 |
23000 |
6 |
- |
- |
- |
- |
- |
67.38 |
C7 |
150 |
3 |
- |
- |
- |
- |
+ |
69.26 |
C8 |
6060 |
6 |
- |
- |
- |
- |
- |
67.38 |
C9 |
2000 |
4 |
- |
- |
- |
- |
- |
68.07 |
C10 |
2000 |
4 |
- |
- |
- |
- |
- |
70.97 |
C11 |
150 |
3 |
- |
- |
- |
- |
+ |
69.26 |
C1 = Myristic Acid, C2 = Palmitic Acid, C3 = Xanthinin, C4 = 2,3-Dehydro-4-oxo-beta-ionol, C5 = Coniferyl alcohol, C6 = alpha-D-glucopyranoside, C7 = Ambrosiol, C8 = 2,3,5,5,8a-pentamethyl-6,7,8,8a-tetrahydro-5H-chromen-8-ol, C9 = (7E)-2,6,6-Trimethyl-3-methylene-7-(3-oxobutylidene) oxepanyl acetate, C10 = (8S,14)-cedran-diol, C11 = 3-oxo-10(14)-epoxyguai-11(13)-en-6,12-olide.
Key: TC: Toxicity class; CG: Carcinogenicity; HT: Hepatotoxicity; MG: Mutagenicity; CT: Cytotoxicity; IT: Immunotoxicity; PA: Prediction accuracy (%)